Visible-Light-Mediated Photocatalyst-Free Hydroacylation of Azodicarboxylic Acid Derivatives with 4-Acyl-1,4-dihydropyridines  

作　　者：Li Liu Jing Wang Xiaoying Feng Kun Xu Wei Liu Xia Peng Hongguang Du Jiajing Tan 

机构地区：[1]Department of Organic Chemistry,College of Chemistry,Beijing University of Chemical Technology,Beijing,100029 China [2]Sinopec Beijing Research Institute of Chemical Industry,Beijing,100013 China [3]Faculty of Environment and Life,Beijing University of Technology,Beijing,100124 China

出　　处：《Chinese Journal of Chemistry》2024年第11期1230-1236,共7页中国化学（英文版）

基　　金：support from the National Natural Science Foundation of China(21702013 and 22271010);the Fundamental Research Funds for the Central Universities(XK1802-6)at the BUCT.

摘　　要：A visible-light-enabled,photocatalyst-free hydroacylation reaction of azodicarboxylic acid derivatives was described.This radical conjugate addition(RCA)protocol relied on the dual role of 4-acyl-1,4-dihydropyridine(acyl-DHP)reagents that besides being as radical reservoirs,they also enabled the conversion of radical adducts to anion intermediates via reduction.Under“catalyst-oxidant-additive free”conditions,a wide range of structurally different acyl hydrazide products were readily obtained in 56%—99%yields.The utility of this transformation was further demonstrated by the scale-up synthesis and downstream derivatization.

关 键 词：Azo compounds Radicals ACYLATION 4-Acyl-1 4-dihydropyridine PHOTOCHEMISTRY 

分 类 号：O62[理学—有机化学]