supported by the Major Program of Guangdong Basic and Applied Research(2019B030302006);National Natural Science Foundation of China(32270752,31970531,32270292,32272509);Natural Science Foundation of Guangdong(2024A1515011071,2021A1515011151,2019A1515110330);Guangdong Modern Agro-industry Technology Research System(2023KJ114);the Program for Changjiang Scholars,and the Guangdong Special Support Program of Young Top-Notch Talent in Science and Technology Innovation(2019TQ05N651).
Geminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide.The homologs of C4(or L4)in monopartite geminiviruses and AC4(or AL4)in bipartite gemin...
supported by the National Key R&D Program of China(No.2022YFA1505400);the National Natural Science Foundation of China(Nos.21933005,21727803,22003005 and 22273007);the Fundamental Research Funds for the Central Universities(No.2233300007).
The photocatalytic decarboxylation ofα-keto acids to generate acyl radicals under mild conditions represents a novel strategy in organic synthesis.However,the quantum efficiency of this process has been underexplored...
supported by the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization,China (No.RERU2023006).
The laboratory-abundant and low-toxic ethyl acetate was explored successfully for the first time as acyl group donor for the Minisci-type acylation of quinolines.In this approach,TBAC/K_(2)S_(2)O_(8) (TBAC: tert-butyl...
supported by National Natural Science Foundation of China (NSFC);Youth program (Grant No: 22101173);Fundamental Research Funds for the Central Universities (23X010301599);“Thousand Talents Plan, Youth project”;startup funding from Shanghai Jiao Tong University (SJTU)。
Based on rational design, benzoyl cyanide, a well-known ionic acylating reagent, has been developed as a general radical acylating reagent for benzylic site-selective acylation reactions for the first time. Using visi...
support from the National Natural Science Foundation of China(Grant Nos.22371219,22193011,21971120,21933008 and 22101191);National Science&Technology Fundamental Resource Investigation Program of China(No.2018FY201200);the Fundamental Research Funds for the Central Universities.W.Z.is grateful for the financial support from the program of China Scholarship Council(No.202206240054).
Comprehensive Summary Phthalides serve as core structures pervasive in a wide array of natural products and drug molecules,which display a diverse array of biological activities.We report herein a highly efficient dyn...
supported by National Natural Science Foundation of China(32270805,31970332)。
Protein S-acylation or palmitoylation is a reversible post-translational modification that influences many proteins encoded in plant genomes.Exciting progress in the past 3 years demonstrates that S-acylation modulate...
support from the National Natural Science Foundation of China(21702013 and 22271010);the Fundamental Research Funds for the Central Universities(XK1802-6)at the BUCT.
A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(a...
the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042023kf0204);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).
Comprehensive Summary Currently,CRISPR/Cas9 technology has found widespread applications across various domains.However,the utility of CRISPR/Cas9 is encumbered by issues pertaining to its reliability and safety,prima...
the school level research projects of Changzhou University(No.ZMF23020007).
Comprehensive Summary A general and convenient photoredox-catalyzed acylation and alkylcyanation of MBH acetates has been established,enabling the assembly of the C(sp2)–C(sp3)bond by a nitrogen-centered radical stra...
supported by grants from the Program of Shanghai Academic Research Leader(Grant No.22XD1420900);the National Natural Science Foundation of China(Grant Nos.22225702,32071432,32171434,and 81821005);the Youth Science and Technology Talents in Shanghai Sail Plan of China(Grant No.21YF1456000);the State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.KF-202201);the Guangdong High-level New R&D Institute,China(Grant No.2019B090904008);the Guangdong High-level Innovative Research Institute,China(Grant No.2021B0909050003).
Lysine post-translational modifications(PTMs)are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone proteins.Dysr...