supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).
Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various...
supported by the National Key R and D Program of China(NO.2019YFA0905300);National Natural Science Foundation of China(No.32171477);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-001 and TSBICIP-PTJJ-007).
Cholesterol and phytosterols can be served as the substrates for Actinobacteria to produce the precursors used in the synthesis of steroidal medicines.Cytochrome P450s from CYP125 and CYP142 families initiates the met...
Coronary artery disease(CAD),a primary component of cardiovascular diseases,is one of the top contributors to mortality rates worldwide.In 2021,dietary risk was estimated to be attributed to 6.58 million cardiovascula...
This work was supported by the National Natural Science Foundation of China(No.31972110).
Encapsulation of phytosterols in nanostructured lipid carriers(NLCs)is an effective approach to improve their physicochemical properties,but the interaction of phytosterols in NLCs with cholesterol can be affected by ...
funded by Hunan Provincial Science Fund for Distinguished Young Scholars(2021JJ10007);the Research and Development Program in Key Areas of Hunan Province(2021NK2015,2020NK2027,2019SK2121);Hunan Scientific Talents Promotion Program supported by Hunan Association for Science and Technology(2019 TJ-Q01);the Research and Development Program in Key Areas of Hunan Province(2020NK2027).
The present study aimed to investigate the regulatory mechanisms of lotus seed core powder phytosterol extract(LSP-PE)on hypercholesterolemia and intestinal microbiota in high-cholesterol diet(HCD)-induced C57BL/6 J m...
The urgent and relevant goals of providing a healthier diet and sustainable food systems taken together require a systematic approach that considers a broader environment for food choice. The paper compares three tech...
supported by the National Natural Science Foundation of China(No.31972110)。
Phytosterols have received extensive attention owing to their excellent cholesterol-lowering activity and the role in cardiovascular diseases prevention. However, poor solubility in both oil and water limited the appl...
the National Natural Science Foundation of China(Nos.21776075 and 32100067);the Natural Science Founda-tion of Shanghai(No.20ZR1415100);the National Key Research and Development Program of China(No.SQ2020YFC210061);the China Postdoctoral Science Foundation(No.2020M671028),the Shanghai Municipal Health Commission(No.20204Y0380);the Teacher’s Professional Development Project of Shanghai Municipal Education Commission,and the Scientific Research Foundation of SUMHS.
Biotransformation of soybean phytosterols into 9α-hydroxy-4-androstene-3,17-dione(9-OHAD)by mycobacteria is the core step in the synthesis of adrenocortical hormone.However,the low permeability of the dense cell enve...
Project supported by the Jilin Province Research and Industrialization with Key Technologies for High Value Processing and Safety Control of Agricultural Products(No.SF2017-6-4);the Jilin Provincial Department of Education(No.JJKH20180172KJ),China
The ovum oil of forest frog has various health beneficial functions.In the current research,we evaluated the hypolipidemic effects of the low-cholesterol ovum oil from the forest frog and its combination with stigmast...
Phytosterols are a kind of active ingredients in plants with various physiological functions.Phytosterols have a good effect in antagonizing cholesterol and preventing cardiovascular diseases.They also have physiologi...