The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis  

作　　者：Yinrui Li Bo Wang Yichao Zheng Huiqin Kang Ang He Lijuan Zhao Ningjie Guo Hongmin Liu Adil Mardinoglu M.A.A.Mamun Ya Gao Xiaobing Chen 

机构地区：[1]Department of Oncology,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer,Zhengzhou,Henan 450008,China [2]State Key Laboratory of Esophageal Cancer Prevention&Treatment,Key Laboratory of Advanced Drug Preparation Technologies,Ministry of Education of China,Key Laboratory of Henan Province for Drug Quality Control and Evaluation,Zhengzhou,Henan 450001,China [3]Institute of Drug Discovery and Development,School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou,Henan 450001,China [4]Henan Institute of Medical and Pharmaceutical Sciences,State Key Laboratory for Esophageal Cancer Prevention and Treatment,Zhengzhou University,Zhengzhou,Henan 450001,China [5]Science for Life Laboratory,KTH e Royal Institute of Technology,Stockholm SE-10044,Sweden [6]Faculty of Dentistry,Oral&Craniofacial Sciences,Centre for Host-Microbiome Interactions,King’s College London,London WC2R 2LS,UK

出　　处：《Genes & Diseases》2025年第3期168-179,共12页基因与疾病(英文)

基　　金：supported by the Basic Research of Medical Science and Technique Foundation of Henan Province,China(No.SBGJ202301004 to X.B.C.);the Key Project of the High Education from the Education Department of Henan Province,China(No.22ZX008 to Y.C.Z.);the Youth Supporting Program from Henan Province,China(No.2021HYTP060 to Y.C.Z.);the Youth Supporting Program from Zhengzhou University(No.JC202044046 to Y.C.Z.);the Science and Technology Project of Henan Province,China(No.232102311179 to Y.G.);the National Natural Science Foundation of China(No.U21A20416,82020108030 to H.M.L,82103997 to B.W.);the China Postdoctoral Science Foundation(No.2021M692950 to B.W.,2021M702942 to L.J.Z.).

摘　　要：Post-translational modifications(PTMs)of proteins play a crucial role in living organisms,altering the properties and functions of proteins.There are over 450 known PTMs involved in various life activities.LSD1(lysine-specific demethylase 1)is the first identified histone demethylase that can remove monomethylation or dimethylation modifications from histone H3 lysine K4(H3K4)and histone H3 lysine K9(H3K9).This ability of LSD1 allows it to inhibit or activate transcription.LSD1 has been found to abnormally express at the protein level in various tumors, making it relevant to multiple diseases. As a PTM enzyme, LSD1 itself undergoes various PTMs, including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation, influencing its activity and function. Dysregulation of thesePTMs has been implicated in a wide range of diseases, including cancer, metabolic disorders,neurological disorders, cardiovascular diseases, and bone diseases. Understanding the speciesof PTMs and functions regulated by various PTMs of LSD1 provides insights into its involvementin diverse physiological and pathological processes. In this review, we discuss the structuralcharacteristics of LSD1 and amino acid residues that affect its enzyme activity. We also summarize the potential PTMs that occur on LSD1 and their involvement in cellular processes.Furthermore, we describe human diseases associated with abnormal expression of LSD1. Thiscomprehensive analysis sheds light on the intricate interplay between PTMs and the functionsof LSD1, highlighting their significance in health and diseases.

关 键 词：Enzyme activity Histone demethylase Human diseases LSD1 POST-TRANSLATIONAL 

分 类 号：R363[医药卫生—病理学]