Substrate and Functional Diversity of Protein Lysine Post-translational Modifica  

作　　者：Bingbing Hao Kaifeng Chen Linhui Zhai Muyin Liu Bin Liu Minjia Tan 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Tianjian Laboratory of Advanced Biomedical Sciences,Institute of Advanced Biomedical Sciences,Zhengzhou University,Zhengzhou 450001,China [4]Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan 528400,China [5]State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210023,China [6]Department of Cardiology,Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China [7]Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,College of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第1期29-49,共21页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by grants from the Program of Shanghai Academic Research Leader(Grant No.22XD1420900);the National Natural Science Foundation of China(Grant Nos.22225702,32071432,32171434,and 81821005);the Youth Science and Technology Talents in Shanghai Sail Plan of China(Grant No.21YF1456000);the State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.KF-202201);the Guangdong High-level New R&D Institute,China(Grant No.2019B090904008);the Guangdong High-level Innovative Research Institute,China(Grant No.2021B0909050003).

摘　　要：Lysine post-translational modifications(PTMs)are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone proteins.Dysregulation of lysine PTMs is implicated in many diseases,and targeting lysine PTM regulatory factors,including writers,erasers,and readers,has become an effective strategy for disease therapy.The continuing development of mass spectrometry(MS)technologies coupled with antibody-based affinity enrichment technologies greatly promotes the discovery and decoding of PTMs.The global characterization of lysine PTMs is crucial for deciphering the regulatory networks,molecular functions,and mechanisms of action of lysine PTMs.In this review,we focus on lysine PTMs,and provide a summary of the regulatory enzymes of diverse lysine PTMs and the proteomics advances in lysine PTMs by MS technologies.We also discuss the types and biological functions of lysine PTM crosstalks on histone and non-histone proteins and current druggable targets of lysine PTM regulatory factors for disease therapy.

关 键 词：Protein lysine PTM Regulatory enzyme PTM crosstalk Drug target ACYLATION 

分 类 号：Q51[生物学—生物化学]