TRITERPENOID

作品数：138被引量：312H指数：9
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相关领域：医药卫生理学更多>>
相关作者：屠鹏飞洪鑫左国营郝小江沈月毛更多>>
相关机构：北京大学中国科学院中国医学科学院北京协和医学院中国科学院成都生物研究所更多>>
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New Triterpenoid Isolated from the Roots of Gouania longipetala Hemsl
《Open Journal of Applied Sciences》2024年第11期3069-3076,共8页Anderson Claver Kimou Kouamé Jean-Michel Koffi Seri Chardin Seri Zachée Louis Evariste Akissi Kurouindé Viviane Nemlin Akoua Philomène Yao-Kouassi Laurence Voutquenne-Nazabadioko 
Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence...
关键词：Gouania longipetala RHAMNACEAE Lupane-Type Triterpenoids 
Cyclocarysaponins A–J,dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus
《Chinese Journal of Natural Medicines》2024年第10期955-964,共10页XI Huiting YUAN Mingming XIE Jianhua WANG Yuanxing 
supported by the National Natural Science Foundation of China(Nos.31960090 and 32160562);the State Key Laboratory of Food Science and Resources,Nanchang University(No.SKLF-ZZB-202129)。
Ten previously undescribed dammarane-type triterpenoid glycosides,cyclocarysaponins A–J(1–10),were isolated from the leaves of Cyclocarya paliurus(Batal.)Iljinskaja.The structures of these compounds were characteriz...
关键词：Cyclocarya paliurus JUGLANDACEAE Triterpenoid glycosides Cyclocarysaponin Cytotoxic activities 
The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications
《Acta Pharmaceutica Sinica B》2024年第8期3385-3415,共31页Zichen Luo Wei Zhou Tong Xie Weichen Xu Chen Shi Zihan Xiao Yu Si Yan Ma Qingling Ren Liuqing Di Jinjun Shan 
supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).
Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various...
关键词：Bile acid TRITERPENOID PHYTOSTEROL SAPONIN Gut microbes CHOLESTASIS Metabolic disorders Rheumatoid arthritis 
Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy
《Acta Pharmaceutica Sinica B》2024年第7期3205-3217,共13页Bing-Chen Zhang Chun-Mei Lai Bang-Yue Luo Jing-Wei Shao 
supported by the National Natural Science Foundation of China(No.82172767);the External Cooperation Research Programs of Science and Technology Department Foundation of Fujian Province,China(No.2023I0038).
Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)monotherapy.However,combination therapy with multi-drugs is limited by the d...
关键词：Ursolic acid SELF-ASSEMBLY Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy IMMUNOTHERAPY 
Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking被引量：1
《Chinese Chemical Letters》2024年第6期353-357,共5页Jinyan Zhang Fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang Zhenlong Wu Wencai Ye Lei Wang 
supported by the Guangdong Basic and Applied Basic Research Foundation(Nos.2020B1515120066 and 2022A1515010010);the National Natural Science Foundation of China[Nos.82293681(82293680)and 82273822];the Science and Technology Key Project of Guangdong Province(No.2020B1111110004);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036);the Fundamental Research Funds for the Central Universities;the support of K.C.Wong Education Foundation。
The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)strategy.Compound...
关键词：Phloroglucinol-triterpenoid adduct MYRTACEAE Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity 
Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco
《Plant Communications》2024年第6期154-172,共19页Geng Chen Zhaokuan Guo Yanyu Shu Yan Zhao Lei Qiu Shaofeng Duan Yuan Lin Simei He Xiaobo Li Xiaolin Feng Guisheng Xiang Bo Nian Yina Wang Zhiyuan Li Chongkang Yang Yang Shi Yingchun Lu Guanze Liu Shengchao Yang Guanghui Zhang Bing Hao 
supported by the Major Science and Technology Projects in Yunnan Province(2019ZF011-1);the Fundamental Research Project of Yunnan(202101AS070037);the Science and Technology Innovation team of Yunnan(202105AE160011);the Major Science and Technique Programs in Yunnan Province(202102AE090042);the Yunnan Characteristic Plant Extraction Laboratory(2022YKZY001);the First Projects of Science and Technology Plan in the Biomedical field in 2021(202102AA310048);the National Natural Science Foundation of China(grant nos.81960691 and 82160727).
Cucurbitacin IIa is a triterpenoid isolated exclusively from Hemsleya plants and a non-steroidal anti-inflammatory drug that functions as the main ingredient of prescription Hemslecin capsules and tablets in China.Syn...
关键词：cucurbitacin IIa oxidosqualene cyclase OSC 11-carbonyl-20b-hydroxy-Cuol Saccharomyces cerevisiae Nicotiana benthamiana Hemsleya chinensis 
Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells
《Chinese Chemical Letters》2024年第5期287-289,共3页Wenyi Mei Lijuan Xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu Zhenjiang Zhao Honglin Li Yufang Xu Zhuo Chen 
supported in part by the National Key Research and Development Program of China(No.2022YFC3400501);the National Natural Science Foundation of China(Nos.81825020 and 82150208 to H.L.);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project(Nos.21S11907900 and 20S11901000 to Z.Z.);sponsored by the National Program for Special Supports of Eminent Professionals;the National Program for Support of Top-Notch Young Professionals.
Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological activities.To clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were desi...
关键词：Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives AUTOPHAGY APOPTOSIS 
Steroids, Tri- and Meroterpenoids with a Quinone Structure—A Review
《International Journal of Organic Chemistry》2024年第1期32-68,共37页Maryam S. M. Aghaei Thies Thiemann 
Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metab...
关键词：STEROID Secosteroid Meroterpenoid TRITERPENOID QUINONE Anti-Tumour Agent Antibiotic Natural Product 
Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids
《Journal of Pharmaceutical Analysis》2024年第3期295-307,共13页Xiao-Feng Huang Ying Xue Li Yong Tian-Tian Wang Pei Luo Lin-Sen Qing 
Sichuan Science and Technology Program(Grant No.:2022ZYD0026);Biological Resources Program,Chinese Academy of Sciences(Grant No.:KFJ-BRP-008-007);the Macao Science and Technology Development Fund(Grant No.:0028/2019/AGJ).
Triterpenoids widely exist in nature,displaying a variety of pharmacological activities.Determining triterpenoids in different matrices,especially in biological samples holds great significance.High-performance liquid...
关键词：TRITERPENOID HPLC DERIVATIZATION Quantification 
A review of structural modification and biological activities of oleanolic acid被引量：1
《Chinese Journal of Natural Medicines》2024年第1期15-30,共16页YANG Huali DENG Minghui JIA Hongwei ZHANG Kaicheng LIU Yang CHENG Maosheng XIAO Wei 
supported by the Lianyungang Postdoctoral Research Funding Program(No.LYG20210018).
Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Si...
关键词：Oleanolic acid DERIVATIVES Pentacyclic triterpenoid Structural modification Biological activities 
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