POST-TRANSLATIONAL

作品数：40被引量：136H指数：6
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相关领域：生物学医药卫生更多>>
相关作者：罗嘉李学伟朱砺张顺华沈林園更多>>
相关机构：大连医科大学中国农业大学四川农业大学中国科学技术大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Advances in Microbiology》《遗传》《Molecular Plant》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划北京市自然科学基金广东省自然科学基金更多>>
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The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis
《Genes & Diseases》2025年第3期168-179,共12页Yinrui Li Bo Wang Yichao Zheng Huiqin Kang Ang He Lijuan Zhao Ningjie Guo Hongmin Liu Adil Mardinoglu M.A.A.Mamun Ya Gao Xiaobing Chen 
supported by the Basic Research of Medical Science and Technique Foundation of Henan Province,China(No.SBGJ202301004 to X.B.C.);the Key Project of the High Education from the Education Department of Henan Province,China(No.22ZX008 to Y.C.Z.);the Youth Supporting Program from Henan Province,China(No.2021HYTP060 to Y.C.Z.);the Youth Supporting Program from Zhengzhou University(No.JC202044046 to Y.C.Z.);the Science and Technology Project of Henan Province,China(No.232102311179 to Y.G.);the National Natural Science Foundation of China(No.U21A20416,82020108030 to H.M.L,82103997 to B.W.);the China Postdoctoral Science Foundation(No.2021M692950 to B.W.,2021M702942 to L.J.Z.).
Post-translational modifications(PTMs)of proteins play a crucial role in living organisms,altering the properties and functions of proteins.There are over 450 known PTMs involved in various life activities.LSD1(lysine...
关键词：Enzyme activity Histone demethylase Human diseases LSD1 POST-TRANSLATIONAL 
Expanding molecular diversity of ribosomally synthesized and post-translationally modified peptide(RiPP)natural products by radical S-adenosylmethionine(SAM)enzymes:recent advances and mechanistic insights
《Chinese Journal of Natural Medicines》2025年第3期257-268,共12页Jiawei Feng Jiarong Mo Xinya Hemu 
supported by the National Key Research and Development Program of China(No.2023YFA0916000);the National Natural Science Foundation of China(No.32371324);the High-level Talent Startup Fund provided by China Pharmaceutical University.
Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailorin...
关键词：Ribosomally synthesized and post-translationally modified peptides Radical S-adenosylmethionine Epimerization Methylation Side-chain cross-linking 
he BCM1-EGY1 module balances chlorophyll biosynthesis and breakdown to confer chlorophyll homeostasis in land plants
《Molecular Plant》2025年第1期76-94,共19页Dali Fu Hanlin Zhou Bernhard Grimm Peng Wang 
supported by funds from the Deutsche Forschungsgemeinschaft(FOR2092,GR 936/18-1,SFB TRR175,subproject C04,and WA 4599/2-2);the National Natural Science Foundation of China(Excellent Young Scientists Fund for Hong Kong and Macao,32322089);the Research Grant Council of Hong Kong(Early Career Scheme,27118022;and General Research Fund,17107223);the State Key Laboratory of Agrobiotechnology at the Chinese University of Hong Kong(the ITC Funding);the University of Hong Kong(the Seed Fund for Basic Research,66620211115918 and the Startup fund);Any opinions,findings,conclusions,or recommendations expressed in this publication do not reflect the views of the Government of the Hong Kong Special Administrative Region or the Innovation and Technology Commission.
Chlorophyll metabolism has evolved during plant evolution.The strictly light-dependent nature of chlorophyll biosynthesis found in angiosperms requires tight coordination of chlorophyll biosynthesis and breakdown to a...
关键词：chlorophyll homeostasis scaffold protein BCM1 proteolytic machinery EGY1 post-translational control 
Molecular Cloning and Bioinformatics Analysis of sucC Gene of Vibrio alginolyticus Strain HY9901
《Asian Agricultural Research》2024年第8期32-37,共6页Yingzhu WEI Zhiqing WEI Xuelian LIN Huanying PANG Na WANG 
Supported by National Natural Science Foundation of China(32073015);Graduate Education Innovation Program of Guangdong Province(YJYH[2022]1);Undergraduate Innovation and Entrepreneurship Training Program of Guangdong Ocean University(CXXL2024007);Undergraduate Innovation Team of Guangdong Ocean University(CCTD201802).
[Objectives]To clone the sucC gene of Vibrio alginolyticus strain HY9901 and conduct the bioinformatics analysis.[Methods]Based on the sucC gene of V.alginolyticus strain HY9901,specific primers were designed to ampli...
关键词：VIBRIO ALGINOLYTICUS GENE amplification sucC GENE Succinyl-Coa SYNTHETASE Protein POST-TRANSLATIONAL modification Bioinformatics analysis 
Substrate and Functional Diversity of Protein Lysine Post-translational Modifica
《Genomics, Proteomics & Bioinformatics》2024年第1期29-49,共21页Bingbing Hao Kaifeng Chen Linhui Zhai Muyin Liu Bin Liu Minjia Tan 
supported by grants from the Program of Shanghai Academic Research Leader(Grant No.22XD1420900);the National Natural Science Foundation of China(Grant Nos.22225702,32071432,32171434,and 81821005);the Youth Science and Technology Talents in Shanghai Sail Plan of China(Grant No.21YF1456000);the State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.KF-202201);the Guangdong High-level New R&D Institute,China(Grant No.2019B090904008);the Guangdong High-level Innovative Research Institute,China(Grant No.2021B0909050003).
