SAPONIN

作品数:172被引量:703H指数:14
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相关作者:刘忠荣徐凯节吴琼丁立生付宏征更多>>
相关机构:中国科学院中国科学院上海生命科学研究院北京大学中国科学院成都生物研究所更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Polygonatum sibiricum saponin-lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism
《Food Science and Human Wellness》2025年第4期1514-1528,共15页Jiayuan Luo Mingjie Jia Shuang Liang Yangyang Chai Yihong Bao Shilong Jiang 
supported by National Natural Science Foundation of China(32000252);Natural Science Foundation of Heilongjiang Province of China(YQ2020C014,ZD2019C002);National Key Research and Development Program of China(2017YFC1601901)。
Some research have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus(T2DM)than a single intervention.However,there are still relatively few relevant repo...
关键词:PROBIOTICS Polygonatum sibiricum saponin Type 2 diabetes mellitus Gut microbiota METABOLITES 
Paris saponinⅦinduces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling
《Chinese Herbal Medicines》2025年第1期94-107,共14页Xiaoying Qian Yang Liu Wenwen Chen Shuxian Zheng Yunyang Lu Pengcheng Qiu Xisong Ke Haifeng Tang Xue Zhang 
supported by the National Natural Science Foundation of China(No.81973192)。
Objective:Paridis Rhizoma(Chonglou in Chinese),a traditional Chinese herbal medicine,has been shown have strong anti-tumor effects.Paris saponinⅦ(PSⅦ),an active constituent isolated from Paridis Rhizoma,was demonstr...
关键词:CASPASE-3 gasdermin E pancreatic ductal adenocarcinoma paris saponin VII PYROPTOSIS reactive oxygen species 
Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
《Engineered Regeneration》2024年第4期452-467,共16页Wenwen Qi Lei Shi Xinhao Wu Fangyuan Zhu Zhenxiao Teng Xiaochen Gao Xin Bing Na Guo Xue Cao Chengzhilin Li Houyang Hu Fanyu Yuan Yuhan Dong Ming Xia Chengcheng Liu 
supported by grants from the National Natural Science Foundation of China(#82071013 and#82371118);Joint Fund of Shandong Province(#ZR2021LSW028);the National Natural Science Foundation of Shandong Province(#ZR2023MH106 and#ZR2023MH364);Taishan Scholar Foundation of Shandong Province(#tsqn201812134)。
Allergic rhinitis(AR)has emerged as a global concern,particularly due to the recent rise in disease incidence.There is an urgent need for safer,more effective,and shorter-term targeted immunotherapy approaches.Our pre...
关键词:Allergic rhinitis NEUTROPHILS Paris saponins II Metabolomics ALANINE 
Exploring the mechanism of Panax notoginseng saponin in inhibiting the inflammatory response of microglia in cerebral ischemia based on network pharmacology
《Acta Biochimica et Biophysica Sinica》2024年第10期1566-1570,共5页Zhaoda Duan Wenji Jia Jianxiang Wang Dongyao Xu Yujia Yang Zhi Qi Li Yang Chunyun Wu 
supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);the Applied Basic Research Projects of Yunnan Province(No.202301AY070001-163 to L.Y.);the Scientific Research Fund of Education Department of Yunnan province(Nos.2023Y0793 and 2024Y206 to Z.D.,Y.J.).
With the increasing global population and aging demographic,the incidence of stroke is rising.Among these,ischemic stroke(IS),also known as cerebral ischemia,constitutes over 80%of all stroke cases.This condition is c...
关键词:ISCHEMIA CEREBRAL INHIBITING 
The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications
《Acta Pharmaceutica Sinica B》2024年第8期3385-3415,共31页Zichen Luo Wei Zhou Tong Xie Weichen Xu Chen Shi Zihan Xiao Yu Si Yan Ma Qingling Ren Liuqing Di Jinjun Shan 
supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).
Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various...
