METABOLITES

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Fructose aggravating colon barrier dysfunction by decreasing gut bacteria metabolites indole-3-carboxaldehyde and inhibiting activation of aryl hydrocarbon receptor in vivo and in vitro
《Food Science and Human Wellness》2025年第4期1480-1497,共18页Ge Song Shaojie Pang Wenting Peng Wei Fang Yong Wang Rui Liu Qianyun Gan Wentao Qi 
supported by the Special Funds of Basic Research of Central Public Welfare Institute(JY2010 and ZX2410)。
Background:Fructose may induce non-alcoholic fatty acids(NAFLD)due to the gut-liver axis interactions.The mechanism of fructose impairing colon barrier is unrevealed.Methods:Normal and dextran sulfate sodium(DSS)-indu...
关键词：FRUCTOSE Tryptophan metabolites Colon barrier 
Polygonatum sibiricum saponin-lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism
《Food Science and Human Wellness》2025年第4期1514-1528,共15页Jiayuan Luo Mingjie Jia Shuang Liang Yangyang Chai Yihong Bao Shilong Jiang 
supported by National Natural Science Foundation of China(32000252);Natural Science Foundation of Heilongjiang Province of China(YQ2020C014,ZD2019C002);National Key Research and Development Program of China(2017YFC1601901)。
Some research have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus(T2DM)than a single intervention.However,there are still relatively few relevant repo...
关键词：PROBIOTICS Polygonatum sibiricum saponin Type 2 diabetes mellitus Gut microbiota METABOLITES 
Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus
《World Journal of Diabetes》2025年第5期135-147,共13页Ting-Ting Zheng Jia-He Liu Wan-Tong Huang Bo Hong Di Wang Chun-Yi Liu Jie Zhang Si-Si Li Shao-Wei Wu Qi Wang Lei Chen Lei Jin 
Supported by the National Key Research and Development Program of China,No.2021YFC2700700 and No.2021YFC2700704;Capital’s Funds for Health Improvement and Research(CFH)in People’s Republic of China,No.2020-1-5112.
BACKGROUND There are conflicting results on the potential correlation between folic acid and gestational diabetes mellitus(GDM),and the correlation between genetic factors related to folic acid metabolism pathways and...
关键词：Gestational diabetes mellitus Folate GENE Deoxyribonucleic acid Single nucleotide polymorphisms 
Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes
《World Journal of Diabetes》2025年第5期16-30,共15页Ling Xiong Ya-Xin Huang Lan Mao Yong Xu Yong-Qiong Deng 
Supported by Sichuan Provincial Department of Science and Technology Youth Fund Project,No.2024NSFSC1609;Sichuan Province Postdoctoral Special Funding Project,No.TB2023046。
Impaired healing of diabetic wounds is one of the most important complications of diabetes,often leading to lower limb amputations and incurring significant economic and psychosocial costs.Unfortunately,there are curr...
关键词：Type 2 diabetes Wound healing Gut microbiota Short chain fatty acids TRYPTOPHAN Bile acids Hydrogen sulfide 
Detection of Small Molecular Metabolites by Ambient Mass Spectrometry for Clinical Applications
《Chemical Research in Chinese Universities》2025年第2期181-195,共15页YE Jiali YIN Yiyan OUYANG Jin NA Na 
supported by the National Key Research and Development Program of China(No.2024YFA1509600);the National Natural Science Foundation of China(Nos.22474010,22274012);the Fundamental Research Funds for the Central Universities,China(No.2233300007).
Detection of small molecular metabolites in the body can reflect the overall health status of the human body, being essential for understanding metabolism and diagnosing diseases. For the detection and monitoring of s...
