CHOLESTASIS

作品数：234被引量：1099H指数：16
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相关机构：上海交通大学医学院附属第九人民医院解放军261医院北京军区总医院杭州市余杭区第二人民医院更多>>
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Genetic disorders leading to severe hyperlipidemia in children:A case report
《World Journal of Clinical Cases》2025年第16期60-66,共7页Chun-Xin Jiang Yu-Lin Meng Dong Chen Lian-Ping Shi Guang Yang Yang Guo Bo Zhang Zi-Chen Zhai Zhi-Jian Wu Tie-Nan Liu Zhi-Jun Wang Xiao Tian Peng-Yu Su 
Natural Science Foundation of Hebei Province,China,No.H2020209160;Scientific Research Projects in Chinese Medicine of Hebei Province,China,No.2019168.
BACKGROUND Alagille syndrome is a rare autosomal dominant genetic disorder involving multiple organ systems.Its most common manifestations are chronic cholestasis caused by intrahepatic bile duct deficiency and severe...
关键词：HYPERLIPIDEMIA Alagille syndrome Genetic mutation JAG1 CHOLESTASIS Low density lipoprotein cholesterol Traditional Chinese medicine Case report 
Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption
《World Journal of Gastroenterology》2025年第10期103-117,共15页Man Liu Ying-Lan Ji Yu-Jie Hu Ying-Xi Su Jie Yang Xiao-Yi Wang Hong-Yu Chu Xue Zhang Shi-Jing Dong Hui Yang Yu-Hang Liu Si-Min Zhou Li-Ping Guo Ying Ran Yan-Ni Li Jing-Wen Zhao Zhi-Guang Zhang Mei-Yu Piao Lu Zhou 
Supported by Tianjin Health Research Project,No.TJWJ2024QN005;Beijing iGandan Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-RGG122.
BACKGROUND Although an association between gut microbiota and cholestatic liver disease(CLD)has been reported,the precise functional roles of these microbes in CLD pathogenesis remain largely unknown.AIM To explore th...
关键词：CHOLESTASIS MICROBIOTA Lactococcus garvieae Intestinal permeability Bile acid 
Early plasmapheresis in type 2 benign recurrent intrahepatic cholestasis:A case report and review of literature
《World Journal of Hepatology》2025年第2期279-285,共7页Lander Heyerick Annemieke Dhondt Hans Van Vlierberghe Xavier Verhelst Sarah Raevens Anja Geerts 
BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive liver disease,causing episodic cholestasis with intense pruritus.This case report highlights the effectiveness of early plasmaphe...
关键词：CHOLESTASIS Benign recurrent intrahepatic 2 PLASMAPHERESIS PRURITUS CHOLESTASIS Bile salt export pump Case report 
Analysis of the etiology andclinical indicators of infantile cholestasis
《China Medical Abstracts(Internal Medicine)》2024年第4期221-221,共1页LI Qize 
Objective To explore the disease spectrum and corresponding clinical indicators of infantile cholestasis so as to provide a basis for the diagnosis of this type of disease at an early stage.Methods The clinical data w...
关键词：INFANTILE CHOLESTASIS Guiyang 
Endoscopic ultrasound-guided biliary drainage after failed endoscopic retrograde cholangiopancreatography: The road is open for almighty biliopancreatic endoscopists!
《World Journal of Gastrointestinal Surgery》2024年第9期2765-2768,共4页Filippo Antonini Ilenia Merlini Salomone Di Saverio 
Commentary on the article written and published by Peng et al,investigating the role of endoscopic ultrasound(EUS)-guided biliary drainage for palliation of malignant biliary obstruction after failed endoscopic retrog...
关键词：CHOLESTASIS Drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound ENDOSONOGRAPHY Endoscopic retrograde cholangiopancreatogra-phy Interventional procedures JAUNDICE Malignant Biliary obstruction 
The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications
《Acta Pharmaceutica Sinica B》2024年第8期3385-3415,共31页Zichen Luo Wei Zhou Tong Xie Weichen Xu Chen Shi Zihan Xiao Yu Si Yan Ma Qingling Ren Liuqing Di Jinjun Shan 
supported by the National Natural Science Foundation of China(grant numbers 82274071);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202208,China);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions;Qing Lan Project;Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction(ZX02102,China);NATCM’s Project of High-level Construction of Key TCM Disciplines;Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX23_2039,China).
Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various...
关键词：Bile acid TRITERPENOID PHYTOSTEROL SAPONIN Gut microbes CHOLESTASIS Metabolic disorders Rheumatoid arthritis 
STING-mediated IL-6 Inhibits OATP1B1 Expression via the TCF4 Signaling Pathway in Cholestasis
《Journal of Clinical and Translational Hepatology》2024年第8期701-712,共12页Yan Guo Hongjia Zhang Nan Zhao Ying Peng Dongya Shen Yubin Chen Xiaoxun Zhang Can-E Tang Jin Chai 
supported by grants from the National Natural Science Foundation of China(82325008,81974112,and 82370642);the Natural Science Foundation of Hunan Province(2024JJ5611);the Outstanding Medical Research Group of Chongqing(414Z381).
Background and Aims Organic anion-transporting polypeptides(OATPs)play a crucial role in the transport of bile acids and bilirubin.In our previous study,interleukin 6(IL-6)reduced OATP1B3 levels in cholestatic disease...
关键词：Inflammation Bile acid BILIRUBIN CHOLESTASIS STING IL-6 β-catenin TCF4 
Heritable Chronic Cholestatic Liver Diseases:A Review
《Journal of Clinical and Translational Hepatology》2024年第8期726-738,共13页Jasmine Tidwell George Y.Wu 
Chronic cholestasis due to heritable causes is usually diagnosedin childhood.However,many cases can present andsurvive into adulthood.The time course varies considerablydepending on the underlying etiology.Laboratory ...
关键词：Chronic cholestasis Cholestatic liver disease Congenital hepatic fibrosis Caroli disease Caroli syndrome Alagille syndrome Biliary atresia 
Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report
《World Journal of Clinical Cases》2024年第20期4427-4433,共7页Ya-Xin Xu Xiao-Xuan Niu Bei-Li Xu Yuan Ji Qun-Yan Yao 
BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-norma...
关键词：Benign recurrent intrahepatic cholestasis Genetic testing Psychosocial factors ATP8B1 gene mutation CHOLESTASIS JAUNDICE PRURITUS Case report 
Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia被引量：1
《World Journal of Gastrointestinal Oncology》2024年第6期2531-2540,共10页Jose Sebastiao dos Santos Vitor de Moura Arrais William Jose Rosseto Ferreira Ricardo Ribeiro Correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez Jose Celso Ardengh 
BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making i...
关键词：CHOLESTASIS JAUNDICE Obstructive BLASTOMYCOSIS Paracoccidioides Diagnosis Treatment 
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