The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications  

作　　者：Zichen Luo Wei Zhou Tong Xie Weichen Xu Chen Shi Zihan Xiao Yu Si Yan Ma Qingling Ren Liuqing Di Jinjun Shan 

机构地区：[1]Medical Metabolomics Center,Institute of Pediatrics,Jiangsu Key Laboratory of Children’s Health and Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China [3]Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210001,China [4]National Institute of Biological Sciences,Beijing 102206,China [5]Jiangsu Engineering Research Center for Efficient Delivery System of TCM,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3385-3415,共31页药学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).

摘　　要：Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various transporters.They serve to emulsify dietary lipids and act as signaling molecules,regulating the host’s metabolism and immune homeostasis through specific receptors.Therefore,disruptions in BA metabolism,transport,and signaling are closely associated with cholestasis,metabolic disorders,autoimmune diseases,and others.Botanical triterpenoids and steroids share structural similarities with BAs,and they have been found to modulate BA metabolism,transport,and signaling,potentially exerting pharmacological ortoxicological effects.Here,we have updated the research progress on BA,with a particular emphasis on new-found microbial BAs.Additionally,the latest advancements in targeting BA metabolism and signaling for disease treatment are highlighted.Subsequently,the roles of botanical triterpenoids in BA metabolism,transport,and signaling are examined,analyzing their potential pharmacological,toxicological,or drug interaction effects through these mechanisms.Finally,a research paradigm is proposed that utilizes the gut microbiota as a link to interpret the role of these important natural products in BA signaling.

关 键 词：Bile acid TRITERPENOID PHYTOSTEROL SAPONIN Gut microbes CHOLESTASIS Metabolic disorders Rheumatoid arthritis 

分 类 号：R392[医药卫生—免疫学]