关键词：Ambient mass spectrometry Small molecular metabolite METABOLISM DISEASE 
Understanding the mechanism underlying the anti-inflammatory effect of dietary flavonoids on IBD:a focus on gut microbiota and its metabolites involved in SCFA,bile acid,tryptophan and lipopolysaccharides
《Food Science and Human Wellness》2025年第2期385-403,共19页Huihui Xiong Hui Chen Lingli Chen Kehui Ouyang Suyun Lin Wenjun Wang 
supported by grants from the National Natural Science Foundation of China(31560459);Jiangxi Provincial Natural Science Foundation(20224ACB205014);The Double Thousands Talents Plan of Jiangxi(jxsq2018102075,jxsq2018102076)。
Inflammatory bowel disease(IBD)is a chronic gastrointestinal disease with a high incidence.Treatment for IBD includes medications and diet,and common anti-inflammatory medications have limitations like drug resistance...
关键词：Dietary flavonoids Inflammatory bowel disease Gut microbiota METABOLITES Mechanisms 
Prevent effects of soybean meal peptides in acute alcoholic liver injury based on gut microbiota and metabolome alteration
《Food Science and Human Wellness》2025年第2期525-535,共11页Jingbo Liu Shengrao Li Qi Yang Siwen Lyu Xuanting Liu Zhiyang Du Xiaomin Shang Ting Zhang 
funded by the National Key R&D Program of China(2022YFD2101002);Jilin Province Science and Technology Youth Talent Support Project(QT202021);Fundamental Research Funds for the Central Universities。
This study investigated the preventive effects of soybean meal peptides(SPs)and their purification peptides(GTYW)on acute alcoholic liver injury.We combined the gut microbiota,metabolites,liver inflammation,and oxidat...
关键词：Soybean meal peptides Acute alcoholic liver injury Gut microbiota METABOLITES 
A Comparative Study on Gut Microbiota and Metabolomics in Atlantic Salmon Salmo salar at Different Growth Stages
《Journal of Ocean University of China》2025年第2期404-416,共13页WANG Bowen CAO Xiyu REN Wenhao ZHAO Chunyan LI Qing FAN Ruiyong MEN Xianhui ZHOU Yangen REN Yichao 
supported by the Key R&D Program of Shandong Province(No.2021LZGC027);the Shandong Provincial Natural Science Foundation(No.ZR202102250235);the Major Agricultural Application Technology Innovation Projects in Shandong Province(No.SD2019YY 006);the‘First Class Fishery Discipline’Program in Shandong Province,China。
Atlantic salmon(Salmo salar)represents the primary species in aquaculture.The gut microbiota plays a crucial role in nutrient processing and protection against pathogenic bacteria.Nonetheless,the composition and funct...
关键词：Atlantic salmon gut microbiota METABOLITES MICROBIOME metabolomics interaction mechanism muscle quality 
Gut microbiota plays a key role in the development of colorectal cancer
《World Journal of Gastroenterology》2025年第14期168-171,共4页Ying-Ling Liu Jie Liu 
Supported by Research Project of the Chinese Digestive Early Cancer Physicians'Joint Growth Program,No.GTCZ-2021-AH-34-0012.
This letter addresses the recently published manuscript by Darnindro et al,which investigates the diversity and composition of colonic mucosal microbiota in Indonesian patients with and without colorectal cancer(CRC)....
关键词：Colorectal cancer Gut microbiota Microbial dysbiosis Intratumoral microbiota Gut metabolites 
Roles of straw return in shaping denitrifying bacteria in rice rhizosphere soils through effects on root exudates and soil metabolites
《Soil Ecology Letters》2025年第1期39-51,共13页Pei Chen Yu Cheng Ning Wang Jian-Guang Yu Ying Zhao Li-Hong Xue 
supported by the National Key Research and Development Project of China(Grant No.2021YFD1700801);the Key Research and Development Project of Jiangsu Province(Grant No.D21YFD17008);the National Natural Science Foundation of China(Grant No.41601261).
Rhizosphere denitrification is affected by straw return.However,the roles of root exudates and soil metabolites in shaping denitrifying bacteria under wheat straw return are relatively unexplored.Here,wheat straw was ...
关键词：straw return denitrifying bacteria soil organic carbon root exudates METABOLITES 
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