SECRETASE

作品数：20被引量：76H指数：5
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相关领域：医药卫生更多>>
相关作者：崔进路睿王以政王军锋裴刚更多>>
相关机构：同济大学ApoPharma公司中国科学院上海生命科学研究院伊利诺伊大学更多>>
相关期刊：《ChemPhysMater》《Medicinal Plant》《Frontiers in Biology》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金更多>>
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Effects of Honeysuckle Chlorogenic Acid on Secretory Enzymes,Lipoxygenase A4,and Biochemical Indicators inModel Mice with Aluminum Induced Alzheimer's Disease
《Medicinal Plant》2024年第5期35-38,43,共5页Jialing HUANG Cuijuan HUANG Xiaomian TANG Weiming ZHOU Hanchao FENG Cuiping WEI Oufei HUANG Haipeng ZHANG Song NONG Shuqiu ZHANG Fuyu PAN 
Supported by Baise Science Research and Technology Development Plan Project(20232022);Cuangxi College Students’Innovation and Entrepreneurship Training Program(Recommend National Level2022210599040S).
[Objectives]To explore the effects of chlorogenic acid from honeysuckle on the secretion enzymes,lipoxygenase A4(LXA4),and blood biochemical indicators in mice with aluminum induced Alzheimer's disease(AD).[Methods]Ch...
关键词：Alzheimer's disease Chlorogenic acid SECRETASE Lipoxygenase A4 
Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations
《ChemPhysMater》2024年第3期303-313,共11页Ahmad Sajjad Jinfei Mei Chuanbo Wang Hongqi Ai 
supported by Shandong Provincial Natural Science Foundation of China(ZR2022MB073).
Gamma secretase(GS)is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid membranes.The enzyme is responsible for amyloid-β propagation,one of the well-known causes of Alzheime...
关键词：Five lipids Gamma secretase PRESENILIN NICASTRIN Effect of lipid on GS 
Icariside Ⅱ inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway被引量：11
《Acta Pharmacologica Sinica》2020年第2期154-162,共9页Yong Zheng Yan Deng Jian-mei Gao Chun Lv Ling-hu Lang Jing-shan Shi Chang-yin Yu Qi-hai Gong 
the National Natural Science Foundation of China(Grant No.81560585);the Program for Excellent Young Talents of Zunyi Medical University(Grant No.15zy-002);the Zunyi Medical University Masters Startup Fund(F-758);The"Hundred"Level of High-Level Innovative Talents in Guizhou Province(Grant No.QKHRCPT 20165684);the Education Department of Guizhou Province of China(Grant No.GNYL(2017)006,YLXKJS-YS-06);Shijingshan's Tutor Studio of Pharmacology[GZS-2016(07)];the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT_17R113);the 2011 Collaborative Innovation Center of Guizhou Traditional Chinese Medicine and Ethnic Medicine(No.Qianjiaokeyanfa[2012]311).
β-amyloid(Aβ)is one of the inducing factors of astrocytes activation and neuroinflammation,and it is also a crucial factor for the development of Alzheimer’s disease(AD).Icariside II(ICS II)is an active component i...
关键词：icarisideⅡ DEXAMETHASONE ASTROCYTES nuclear factor-kappa B beta secretase 1 Β-AMYLOID neuroinflammation Alzheimer’s disease 
Notoginseng Saponin Rg1 Prevents Cognitive Impairment through Modulating APP Processing in Aβ1-42-injected Rats被引量：13
《Current Medical Science》2019年第2期196-203,共8页Shang-zhi LIU Wei CHENG Jia-wei SHAO Yun-fan GU Yi-yi ZHU Qi-jing DONG Si-yu BAI Ping WANG Li LIN 
the National Natural Science Foundation of China(No.81673856,and No.81573865);Postdoctoral Science Foundation of China(No.2016M592319,and No.2017T100542);National Innovation and Entrepreneurship Training Program for College Students(No.201810507019).
With the intensification of the aging process of the world,Alzheimer's disease(AD),which is the main type of senile dementia,has become a primary problem in the present society.Lots of strategies have been used to pre...
关键词：notoginseng SAPONIN RG1 Alzheimer's disease spatial learning and memory deficits Β-AMYLOID peptide SECRETASE degrading cnzyme 
α-secretase ADAM IO physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis被引量：3
《Journal of Molecular Cell Biology》2018年第5期411-422,共12页Xin Wang Congcong Wang Gang Pei 
α-secretase and β-secretase are known to compete for amyloid precursor protein （APP） processing and thus play a vital role in Alzheimer＇s disease pathogenesis. A disintegrin and metaUoproteinase 10 （ADAM10） and...
关键词：SECRETASE Alzheimer＇s disease ADAM10 BACE1 interact APP CHL1 
Beta secretase activity in peripheral nerve regeneration被引量：4
《Neural Regeneration Research》2017年第10期1565-1574,共10页Carolyn Tallon Mohamed H.Farah 
supported by the Muscular Dystrophy Association and R01NS079339 from the National Institutes of Neurological Disease and Stroke of the National Institutes of Health
While the peripheral nervous system has the capacity to regenerate following a nerve injury,it is often at a slow rate and results in unsatisfactory recovery,leaving patients with reduced function.Many regeneration as...
关键词：peripheral nerve axonal regeneration beta-site amyloid precursor protein-cleaving enzyme 1 
Role of BACE1 in Alzheimer’s synaptic function被引量：2
《Translational Neurodegeneration》2017年第1期217-224,共8页Brati Das Riqiang Yan 
R Yan is supported by grants(MH103942,NS074256 and AG046929)from the National Institutes of Health.
Alzheimer’s disease(AD)is the most common age-dependent disease of dementia,and there is currently no cure available.This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary tangles.Alt...
关键词：Amyloid deposition β-amyloid peptide BACE1 SECRETASE BACE1 substrates Synaptic functions 
Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors
《Chinese Chemical Letters》2016年第10期1626-1629,共4页Jia-Kuo Liu Wei Gu Xiao-Rui Cheng Jun-Ping Cheng Ai-Hua Nie Wen-Xia Zhou 
supported by grants from the National Natural Science Foundation of China(No.81172924);Beijing Municipal Natural Science Foundation(No.7112106)
By taking compound 1 as a lead, a series of 5-cyclopropyl substituted cyclic acylguanidine compounds were designed and synthesized as BACE1 inhibitors, compound 4d exhibited 84-fold improved inhibition efficiency than...
关键词：Alzheimer＇s diseaseBACE inhibitor SecretaseDrug discoveryCyclic acylguanidine 
Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs被引量：8
《Translational Neurodegeneration》2016年第1期107-117,共11页Riqiang Yan 
R Yan is supported by the grant(AG025493,MH103942,NS074256 and AG046929)from the National Institutes of Health.
Alzheimer’s disease(AD)is the most common age-dependent neurodegenerative disease which impairs cognitive function and gradually causes patients to be unable to lead normal daily lives.While the etiology of AD remain...
关键词：Alzheimer’s disease Amyloid plaques Amyloid precursor protein SECRETASE BACE1 Aspartyl protease Drug discovery Clinical trials Amyloid deposition β-amyloid peptide Fragment based drug discovery Verubecestat 
Cutting in on a secretase pas de deux
《Cell Research》2015年第10期1091-1092,共2页Michael SWolfe 
Two proteolytic enzymes, β- and γ-secretases, work together to pro- duce the amyloid β-peptide of AI- zheimer＇s disease. New evidence suggests that these proteases directly interact and compounds that dis- rupt th...
关键词：分泌酶 蛋白水解酶 切割 相互作用 化合物 蛋白酶 粉样 
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