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LDLR: 作品数：197被引量：599H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘萍郭航远池菊芳王建茹翟小亚更多>>; 相关机构：南华大学上海中医药大学重庆医科大学复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家科技支撑计划国家教育部博士点基金湖南省自然科学基金更多>>

Molecular basis for shifted receptor recognition by an encephalitic arbovirus: 《四川生理科学杂志》2025年第4期722-722,共1页Xiaoyi Fan; Western equine encephalitis virus(WEEV)is an arbovirus that historically caused large outbreaks of encephalitis throughout the Americas.WEEV binds protocadherin 10(PCDH10)as a receptor,and highly virulent ancestral WE...; 关键词：Cryoelectron microscopy Ldlr related proteins Western equine encephalitis virus Receptor recognition ARBOVIRUS mammalian receptors

ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR-/-hamsters: 《Genes & Diseases》2025年第2期136-139,共4页Yitong Xu Wenxi Zhang Jiabao Guo Jinxuan Chen Guolin Miao Lianxin Zhang Yufei Han Jingxuan Chen Ying Zhao Xunde Xian; supported by the National Natural Science Foundation of China (No.82070460,82270479,HY2021-1 to X.Xian);the Fundamental Research Funds for the Central Universities (China) (to X.Xian);the Beijing Natural Science Foundation (No.7242084 to X.Xian).; Apolipoprotein L1(ApoL1),coded by ApoL1 gene that is only expressed in humans,gorillas,and green monkeys,is largely synthesized by the liver and incorporated into highdensity lipoprotein(HDL),playing beneficial,roles ...; 关键词：ALLELE INFLAMMATION ATHEROSCLEROSIS

PCSK9抑制剂的心血管保护机制研究进展: 《临床医学进展》2025年第3期2192-2198,共7页李慧李飞; PCSK9抑制剂通过靶向调控低密度脂蛋白受体(LDLR)降解,已成为动脉粥样硬化性心血管疾病(ASCVD)治疗的革命性策略。本文结合国内外研究进展,从以下三方面进行系统阐述:1) 分子机制:PCSK9通过催化结构域与LDLR结合,介导其溶酶体降解,而抑...; 关键词：PCSK9抑制剂低密度脂蛋白受体(LDLR) 动脉粥样硬化性心血管疾病(ASCVD) RNA干扰疗法抗炎机制脂蛋白(a) [Lp(a)]

补骨脂素通过PCSK9/LDLR信号通路抗高脂饮食诱导的高脂血症研究: 《辽宁中医药大学学报》2024年第12期23-28,共6页刘婷罗雅歌毛浩萍马尚伟; 国家自然科学基金面上项目(82174180);天津市教委科研计划项目一般项目(2022KJ182)。; 目的基于前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexin type 9,PCSK9)探讨补骨脂素对高脂血症的影响及作用机制。方法首先使用分子对接法对补骨脂素与PCSK9蛋白结合能力进行预测。随后分别采用高脂饮食诱导的高脂...; 关键词：补骨脂素高脂血症 LDL摄取 PCSK9 LDLR

Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR^(-/-)Hamsters: 《Research》2024年第4期759-772,共14页Guolin Miao Jiabao Guo Wenxi Zhang Pingping Lai Yitong Xu Jingxuan Chen Lianxin Zhang Zihao Zhou Yufei Han Gonglie Chen Jinxuan Chen Yijun Tao Lemin Zheng Ling Zhang Wei Huang Yuhui Wang Xunde Xian; supported by the National Natural Science Foundation of China(NSFC)82070460,82270479,and HY2021-1 to X.X;the Fundamental Research Funds for the Central Universities to X.X.; Combined hyperlipidemia(CHL)manifests as elevated cholesterol and triglycerides,associated with fatty liver and cardiovascular diseases.Emerging evidence underscores the crucial role of the intestinal microbiota in me...; 关键词：CHOLESTEROL LDLR ELEVATED

