DISEASE

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Copper homeostasis and neurodegenerative diseases
《Neural Regeneration Research》2025年第11期3124-3143,共20页Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang 
supported by the Notional Natural Science Foundation of Chino,No.82160690;Colloborotive Innovation Center of Chinese Ministry of Education,No.2020-39;Science and Technology Foundation of Guizhou Province,No.ZK[2021]-014(all to FZ)。
Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations.Copper homeostasis is...
关键词：Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease 
Childhood gastroesophageal reflux disease:A comprehensive review of disease,diagnosis,and therapeutic management
《World Journal of Clinical Pediatrics》2025年第2期38-46,共9页Daniyal Raza Farhan Mohiuddin Muhammad Haris Khan Maheen Fawad Syed Musa Raza 
Gastroesophageal reflux disease(GERD)affects both adults and children,although the symptoms differ significantly between these groups.While adults typically experience heartburn and regurgitation,children may present ...
关键词：Pediatric gastroesophageal reflux disease Gastroesophageal reflux disease Childhood reflux Gastroesophageal reflux disease diagnosis Gastroesophageal reflux disease management Pediatric gastrointestinal disorders©The Author(s)2025.Published 
Mitochondrial quality control in human health and disease
《Military Medical Research》2025年第3期393-458,共66页Bo‑Hao Liu Chen‑Zhen Xu Yi Liu Zi‑Long Lu Ting‑Lv Fu Guo‑Rui Li Yu Deng Guo‑Qing Luo Song Ding Ning Li Qing Geng 
supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...
关键词：Mitochondrial quality control(MQC) METABOLISM Programmed cell death CANCER Cardiovascular disease Metabolic disease Nervous disease Pulmonary disease Kidney disease Digestive system disease 
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
《Genes & Diseases》2025年第3期397-410,共14页Mingfeng Hu Qiling Xu Fang Zhang Karen F.Buckland Yelei Gao Weixia Du Yuan Ding Lina Zhou Xiulian Sun Lijia Ma Zhiyong Zhang Xuemei Tang Xiaodong Zhao Adrian J.Thrasher Yunfei An 
supported by the National Natural Science Foundation of China(No.82070135);the National Key R&D Program of China(No.2021YFC2700804);the CQMU Program for Youth Innovation in Future Medicine(China)(No.W0100).
X-linked severe combined immunodeficiency disease(X-SCID)is a rare inheriteddisease caused by mutations in the interleukin 2 receptor subunit gamma gene(IL2RG),whichencodes the common g chain protein,a subunit of the ...
关键词：Atypicaldiverse phenotype Gene therapy IL2RG Self-inactivating lentiviral vector X-linked severe combined immunodeficiency disease 
The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis
《Genes & Diseases》2025年第3期168-179,共12页Yinrui Li Bo Wang Yichao Zheng Huiqin Kang Ang He Lijuan Zhao Ningjie Guo Hongmin Liu Adil Mardinoglu M.A.A.Mamun Ya Gao Xiaobing Chen 
supported by the Basic Research of Medical Science and Technique Foundation of Henan Province,China(No.SBGJ202301004 to X.B.C.);the Key Project of the High Education from the Education Department of Henan Province,China(No.22ZX008 to Y.C.Z.);the Youth Supporting Program from Henan Province,China(No.2021HYTP060 to Y.C.Z.);the Youth Supporting Program from Zhengzhou University(No.JC202044046 to Y.C.Z.);the Science and Technology Project of Henan Province,China(No.232102311179 to Y.G.);the National Natural Science Foundation of China(No.U21A20416,82020108030 to H.M.L,82103997 to B.W.);the China Postdoctoral Science Foundation(No.2021M692950 to B.W.,2021M702942 to L.J.Z.).
Post-translational modifications(PTMs)of proteins play a crucial role in living organisms,altering the properties and functions of proteins.There are over 450 known PTMs involved in various life activities.LSD1(lysine...
关键词：Enzyme activity Histone demethylase Human diseases LSD1 POST-TRANSLATIONAL 
Leveraging Edge Optimize Vision Transformer for Monkeypox Lesion Diagnosis on Mobile Devices
《Computers, Materials & Continua》2025年第5期3227-3245,共19页Poonam Sharma Bhisham Sharma Dhirendra Prasad Yadav Surbhi Bhatia Khan Ahlam Almusharraf 
supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2025R432),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia。
Rapid and precise diagnostic tools for Monkeypox(Mpox)lesions are crucial for effective treatment because their symptoms are similar to those of other pox-related illnesses,like smallpox and chickenpox.The morphologic...
关键词：MONKEYPOX DISEASE classification local global TRANSFORMER 
Mango Disease Detection Using Fused Vision Transformer with ConvNeXt Architecture
《Computers, Materials & Continua》2025年第4期1023-1039,共17页Faten S.Alamri Tariq Sadad Ahmed S.Almasoud Raja Atif Aurangzeb Amjad Khan 
funded by Princess Nourah bint Abdulrahman University and Researchers Supporting Project number(PNURSP2025R346);Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
Mango farming significantly contributes to the economy,particularly in developing countries.However,mango trees are susceptible to various diseases caused by fungi,viruses,and bacteria,and diagnosing these diseases at...
关键词：ConvNeXt model fusion mango disease smart agriculture vision transformer 
Intralesional and topical treatments for Peyronie’s disease:a narrative review of current knowledge
《Asian Journal of Andrology》2025年第2期156-165,共10页Antonio Minore Loris Cacciatore Fabrizio Presicce Andrea Iannuzzi Antonio Testa Gianluigi Raso Rocco Papalia Marco Martini Roberto Mario Scarpa Francesco Esperto 
Peyronie’s disease(PD)presents a multifaceted challenge in contemporary urological practice,marked by penile deformity,pain,and the potential for erectile dysfunction.We meticulously explored the existing literature ...
关键词：COLLAGENASE induratio penis plastic INTERFERON intralesional/topical treatments penile traction Peyronie’s disease 
Detection of Small Molecular Metabolites by Ambient Mass Spectrometry for Clinical Applications
《Chemical Research in Chinese Universities》2025年第2期181-195,共15页YE Jiali YIN Yiyan OUYANG Jin NA Na 
supported by the National Key Research and Development Program of China(No.2024YFA1509600);the National Natural Science Foundation of China(Nos.22474010,22274012);the Fundamental Research Funds for the Central Universities,China(No.2233300007).
Detection of small molecular metabolites in the body can reflect the overall health status of the human body, being essential for understanding metabolism and diagnosing diseases. For the detection and monitoring of s...
关键词：Ambient mass spectrometry Small molecular metabolite METABOLISM DISEASE 
Multifaceted roles of UFMylation in health and disease
《Acta Pharmacologica Sinica》2025年第4期805-815,共11页Ru-na Wang Lin Li Jun Zhou Jie Ran 
supported by grants from the National Natural Science Foundation of China(32241014 and 32170687).
Ubiquitin fold modifier 1(UFM1)is a newly identified post-translational modifier that is involved in the UFMylation process.Similar to ubiquitination,UFMylation enables the conjugation of UFM1 to specific target prote...
关键词：UFMylation UFM1 post-translational modification DISEASE therapeutic target 
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