关键词:Bile acid TRITERPENOID PHYTOSTEROL SAPONIN Gut microbes CHOLESTASIS Metabolic disorders Rheumatoid arthritis 
Saponin Ⅰ from Shuitianqi(Rhizoma Schizocapasae Plantagineae) inhibits metastasis by negatively regulating the transforming growth factor-β1/Smad7 network and epithelial-mesenchymal transition in the intrahepatic metastasis Bagg's Albino/c mouse model
《Journal of Traditional Chinese Medicine》2024年第4期642-651,共10页LYU Meixian ZHOU Huan ZHI Limin ZHOU Jinling GAN Rizhi QIN Yanping HE Nengting ZUO Qiqi LI Hao DONG Min LIANG Gang 
National Natural Science Foundation of China,a New Anti-cancer Plant drug,SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae),against Invasion and Metastasis of Non-small Cell Lung Cancer and Reversing Tyrosine Kinase Inhibitors Resistance basing on Human Growth Factor/c-Mesenchymal to Epithelial Transition Factor Pathway and its Molecular Mechanism of Regulating Epithelial-Mesenchymal Transition(No.8164062);the Natural Science Foundation of Guangxi Province,Study on the Antihepatic Fibrosis Mechanism of Saponins from Shuitianqi(Rhizoma Schizocapasae Plantagineae)based on Transforming Growth Factor-β/Smad Signaling Pathway(No.2019GXNSFAA245075)。
OBJECTIVE:To examine the influence of SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae)(SSPHⅠ)on hepatocellular carcinoma(HCC)metastasis,and to elucidate the underlying mechanism.METHODS:The intrahepatic m...
关键词:carcinoma hepatocellular epithelial-mesenchymal transition transforming growth factor beta1 Smad7 protein Saponin I from Shuitianqi(Rhizoma Schizocapasae Plantagineae) 
Glycomol: A pervasive tool for structure predication of natural saponin products basing on MS data被引量:1
《Journal of Pharmaceutical Analysis》2024年第7期1095-1098,共4页Daotong Zhao Chunguo Wang Hanyun Qu Qinling Rao Bingqing Shen Yinan Jiang Jiayu Gong Yumiao Wang Di Geng Rui Hong Tao Lu Qing Ni Xinqi Deng 
funded by the National Natural Science Foundation of China(Grant Nos.:82374076,and 82174354);National Key R&D Program of China(Grant No.:2023YFC3504100);Natural Science Foundation of Beijing(Grant No.:7244493);NSFC Cultivating Project of Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(Grant No.:ZXKT23003);Young Elite Cultivating Project of Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(Grant No.:ZZ17-YQ-023);Start-up Fund for New Scientific Researchers of China Academy of Chinese Medical Sciences(Grant No.:ZZ16-XRZ071).
Due to the multitudinous structural types of glycosylated components,accurate identification of glycosylation modifications and secondary metabolite structures in herbs remains a challenge for natural drug analysis an...
关键词:STRUCTURE AUXILIARY SAPONINS 
Arbuscular mycorrhiza and plant growth promoting endophytes facilitates accumulation of saponin under moderate drought stress被引量:1
《Chinese Herbal Medicines》2024年第2期214-226,共13页Shubiao Qian Qing Zhang Sha Li Rui Shi Xiahong He Shuhui Zi Tao Liu 
supported by grants from Major Special Projects of the Ministry of Science and Technology(No.2021yfd1000202;2021YFD1601003);the Key R&D program of Yunnan Province(No.202103AC100003);National Natural Science Foundation of China(No.31860075).
Objective: Paris polyphylla var. yunnanensis, one of the important medicinal plant resources in Yunnan,China, usually takes 6–8 years to be harvested. Therefore, it is urgent to find a method that can not only shorte...
关键词:arbuscular mycorrhizal fungi gene expression Paris polyphylla Smith var.yunnanensis (Franch.)Hand.-Mazz plant growth-promoting endophytes steroidal saponin 
Protectivity of Freeze Dried Inactivated Rift Valley Fever Vaccine
《Open Journal of Veterinary Medicine》2024年第2期21-37,共17页Diana M. Abulmagd Mohamed Hassan Atwa Noha Ezz Aldin Marwa Yehia Hammad Taradi Abdel Fattah Said 
Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and less...
关键词:Rift Valley Fever SAPONIN Cabopol Binary Ethylenemine Serum Neutralization Test 
PnMYB4 negatively modulates saponin biosynthesis in Panax notoginseng through interplay with PnMYB1被引量:1
《Horticulture Research》2023年第8期203-215,共13页Jinhui Man Yue Shi Yuying Huang Xiaoqin Zhang Xin Wang Shanhu Liu Gaojie He Kelu An Dongran Han Xiaohui Wang Shengli Wei 
This study was supported by Beijing Science and Technology Planning Project(Z201100005420005,China).
Saponins are the main triterpenoid ingredients from Panax notoginseng,a well-known Chinese medicine,and are important sources for producing drugs to prevent and treat cerebrovascular and cardiovascular diseases.Howeve...
关键词:COMPLEX ACTIVATION SAPONIN 
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