Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR^(-/-)Hamsters  

作　　者：Guolin Miao Jiabao Guo Wenxi Zhang Pingping Lai Yitong Xu Jingxuan Chen Lianxin Zhang Zihao Zhou Yufei Han Gonglie Chen Jinxuan Chen Yijun Tao Lemin Zheng Ling Zhang Wei Huang Yuhui Wang Xunde Xian 

机构地区：[1]Institute of Cardiovascular Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,School of Basic Medical Sciences,Peking University,Beijing,China [2]Beijing Key Laboratory of Cardiovascular Receptors Research,Peking University Third Hospital,Beijing,China

出　　处：《Research》2024年第4期759-772,共14页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(NSFC)82070460,82270479,and HY2021-1 to X.X;the Fundamental Research Funds for the Central Universities to X.X.

摘　　要：Combined hyperlipidemia(CHL)manifests as elevated cholesterol and triglycerides,associated with fatty liver and cardiovascular diseases.Emerging evidence underscores the crucial role of the intestinal microbiota in metabolic disorders.However,the potential therapeutic viability of remodeling the intestinal microbiota in CHL remains uncertain.In this study,CHL was induced in low-density lipoprotein receptordeficient(LDLR^(-/-))hamsters through an 8-week high-fat and high-cholesterol(HFHC)diet or a 4-month high-cholesterol(HC)diet.

关 键 词：CHOLESTEROL LDLR ELEVATED 

分 类 号：R57[医药卫生—消化系统]