STZ诱导联合高脂喂养LDLR^(-/-)小鼠糖尿病动脉粥样硬化模型的构建及评价: 《中国动脉硬化杂志》2024年第11期985-993,共9页王丽高金宁陈湘云姜沛青李梅步芳芳张梅姚桂华孙慧; 国家自然科学基金面上项目(81970282);青岛市临床重点专科建设项目(QDZDZK-2022008)。; [目的]构建糖尿病动脉粥样硬化小鼠模型,并研究该小鼠模型中糖尿病促动脉粥样硬化的病理特点。[方法]8周龄雄性LDLR^(-/-)小鼠50只,普脂饮食适应性喂养2周后改为高脂饮食,并随机分为两组,糖尿病动脉粥样硬化组采用小剂量链脲佐菌素(STZ...; 关键词：链脲佐菌素高脂饮食糖尿病动脉粥样硬化 LDLR^(-/-)小鼠

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis: 《Acta Pharmacologica Sinica》2024年第10期2119-2133,共15页Wei-zhi Wang Chao Liu Jin-que Luo Li-juan Lei Ming-hua Chen Yu-yan Zhang Ren Sheng Yi-ning Li Li Wang Xin-hai Jiang Tong-mei Xiao Yu-hao Zhang Shun-wang Li Ye-xiang Wu Yang Xu Yan-ni Xu Shu-yi Si; supported by grants from the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-030,2019-RC-HL-009);the National Natural Science Foundation of China(81973328);Xinjiang Uygur Autonomous Region Key Laboratory Open Project(2022D04017).; Proprotein convertase subtilisin/kexin type 9(PCSK9)binds to the epidermal growth factor precursor homologous domain A(EGF-A)of low-density lipoprotein receptor(LDLR)in the liver and triggers the degradation of LDLR v...; 关键词：ATHEROSCLEROSIS HYPERLIPIDEMIA PCSK9 inhibitor E28362 LDLR

基因检测早期诊断家族性高胆固醇血症一家系临床及遗传特点分析: 《实用医院临床杂志》2024年第5期17-21,共5页徐峰林凯俊丁远亮曹春艳杨康王柠林珉婷; 福建省财政厅项目2021年卫生健康省级专项补助经费《神经系统疾病生物样本库建设项目》(编号:BPB-LMT2021)。; 目的通过基因检测早期诊断家族性高胆固醇血症(familial hypercholesterolemia,FH)一家系,旨在提高临床医生对FH的识别及诊断能力,早期进行干预治疗。方法收集就诊于福建医科大学附属第一医院神经内科高胆固醇血症家系的临床资料,并进...; 关键词：家族性高胆固醇血症基因检测 LDLR

认识家族性高胆固醇血症: 《家庭医药（就医选药）》2024年第8期18-18,共1页蒲佳車顾超; 家族性高胆固醇血症(FH)是常见的孟德尔遗传病之一,其主要的并发症包括皮肤和肌腱的黄色瘤,冠状动脉疾病(CAD)等,这些症状主要和血浆低密度脂蛋白胆固醇(LDL-C)升高有关。FH已知的致病基因主要包括LDL受体(LDLR)、载脂蛋白B(APOB)、前...; 关键词：家族性高胆固醇血症黄色瘤冠状动脉疾病临床表型低密度脂蛋白胆固醇 LDLR APOB LDL受体

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets: 《Chinese Journal of Integrative Medicine》2024年第7期664-672,共9页LIU Su-su YU Tong QIAO Yan-fang GU Shu-xiao CHAI Xin-lou; Supported by National Science and Technology Major Special Project Based on Big Data Research and Development of New Chinese Medicine Drugs(No.2019ZX09201004-001-021)。; The prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia ca...; 关键词：HYPERLIPIDEMIA proprotein convertase subtilisin/kexin type 9 low-density lipoprotein receptor intracellular pathway extracellular pathway

LDLR