AXOTOMY

作品数：29被引量：60H指数：4
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相关领域：医药卫生生物学更多>>
相关期刊：《Science China(Life Sciences)》《Neural Regeneration Research》《Journal of Behavioral and Brain Science》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains
《Neural Regeneration Research》2025年第9期2667-2681,共15页Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak Dale R.Sengelaub George D.Bittner 
supported by DOD AFIRMⅢW81XWH-20-2-0029 subcontract,UT POC19-1774-13;Neuraptive Therapeutics Inc.26-7724-56;NIH R01-NS128086 grants;Lone Star Paralysis gift(to GDB)。
Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Walle...
关键词：autophagia AXOTOMY collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration 
Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord被引量：1
《Neural Regeneration Research》2025年第7期2095-2107,共13页Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub 
supported by the Department of Defense AFIRMⅢW81XWH-20-2-0029 grant subcontract;Lone Star Paralysis gift,UT POC19-1774-13 grant;Neuraptive Therapeutics Inc.26-7724-56 grant;National Institutes of Health R01-NS128086(all to GDB)。
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene g...
关键词：AXOTOMY dorsal horn peripheral nerve injury PLASTICITY polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase 
Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion
《Neural Regeneration Research》2025年第4期1192-1206,共15页Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner 
supported by grants from the Lone Star Paralysis Foundation,NIH R01NS081063;Department of Defense award W81XWH-19-2-0054 to GDB;supported by University of Wyoming Startup funds,Department of Defense grant W81XWH-17-1-0402;the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH)award number 5P20GM121310-02;the National Institute of General Medical Sciences of the NIH under award number P20GM103432 to JSB。
Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration.Furthermore,such peripher...
关键词：allograft rejection AXOTOMY macrophage MYELIN nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration 
miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells被引量：1
《Neural Regeneration Research》2025年第1期277-290,共14页Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi 
supported by the National Natural Science Foundation of China,No.31870977(to HYS);the National Key Technologies Research and Development Program of China,No.2017YFA0104700(to FD);2022 Jiangsu Funding Program for Excellent Postdoctoral Talent(to MC);Priority Academic Program Development of Jiangsu Higher Education Institutions[PAPD];the Major Project of Basic Science(Natural Science)Research in Higher Education Institutions of Jiangsu Province,No.22KJA180001(to QRH)。
Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve repair.Cell-based therapy can enhance peripheral nerve rep...
关键词：AXOTOMY cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors 
Molecular mechanisms of neurite regeneration and repair:insights from C.elegans and Drosophila
《Cell Regeneration》2023年第1期284-294,共11页Xiaofan Liu Yuqing Zhao Wei Zou 
supported by grants from the National Science Foundation of China(31970919)to W.Z.
The difficulties of injured and degenerated neurons to regenerate neurites and regain functions are more significant than in other body tissues,making neurodegenerative and related diseases hard to cure.Uncovering the...
关键词：Neurite regeneration Neurite repair Caenorhabditis elegans Drosophila melanogaster Genetic manipulation Live imaging Subcellular structures AXOTOMY Dendrotomy DLK-1 
DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish被引量：1
《Neural Regeneration Research》2023年第3期577-581,共5页Guo-Jian Shao Xin-Liang Wang Mei-Li Wei Da-Long Ren Bing Hu 
granted by the National Natural Science Foundation of China,No.82071357;Ministry of Science and Technology of China,No.2019YFA0405600(both to BH).
Axon regeneration of central neurons is a complex process that is tightly regulated by multiple extrinsic and intrinsic factors.The expression levels of distinct genes are changed after central neural system(CNS)injur...
关键词：axon regeneration central nervous system CRISPR/Cas9 DUSP2 JNK Mauthner cell single-cell electroporation spinal cord injury two-photon axotomy ZEBRAFISH 
The proteome of distal nerves: implication in delayed repair and poor functional recovery
《Neural Regeneration Research》2022年第9期1998-2006,共9页Song Guo Raymond M.Moore M.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang 
supported by Helene Houle Career Development Award in Neurologic Surgery Research and Fund for Mayo Clinic Center for Regenerative Medicine Program Director,Neuroregenerative Medicine,Mayo Clinic College of Medicine and Science.SG was supported by the Chinese Scholarship Council.
Chronic denervation is one of the key factors that affect nerve regeneration.Chronic axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for regeneration...
关键词：chronic axotomy chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation PROTEOME sciatic nerve sciatic nerve transection 
Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system被引量：2
《Neural Regeneration Research》2021年第11期2125-2131,共7页Fernando Lucas-Ruiz Caridad Galindo-Romero Virginia Albaladejo-García Manuel Vidal-Sanz Marta Agudo-Barriuso 
supported by the Spanish Ministry of Economy and Competitiveness,Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”(PI19/00071[to MAB],PID2019-106498GB-I00[to MVS],RD16/0008/0026[to MVS]and RD16/0008/0016[to MVS]);the Fundación Séneca,Agencia de Ciencia y Tecnología Región de Murcia(19881/GERM/15)(to MVS).
The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments.During the last decade is becoming clear that unilateral lesions in ...
关键词：bilateral effect brain glaucoma inflammation mirror effect optic nerve axotomy optic nerve crush retina spinal cord 
Methylene blue enhances polyethylene glycol-fusion repair of completely severed rat sciatic nerves被引量：3
《Neural Regeneration Research》2021年第10期2056-2063,共8页Cameron L.Ghergherehchi Jaimie T.Shores Joseph Alderete Erik K.Weitzel George D.Bittner 
This work was supported by a grant from Department of Defense Peer Reviewed Orthopaedic Research Program award(grant No.OR180077 W81XWH-19-2-0054;to GDB)。
Complete transection of peripheral mixed nerves immediately produces loss of sensory perception,muscle contractions and voluntary behavior mediated by the severed distal axons.In contrast to natural regeneration(~1 mm...
关键词：AXOTOMY methylene blue nerve repair NEURORRHAPHY peripheral nerve injury polyethylene glycol fusion sciatic nerve 
Exercise promotes recovery after motoneuron injury via hormonal mechanisms被引量：1
《Neural Regeneration Research》2020年第8期1373-1376,共4页Cory Chew Dale R.Sengelaub 
supported by NIH-NINDS NS047264 to DRS
Injuries to spinal motoneurons manifest in a variety of forms,including damage to peripheral axons,neurodegenerative disease,or direct insult centrally.Such injuries produce a variety of negative structural and functi...
关键词：axon regeneration AXOTOMY dendritic morphology EXERCISE HORMONES neuroprotection NEUROTROPHINS 
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