Steroids, Tri- and Meroterpenoids with a Quinone Structure—A Review  

作　　者：Maryam S. M. Aghaei Thies Thiemann Maryam S. M. Aghaei;Thies Thiemann(Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates)

机构地区：[1]Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates

出　　处：《International Journal of Organic Chemistry》2024年第1期32-68,共37页有机化学国际期刊（英文）

摘　　要：Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metabolites of estradiol and estrone are precursors of reactive quinones and semiquinones, which are thought to contribute to estrogen-induced carcinogenesis. On the other hand, a number of quinones that include substituted naphthoquinones and anthraquinones are highly cytotoxic and have been used in cancer treatment. This makes the structures interesting synthetic targets. The following is a review of important natural and synthetic terpenoid and steroid quinone hybrids.Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metabolites of estradiol and estrone are precursors of reactive quinones and semiquinones, which are thought to contribute to estrogen-induced carcinogenesis. On the other hand, a number of quinones that include substituted naphthoquinones and anthraquinones are highly cytotoxic and have been used in cancer treatment. This makes the structures interesting synthetic targets. The following is a review of important natural and synthetic terpenoid and steroid quinone hybrids.

关 键 词：STEROID Secosteroid Meroterpenoid TRITERPENOID QUINONE Anti-Tumour Agent Antibiotic Natural Product 

分 类 号：O62[理学—有机化学]