Childhood gastroesophageal reflux disease:A comprehensive review of disease,diagnosis,and therapeutic management  

作　　者：Daniyal Raza Farhan Mohiuddin Muhammad Haris Khan Maheen Fawad Syed Musa Raza 

机构地区：[1]Department of Internal Medicine,LSU Health Shreveport,Shreveport,LA 71103,United States [2]Department of Internal Medicine,LSU New Orleans,New Orleans,LA 70112,United States [3]Department of Psychiatry and Behavioral Health,LSU Health Shreveport,Shreveport,LA 71103,United States [4]Department of Gastroenterology and Hepatology,Deaconess Clinic,Henderson,KY 42420,United States

出　　处：《World Journal of Clinical Pediatrics》2025年第2期38-46,共9页世界临床儿科杂志(英文)

摘　　要：Gastroesophageal reflux disease(GERD)affects both adults and children,although the symptoms differ significantly between these groups.While adults typically experience heartburn and regurgitation,children may present with more subtle signs,such as failure to thrive,chronic cough,wheezing,and Sandifer syn-drome.Diagnosing GERD in children necessitates a multifaceted approach due to the diverse symptomatology and challenges in communication.Clinical assess-ment serves as the cornerstone of diagnosis,supported by tools like pH moni-toring,esophageal impedance testing,and upper gastrointestinal endoscopy.Imaging studies,such as barium swallow,can also provide valuable insights into anatomical abnormalities and the extent of reflux.Treatment strategies for pe-diatric GERD include lifestyle adjustments,pharmacotherapy,and,in severe cases,surgical interventions.Lifestyle adjustments may involve changes in fee-ding patterns,positional therapy,and weight management.Pharmacological options range from acid suppression with proton pump inhibitors or histamine-2 receptor antagonists to surgical procedures like fundoplication for refractory cases.Personalized management is essential,considering the child’s age,sym-ptom severity,and the presence of complications.This article aims to offer a comprehensive understanding of pediatric GERD by utilizing current research to enhance clinical approaches and improve patient outcomes.

关 键 词：Pediatric gastroesophageal reflux disease Gastroesophageal reflux disease Childhood reflux Gastroesophageal reflux disease diagnosis Gastroesophageal reflux disease management Pediatric gastrointestinal disorders©The Author(s)2025.Published 

分 类 号：R57[医药卫生—消化系统]