Neurotrophins and neural stem cells in posttraumatic brain injury repair  

作　　者：Wenwen Guo Ke Liu Yinghua Wang Xu Ge Yifan Ma Jing Qin Caiqin Zhang Ya Zhao Changhong Shi 

机构地区：[1]Laboratory Animal Center,Fourth Military Medical University,Xi'an,P.R.China [2]Gansu University of Traditional Chinese Medicine,Lanzhou,P.R.China [3]Medical College of Yan'an University,Yan'an,P.R.China

出　　处：《Animal Models and Experimental Medicine》2024年第1期12-23,共12页动物模型与实验医学（英文）

基　　金：Laboratory Animal Foundation Program of Military,Grant/Award Number:SYDW[2018]01;Promotion Plan of the Air Force Medical University,Grant/Award Number:2020SWAQ11;Shaanxi Province Innovation Capability Support Plan,Grant/Award Number:2021PT-037。

摘　　要：Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains elusive.Studies have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory function.These factors are instrumental in alleviating neu-roinflammation and promoting neuroregeneration.In addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular signaling.Notably,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI.In this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with NSCs.This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.

关 键 词：mutual effect neural stem cells neurological function NEUROTROPHINS traumatic brain injury 

分 类 号：R-332[医药卫生]