supported by National Natural Science Foundation of China(32000252);Natural Science Foundation of Heilongjiang Province of China(YQ2020C014,ZD2019C002);National Key Research and Development Program of China(2017YFC1601901)。
Some research have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus(T2DM)than a single intervention.However,there are still relatively few relevant repo...
supported by the National Natural Science Foundation of China(No.81973192)。
Objective:Paridis Rhizoma(Chonglou in Chinese),a traditional Chinese herbal medicine,has been shown have strong anti-tumor effects.Paris saponinⅦ(PSⅦ),an active constituent isolated from Paridis Rhizoma,was demonstr...
supported by grants from the National Natural Science Foundation of China(#82071013 and#82371118);Joint Fund of Shandong Province(#ZR2021LSW028);the National Natural Science Foundation of Shandong Province(#ZR2023MH106 and#ZR2023MH364);Taishan Scholar Foundation of Shandong Province(#tsqn201812134)。
Allergic rhinitis(AR)has emerged as a global concern,particularly due to the recent rise in disease incidence.There is an urgent need for safer,more effective,and shorter-term targeted immunotherapy approaches.Our pre...
supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);the Applied Basic Research Projects of Yunnan Province(No.202301AY070001-163 to L.Y.);the Scientific Research Fund of Education Department of Yunnan province(Nos.2023Y0793 and 2024Y206 to Z.D.,Y.J.).
With the increasing global population and aging demographic,the incidence of stroke is rising.Among these,ischemic stroke(IS),also known as cerebral ischemia,constitutes over 80%of all stroke cases.This condition is c...
supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).
Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various...
National Natural Science Foundation of China,a New Anti-cancer Plant drug,SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae),against Invasion and Metastasis of Non-small Cell Lung Cancer and Reversing Tyrosine Kinase Inhibitors Resistance basing on Human Growth Factor/c-Mesenchymal to Epithelial Transition Factor Pathway and its Molecular Mechanism of Regulating Epithelial-Mesenchymal Transition(No.8164062);the Natural Science Foundation of Guangxi Province,Study on the Antihepatic Fibrosis Mechanism of Saponins from Shuitianqi(Rhizoma Schizocapasae Plantagineae)based on Transforming Growth Factor-β/Smad Signaling Pathway(No.2019GXNSFAA245075)。
OBJECTIVE:To examine the influence of SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae)(SSPHⅠ)on hepatocellular carcinoma(HCC)metastasis,and to elucidate the underlying mechanism.METHODS:The intrahepatic m...
funded by the National Natural Science Foundation of China(Grant Nos.:82374076,and 82174354);National Key R&D Program of China(Grant No.:2023YFC3504100);Natural Science Foundation of Beijing(Grant No.:7244493);NSFC Cultivating Project of Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(Grant No.:ZXKT23003);Young Elite Cultivating Project of Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(Grant No.:ZZ17-YQ-023);Start-up Fund for New Scientific Researchers of China Academy of Chinese Medical Sciences(Grant No.:ZZ16-XRZ071).
Due to the multitudinous structural types of glycosylated components,accurate identification of glycosylation modifications and secondary metabolite structures in herbs remains a challenge for natural drug analysis an...
supported by grants from Major Special Projects of the Ministry of Science and Technology(No.2021yfd1000202;2021YFD1601003);the Key R&D program of Yunnan Province(No.202103AC100003);National Natural Science Foundation of China(No.31860075).
Objective: Paris polyphylla var. yunnanensis, one of the important medicinal plant resources in Yunnan,China, usually takes 6–8 years to be harvested. Therefore, it is urgent to find a method that can not only shorte...
Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and less...
This study was supported by Beijing Science and Technology Planning Project(Z201100005420005,China).
Saponins are the main triterpenoid ingredients from Panax notoginseng,a well-known Chinese medicine,and are important sources for producing drugs to prevent and treat cerebrovascular and cardiovascular diseases.Howeve...