医药卫生

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相关作者：王伟胡大一李静张伟李莉更多>>
相关机构：复旦大学华中科技大学第二军医大学山东大学更多>>
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发文基金：国家自然科学基金国家重点基础研究发展计划国家科技重大专项广东省自然科学基金更多>>
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Neuromodulation technologies improve functional recovery after brain injury:From bench to bedside
《Neural Regeneration Research》2026年第2期506-520,共15页Mei Liu Yijing Meng Siguang Ouyang Meng’ai Zhai Likun Yang Yang Yang Yuhai Wang 
supported by the National Natural Science Foundation of China,No.82371399(to YY);the Natural Science Foundation of Jiangsu Province,No.BK20221206(to YY);the Young Elite Scientists Sponsorship Program of Jiangsu Province,No.TJ-2022-028(to YY);the Scientific Research Program of Wuxi Health Commission,No.Z202302(to LY)。
Spontaneous recovery frequently proves maladaptive or insufficient because the plasticity of the injured adult mammalian central nervous system is limited.This limited plasticity serves as a primary barrier to functio...
关键词：functional recovery invasive electrical stimulation NEUROMODULATION noninvasive electrical stimulation stroke transcranial magnetic stimulation transcranial photobiomodulation transcranial ultrasound stimulation traumatic brain injury 
Optogenetic approaches for neural tissue regeneration:A review of basic optogenetic principles and target cells for therapy
《Neural Regeneration Research》2026年第2期521-533,共13页Davletshin Eldar Sufianov Albert Ageeva Tatyana Sufianova Galina Rizvanov Albert Mukhamedshina Yana 
supported by a grant from the Russian Science Foundation,No.23-75-10041(to MY)。
Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins known as opsins.This review article discusses the fundamental principles of opt...
关键词：adeno-associated virus ASTROCYTES bioluminescent optogenetics channelrhodopsins halorhodopsins MICROGLIA neural stem cells NEURONS OLIGODENDROCYTE OPTOGENETICS 
Measuring glymphatic function:Assessing the toolkit
《Neural Regeneration Research》2026年第2期534-541,共8页Koushikk Ayyappan Lucas Unger Philip Kitchen Roslyn MBill Mootaz MSalman 
supported by the European Union Horizon 2020 Research and Innovation Programme(Marie Skłodowska-Curie grant agreement No 847419);supported by the Biotechnology and Biological Sciences Research Council via a Discovery Fellowship(BB/W00934X/1);the Aston University RKE Pump Priming Programme;funded by UKRI’s Research England as part of their Expanding Excellence in England(E3)fund;supported by a UKRI Frontier Research Grant EP/Y023684/1(following assessment as an ERC Advanced grant,FORTIFY,ERC-2022-ADG-101096882 under the UK Government Guarantee scheme)and acknowledged a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).MMS was supported by a Medical Research Council Career Development Award(MR/W027119/1);acknowledged support from the BHF Centre of Research Excellence,University of Oxford(grant code:RE/24/130024);a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).
Glymphatic flow has been proposed to clear brain waste while we sleep.Cerebrospinal fluid moves from periarterial to perivenous spaces through the parenchyma,with subsequent cerebrospinal fluid drainage to dural lymph...
关键词：AQUAPORIN-4 cerebrospinal fluid EFFLUX glymphatics imaging INFLUX methods microfluidics PARENCHYMA periarterial perivenous TRACER 
Innovative gene delivery systems for retinal disease therapy
《Neural Regeneration Research》2026年第2期542-552,共11页Hongguang Wu Ling Dong Shibo Jin Yongwang Zhao Lili Zhu 
Hongguang Wu,Both authors contributed equally to this work and share first authorship;Ling Dong,Both authors contributed equally to this work and share first authorship;。
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can...
关键词：adeno-associated viruses delivery systems gene delivery gene therapy LENTIVIRUS nanoparticle delivery non-viral delivery retinal disease RETINA small molecular delivery 
Sesquiterpene lactones as potential drugs treating nerve injury
《Neural Regeneration Research》2026年第2期671-672,共2页Philipp Gobrecht Marco Leibinger Dietmar Fischer 
supported by The German Research Foundation.
Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,...
关键词：traumatic axonal lesions peripheral nervous system s axonal regrowththis permanent impairements nerve injury peripheral nerves disrupt neuronal connections sesquiterpene lactones 
Stress signaling caused by mitochondrial import malfunction can be terminated by SIFI:Importance of stress response silencing
《Neural Regeneration Research》2026年第2期673-674,共2页Grace Hohman Michael Shahid Mohamed A.Eldeeb 
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...
关键词：activation stress pathways neurodegenerative disorders protein aggregatesmitochondrial import stress stress signaling protein aggregates goiran protein aggregates protein aggr neurodegenerative diseasesincluding 
p21 as an essential regulator of neurogenic homeostasis in neuropathological conditions
《Neural Regeneration Research》2026年第2期675-676,共2页Valentina Mastrorilli Stefano Farioli-Vecchioli 
supported by PRIN/MUR funding(to VM).
Adult neurogenesis is a highly dynamic process that leads to the production of new neurons from a population of quiescent neural stem cells(NSCs).In response to specific endogenous and/or external stimuli,NSCs enter a...
关键词：adult neurogenesis quiescent neural stem cells nscs precise molecular pathways mitotic activationinitiating cellular changes neurogenic homeostasis neural progenitorswhich production new neurons 
Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries
《Neural Regeneration Research》2026年第2期677-678,共2页Diana Acosta Cankun Wang Qin Ma Hongjun Fu 
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...
关键词：sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq 
Mitochondria-derived vesicles:New players in the game of neurodegeneration
《Neural Regeneration Research》2026年第2期679-680,共2页Laura Palumbo Domenico Nuzzo Antonella Girgenti Pasquale Picone 
supported by project Emerging Infectious Diseases One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases,INF-ACT,Spoke 1 and Spoke 5,Project number PE00000007,CUP B53C20040570005(to PP and DN).
Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derive...
关键词：extracellular vesicles cell cell communication vesicular traffickingmitochondrial derived NEURODEGENERATION mitochondria derived vesicles vesicular trafficking extracellular vesicle ev first 
Amyloid-βis NOT only the most promising target for Alzheimer’s disease
《Neural Regeneration Research》2026年第2期681-682,共2页Beka Solomon Milana Voronov-Goldman 
Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...
关键词：amyloid precursor protein app initially intracellular peptides amyloid cascade hypothesis amyloid cascade hypothesis highlights AMYLOID tau Alzheimers disease SECRETASE 
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