Cholestasis in hepatitis E virus infection  

作　　者：Tatsuo Kanda Reina Sasaki-Tanaka Takeshi Yokoo Kazunao Hayashi Hiroteru Kamimura Atsunori Tsuchiya Shuji Terai 

机构地区：[1]Division of Gastroenterology and Hepatology,Uonuma Institute of Community Medicine,Niigata University Medical and Dental Hospital,Minamiuonuma 949-7302,Niigata,Japan [2]Division of Gastroenterology and Hepatology,Graduate School of Medical and Dental Sciences,Niigata University,Niigata 951-8520,Japan

出　　处：《World Journal of Hepatology》2025年第4期1-6,共6页世界肝病学杂志(英文)

基　　金：Supported by the Japan Agency for Medical Research and Development(AMED),No.JP24fk0210132(Kanda T,Sasaki-Tanaka R and Terai S);the JSPS KAKENHI,No.JP23K15055(Sasaki-Tanaka R).

摘　　要：Hepatitis E virus(HEV)infection causes acute hepatitis,chronic hepatitis,particularly in compromised hosts,and various extrahepatic manifestations.HEV infection is reportedly associated with biliary-pancreatic diseases,such as gallstones,cholangitis,choledocholithiasis,and acute pancreatitis.Severe jaundice and prolonged cholestasis are also atypical manifestations of HEV infection.The mechanism and genes involved in cholestasis,namely sinusoidal uptake of blood,bile salt synthesis and secretion from hepatocytes to the canaliculus,have been elucidated.HEV infection triggers severe jaundice and prolonged cholestasis in patients with genetic variants in adenosine triphosphatase phospholipid transporting 8B1,adenosine triphosphate-binding cassette(ABC)protein B4,ABCB11,Myosin VB,and/or farnesoid X receptor(FXR/NR1H4).Although prolonged cholestasis associated with these gene mutations does not seem to be specific to HEV infection,these mutations may be risk factors related to the severity of HEV infection.The use of the pregnane X receptor agonist rifampicin and the peroxisome proliferator-activated receptor activator bezafibrate may be useful for the treatment of cholestasis.These studies provide new insights into under-standing the mechanisms of severe jaundice and prolonged cholestasis caused by HEV infection.

关 键 词：Genomic mutations CHOLESTASIS Farnesoid X receptor Hepatitis E virus JAUNDICE 

分 类 号：R575.1[医药卫生—消化系统]