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Inquiry of modulatory role of sea buckthorn fruit oil on dyslipidemia and gut microbiota in hyperlipidemia mice: 《Food Science and Human Wellness》2025年第4期1529-1537,共9页Pimiao Huang Zehua Chen Wenzi Li Aihua Su Chun Cui; supported by the National Natural Science Foundation of China(31201416);Programme of Introducing Talents of Discipline to Universities(B17018)。; Hyperlipidemia constitutes a critical factor in the pathogenesis of vascular disease and gut microbiota dysbiosis.This study aims to investigate the role of sea buckthorn fruit oil(SBFO)in ameliorating hyperlipidemia,...; 关键词：Sea buckthorn fruit oil HYPERLIPIDEMIA Gut microbiota Molecular mechanism

Genetic disorders leading to severe hyperlipidemia in children:A case report: 《World Journal of Clinical Cases》2025年第16期60-66,共7页Chun-Xin Jiang Yu-Lin Meng Dong Chen Lian-Ping Shi Guang Yang Yang Guo Bo Zhang Zi-Chen Zhai Zhi-Jian Wu Tie-Nan Liu Zhi-Jun Wang Xiao Tian Peng-Yu Su; Natural Science Foundation of Hebei Province,China,No.H2020209160;Scientific Research Projects in Chinese Medicine of Hebei Province,China,No.2019168.; BACKGROUND Alagille syndrome is a rare autosomal dominant genetic disorder involving multiple organ systems.Its most common manifestations are chronic cholestasis caused by intrahepatic bile duct deficiency and severe...; 关键词：HYPERLIPIDEMIA Alagille syndrome Genetic mutation JAG1 CHOLESTASIS Low density lipoprotein cholesterol Traditional Chinese medicine Case report

Analysis of the mechanism of Zangjiangzhi capsule in the treatment of hyperlipidemia based on its ingredients identified by UHPLC-Q-Exactive-Orbitrap-MS: 《Journal of Traditional Chinese Medical Sciences》2025年第1期44-55,共12页Changting He Yuling Zhao Yongchun Huang Yudong Su Shoude Zhang; supported by the National Natural Science Foundation of China(22067016);the Project of Qinghai Outstanding Youth Fund Project(2023-ZJ-964J).; Objective:To explore the mechanism of action of Zangjiangzhi capsule(ZJZC)in treating hyperlipidemia(HLP).Methods:The components of ZJZC were analyzed and identified using ultra-high performance liquid chromatography ...; 关键词：Zangjiangzhi capsule HYPERLIPIDEMIA UHPLC-MS/MS Network pharmacology Molecular docking Enzyme-linked immunosorbent assay

Tenofovir amibufenamide:A potential alternative for chronic hepatitis B treatment: 《World Journal of Gastroenterology》2025年第10期139-143,共5页Hai-Nan Ma Kai-Sen Cao Yan-Miao Liu Cheng Chen Hang Zhang Fu-Shan Tang; Tenofovir amibufenamide(TMF)is a novel prodrug of tenofovir that demonstrates a promising safety and efficacy profile.A recent study by Peng et al compared TMF with tenofovir alafenamide in the treatment of chronic he...; 关键词：Tenofovir amibufenamide Tenofovir alafenamide Chronic hepatitis B Antiviral efficacy Safety profile HYPERLIPIDEMIA

Exploring the mechanism of sea buckthorn polyphenols for the treatment of hyperlipidemia based on network pharmacology and molecular docking: 《Journal of Polyphenols》2025年第1期8-19,共12页Yizhuo Geng Lei Zhou Haimiao Chen Youdong Zhao Tingxu Yan Ying Jia; supported by 2024 Liaoning Province Graduate Education Teaching Reform Research Project(LNYJG2024251).; The aim of this study was to explore the mechanism of action of sea buckthorn polyphenols in the treatment of hyperlipidemia through network pharmacology and molecular docking.The TCMSP pharmacology database was used ...; 关键词：molecular docking network pharmacology sea buckthorn POLYPHENOL HYPERLIPIDEMIA

Fucoxanthin improves serum lipids,liver metabolism and gut microbiota in hyperlipidemia mice: 《Food Science and Human Wellness》2025年第1期236-249,共14页Yonghui Zhou Jingyi Zhang Kun Xu Weihao Zhang Feng Chen Bin Liu Bingbing Guo; funded by the National Natural Science Foundation of China(31901624);the Key-Area Research and Development Program of Guangdong Province(2018B020206001);Guangdong Province Zhujiang Talent Program(2019ZT08H476);Shenzhen Science and Technology Program(KQTD20180412181334790);the Innovation Team Project of Universities in Guangdong Province(2020KCXTD023)。; Fucoxanthin,a kind of exclusively algae-derived carotenoids,could reduce lipid content and regulate gut microbiota composition in obese mice,showing potential in preventing hyperlipidemia.This study aimed to illustrat...; 关键词：FUCOXANTHIN LIPIDS HYPERLIPIDEMIA Liver metabolism Gut microbiota

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract: 《Traditional Medicine Research》2025年第1期1-11,共11页Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang; supported by the Science and Technology Program of Tianjin in China(No.23ZYJDSS00030);the Public Applied Technology Research Project of Zhejiang Province(No.LGD22H090010)。; Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&E.H.Wilson in C.S.Sargent,and it in traditional Chinese medicine has been known for promoting blood circulation and removing bloo...; 关键词：HYPERLIPIDEMIA Sargentodoxae Caulis LIPIDOMICS intestinal flora

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis: 《Acta Pharmacologica Sinica》2024年第10期2119-2133,共15页Wei-zhi Wang Chao Liu Jin-que Luo Li-juan Lei Ming-hua Chen Yu-yan Zhang Ren Sheng Yi-ning Li Li Wang Xin-hai Jiang Tong-mei Xiao Yu-hao Zhang Shun-wang Li Ye-xiang Wu Yang Xu Yan-ni Xu Shu-yi Si; supported by grants from the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-030,2019-RC-HL-009);the National Natural Science Foundation of China(81973328);Xinjiang Uygur Autonomous Region Key Laboratory Open Project(2022D04017).; Proprotein convertase subtilisin/kexin type 9(PCSK9)binds to the epidermal growth factor precursor homologous domain A(EGF-A)of low-density lipoprotein receptor(LDLR)in the liver and triggers the degradation of LDLR v...; 关键词：ATHEROSCLEROSIS HYPERLIPIDEMIA PCSK9 inhibitor E28362 LDLR

Efficacy and safety of 10 mg/d vs.20 mg/d rosuvastatin in elderly patients with coronary heart disease and hyperlipidemia: 《South China Journal of Cardiology》2024年第3期149-155,共7页CHEN Hui-qin; Background Population aging has become a common concern in the world.coronary heart disease(CHD)is one of the major diseases that lead to the death of the elderly and affect the quality of life.Studies have confirmed ...; 关键词：Different doses ROSUVASTATIN Old age Coronary heart disease HYPERLIPIDEMIA

The Distribution Pattern of Traditional Chinese Medicine Syndromes in Patients with Hyperlipidemia: 《Journal of Biosciences and Medicines》2024年第9期173-182,共10页Bin Liang Luyao Wang Shaoxi Li Feifei Xue; Objective: Hyperlipidemia is a representative nutritional metabolic disease in clinic, which is easy to induce atherosclerotic cardiovascular and cerebrovascular diseases, with complex classification. Traditional Chin...; 关键词：COMPONENT HYPERLIPIDEMIA TCM Syndrome Differentiation EPIDEMIOLOGY Clinical Symptoms

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