A notable impact of lipid matrices on cholesterol bioaccessibility from phytosterols-loaded nanostructured lipid carriers during in vitro intestinal digestion  

作　　者：Shujing Guo Chuanguo Ma Yuyuan Hu Zhenjia Song Tong Wang Ruinan Yang 

机构地区：[1]Lipid Technology and Engineering,College of Food Science and Engineering,Henan University of Technology,Lianhua Road 100,Zhengzhou,450001,Henan Province,PR China

出　　处：《Food Bioscience》2023年第2期1284-1292,共9页食品生物科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.31972110).

摘　　要：Encapsulation of phytosterols in nanostructured lipid carriers(NLCs)is an effective approach to improve their physicochemical properties,but the interaction of phytosterols in NLCs with cholesterol can be affected by lipid matrices.The objective of this study was to screen a desired phytosterols-loaded NLC(PS-NLC)formulation to reduce the absorption of intestinal cholesterol.A series of formulations were prepared using amphipathic glycerol monostearate(GMS)as the solid lipid fraction to increase lipid compatibity with phytosterols.All formulations showed a lowering effect on cholesterol bioaccessibility through in vitro intestinal digestion.And the PS-NLCs with medium chain triglycerides(MCT)as the liquid lipid showed significantly higher inhibition of cholesterol bioaccessibility(accessible fraction for intestinal absorption)than the formulations with long chain triglycerides(LCT),which could due to the solubilization of cholesterol by hydrolysis products of LCT,suggesting a notable impact of lipid type on cholesterol bioaccessibility.Furthermore,the analysis of distribution of phytosterols and cholesterol revealed a cocrystallization mechanism occurred during in vitro digestion.This study provides a certain reference for designing phytosterol-ingredient agents with a better hypocholesterolemic effect in water-dispersible functional foods.

关 键 词：Phytosterols Nanostructured lipid carriers Liquid lipid type Cholesterol bioaccessibility COCRYSTALLIZATION 

分 类 号：TS201[轻工技术与工程—食品科学]