Lysine post-translational modifications(PTMs)are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone proteins.Dysr...
关键词：Protein lysine PTM Regulatory enzyme PTM crosstalk Drug target ACYLATION 
Mechanistic Investigations into the Catalytic Mode of a Dehydratase Complex Involved in the Biosynthesis of Lantibiotic Cacaoidin被引量：1
《Chinese Journal of Chemistry》2023年第24期3579-3586,共8页Yanqing Xue Miao Li Ling Hu Jianing Liu Lifeng Pan Wen Liu 
supported in part by grants from the National Key Research and Development Program of China(2022YFC2303100 for L.P and W.L);the National Natural Science Foundation of China(32030002 and 22193070 for W.L);the Science and Technology Commission of Shanghai Municipality(20XD1425200 for L.P);the CAS Youth Interdisciplinary Team(JCTD-2022-10 for L.P).
Dehydration of serine/threonine residues necessitates the activity of a dehydratase enzyme(domain)during the biosynthesis of RiPP.Recently,it was reported that dehydration in the thioviridamide pathway relies on a dis...
关键词：Ribosomally synthesized and post-translationally modified peptide ANTIBIOTICS Enzyme models Natural products Dehydratase complex Cacaoidin Dehydration reaction 
Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering
《Synthetic and Systems Biotechnology》2022年第1期631-647,共17页Sebastian L.Wenski Sirinthra Thiengmag Eric J.N.Helfrich 
the LOEWE Center for Translational Biodiversity Genomics(LOEWE-TBG).
Complex peptide natural products exhibit diverse biological functions and a wide range of physico-chemical properties.As a result,many peptides have entered the clinics for various applications.Two main routes for the...
关键词：Peptide natural products Non-ribosomal peptide synthetases Ribosomally synthesized and post-translationally modified peptides BIOSYNTHESIS Modification Engineering 
Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling被引量：2
《Genomics, Proteomics & Bioinformatics》2022年第1期87-100,共14页Xinran Li Jiaqi Zhou Wenjuan Zhao Qing Wen Weijie Wang Huipai Peng Yuan Gao Kelly J.Bouchonville Steven M.Offer Kuiming Chan Zhiquan Wang Nan Li Haiyun Gan 
supported by the National Key R&D Program of China(Grant No.2019YFA0903803);the Major Program of National Natural Science Foundation of China(Grant No.32090031);the General Program of National Natural Science Foundation of China(Grant Nos.31971354 and 32070610);the National Natural Science Foundation of China for Young Scholars(Grant No.32000580);the Guangdong Province Fund for Distinguished Young Scholars,China(Grant No.2021B1515020109);the Key Project from Natural Science Foundation of Guangdong Province,China(Grant No.2020B1515120034);the Guangdong Provincial Key Laboratory of Synthetic Genomics,China(Grant No.2019B030301006);the Shenzhen Key Laboratory of Synthetic Genomics,China(Grant No.ZDSYS201802061806209);the Project from Shenzhen Science and Technology Innovation Committee,China(Grant No.JCYJ20170818164014753);the Mayo Clinic Cancer Center Eagles Cancer Fund awarded to ZW;the Mayo Clinic Cancer Center Hematologic Malignancies Program awarded to ZW;the Mayo Clinic division of Hematology awarded to ZW;the Mayo Clinic Center for Biomedical Discovery awarded to SMO,United States。
Proximity labeling catalyzed by promiscuous enzymes,such as APEX2,has emerged as a powerful approach to characterize multiprotein complexes and protein-protein interactions.However,current methods depend on the expres...
关键词：Proximity labeling Post-translationally AMAPEX Modified histone 
Challenges and advances in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs)被引量：4
《Synthetic and Systems Biotechnology》2020年第3期155-172,共18页Zheng Zhong Beibei He Jie Li Yong-Xin Li 
Z.Zhong,B.He,and Y-X Li acknowledge a partial financial support from the National Key R&D Program of China(2018YFA0903200);Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(SMSEGL20SC01);J.Li acknowledges a partial financial support by a National Institutes of Health(NIH)grant P20GM103641 and a National Science Foundation EPSCoR Program OIA-1655740.
Ribosomally synthesized and post-translationally modified peptides(RiPPs)are a class of cyclic or linear peptidic natural products with remarkable structural and functional diversity.Recent advances in genomics and sy...
关键词：Natural products Ribosomally synthesized and posttranslationally modified peptides RiPPs Genome mining Metagenome mining Synthetic biology 
Protein Phosphorylation and Phosphoproteome:An Overview of Rice被引量：5
《Rice science》2020年第3期184-200,共17页Abolore Adijat AJADI Amara CISSE Shakeel AHMAD WANG Yifeng SHU Yazhou LI Shufan LIU Xixi Babatunde Kazeem BELLO Sani Muhammad TAJO TONG Xiaohong ZHANG Jian 
Protein phosphorylation,one of the major post-translational modifications,plays a crucial role in cell signaling,DNA replication,gene expression and differentiation;and alters enzyme activity and other biological acti...
关键词：PHOSPHOPROTEOME PROTEIN PHOSPHORYLATION POST-TRANSLATIONAL MODIFICATION RICE 
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