In healthy intervertebral discs(IVDs),nerves and blood vessels are present only in the outer annulus fibrosus,while in degenerative IVDs,a large amount of nerve and blood vessel tissue grows inward.Evidence supports t...
Laboratory Animal Foundation Program of Military,Grant/Award Number:SYDW[2018]01;Promotion Plan of the Air Force Medical University,Grant/Award Number:2020SWAQ11;Shaanxi Province Innovation Capability Support Plan,Grant/Award Number:2021PT-037。
Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and test...
supported by the Intramural Research Program National Institute on Aginq,NIH。
Toxic aggregated amyloid-βaccumulation is a key pathogenic event in Alzheimer’s disease.Treatment approaches have focused on the suppression,deferral,or dispersion of amyloid-βfibers and plaques.Gene therapy has ev...
Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline.This process represents the major risk factor for aging-related diseases such as Alz...
Aging is a global phenomenon and a complex biological process of all living beings that introduces various changes.During this physiological process,the brain is the most affected organ due to changes in its structura...
The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses,modify the resp...
There is an increasing recognition of the strong links between the gut microbiome and the brain,and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the cent...
Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells.Recent works have revealed that the dy...
This study was supported by grants from CAMS Innovation Fund for Medical Science(Nos.2017-I2M-1-016 and 2019-I2M-2-006);Natural Science Foundation of Tianjin(No.19JCYBJC26600);China Postdoctoral Science Foundation(Nos.2019M660921 and 2020T130436);Science Foundation for Post Doctorate Research of the Beijing(Nos.2017-ZZ-123 and 2020-ZZ-005);Youth Backbone Project from Chinese Academy of Medical Science Institute of Radiation Medicine(No.2019043).
Background Our goal was to evaluate the association between neonatal blood brain-derived neurotrophic factor(BDNF)level and autism spectrum disorder(ASD)diagnosis later in life.Methods MEDLINE and Web of Science datab...