KINASES

作品数：144被引量：554H指数：11
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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury
《Neural Regeneration Research》2025年第11期3233-3244,共12页Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang 
supported by the TARCC,Welch Foundation Award(I-1724);the Decherd Foundation;the Pape Adams Foundation,NIH grants NS092616,NS127375,NS117065,NS111776。
The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to b...
关键词：adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury 
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway
《World Journal of Gastrointestinal Oncology》2025年第3期270-290,共21页Zhuo-Cong Bao Zhao-Dong Liu Ye Zhang Hui-Jun Dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang 
the Central Government Guidance Local Science and Technology Development Fund,No.2023JH6/100100021;Liaoning Province Education Department Foundation of China,No.JYTMS20231393;Scientific Research Project of Liaoning Province Education Department,No.SYYX2019015;Science and Technology Fund of Shenyang Medical College,No.20171004,Shenyang Medical College Master’s Science and Technology Innovation Fund,No.Y20220509;Liaoning Provincial Department of Education Scientific Research Project,No.LJ212410164032.
BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in China.Herein,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a f...
关键词：Hepatocellular carcinoma TETRAHYDROCURCUMIN Network pharmacology Molecular docking PI3K/AKT signaling pathway 
Network pharmacology-based study on the mechanism of Tangfukang formula(糖复康方) against type 2 diabetes mellitus
《Journal of Traditional Chinese Medicine》2025年第1期76-88,共13页YAN Kai WANG Wei WANG Yan GAO Huijuan FENG Xingzhong 
Tsinghua Precision Medicine Foundation:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Patients with Qi and Yin Deficiency Syndrome by Regulating the Intestinal Flora Mediated Branched-chain Amino Acids-Phosphatidylinositide 3-Kinases-Protein Kinase B Signaling Pathway(grant number 10001020105);National Natural Science Foundation of China:Tangfukang Plays the Therapeutic Role in Type 2 Diabetes Mellitus by Regulating the Intestinal Flora Mediated Adiponectin-adenosine 5-Monophosphate-activated Protein Kinase-branched-chain Amino Acids Signaling Pathway(grant number 82104812)。
OBJECTIVE:To explore the mechanism of Tangfukang formula(糖复康方,TFK)in treating type 2 diabetes mellitus(T2DM).METHODS:We employed network pharmacology combined with experimental validation to explore the potential ...
关键词：network pharmacology diabetes mellitus type 2 AMP-activated protein kinase kinases signal transduction MECHANICS Tangfukang formula 
Synergy in Rice Immunity:Exploring Strategies of Coordinated Disease Defense Through Receptor-Like Kinases and Receptor-Like Cytoplasmic Kinases
《Rice science》2024年第6期643-658,共16页PEI Mengtian CAO Yingying XIE Xuze CAO Ying CHEN Jia ZHANG Xi WANG Zonghua LU Guodong ZHANG Shenghang 
supported by the National Natural Science Foundation of China (Grant No.U2005211);the Fuzhou General Teaching Hospital (the 900th Hospital)Key Project,China (Grant No.2022ZD01);the Fujian Clinical Research Center for Aptamer-based Precision Testing,China (Grant No.2021Y2017)。
Receptor-like kinases(RLKs)and receptor-like cytoplasmic kinases(RLCKs)play an indispensable role in the perception and transmission of extracellular signals in plants.In rice,these kinases actively participate in imm...
关键词：receptor-like kinase receptor-like cytoplasmic kinase pathogen-associated molecular pattern genetic breeding 
The symphony of maize signaling quartet defending against gray leaf spot
《Stress Biology》2024年第1期543-546,共4页Ping Wang Ping He 
support from the National Natural Science Foundation of China(32302370 to P.W.);USDA NIFA(grant 2020-67013-31615 to P.H.).
In plant immunity,a well-orchestrated cascade is initiated by the dimerization of receptor-like kinases(RLKs),followed by the phosphorylation of receptor-like cytoplasmic kinases(RLCKs)and subsequent activation of NAD...
关键词：Receptor-like kinases Receptor-like cytoplasmic kinases NADPH oxidase Grey leaf spot Pattern-triggered immunity 
Modified Sijunzi Granules Exhibit Hemostatic Effect by Activating Akt and Erk Signal Pathways via Regulating 5-HT and Its Receptors Levels
《Chinese Journal of Integrative Medicine》2024年第12期1121-1127,共7页WANG Jun ZHANG Xue-ying KANG Yan-hong ZHANG Yun CHEN Xin-yi ZHOU Jia-li MA Wei 
Supported by Natural Science Foundation of Zhejiang Province(No.LQ23H270001)。
Objective:To investigate the hemostatic effect of modified Sijunzi Granules(MSG)in primary immune thrombocytopenia(ITP)zebrafish model and explore the potential mechanism.Methods:AB strain wild type zebrafish were tre...
关键词：modified Sijunzi Granules Chinese medicine primary immune thrombocytopenia zebrafish 5-HYDROXYTRYPTAMINE 5-hydroxytryptamine receptor mitogen-activated protein kinase/extracellular regulated protein kinases signal pathway phosphoinositide3-kinases/protein kinase B signal pathway 
Mouse KL2 is a unique MTSE involved in chromosome-based spindle organization and regulated by multiple kinases during female meiosis
《Journal of Biomedical Research》2024年第5期485-499,I0009-I0011,共18页Shiya Xie Yanjie Yang Zhen Jin Xiaocong Liu Shuping Zhang Ning Su Jiaqi Liu Congrong Li Dong Zhang Leilei Gao Zhixia Yang 
supported by the Youth Program of National Natural Science Foundation of China(Grant No.82001539 to Leilei Gao);the Zhejiang Province Health Innovation Talent Project(Grant No.2021RC001 to Zhen Jin);the General Program of the National Natural Science Foundation of China(Grant No.31671561 to Dong Zhang);the Regional Program of National Natural Science Foundation of China(Grant No.82260126 to Xiaocong Liu).
Microtubule-severing enzymes(MTSEs)play important roles in mitosis and meiosis of the primitive organisms.However,their roles in mammalian female meiosis,which accounts for over 80%of gamete-originated human reproduct...
关键词：MOUSE KL2 MTSE KINASE female meiosis 
Protein S-acylation,a new panacea for plant fitness
《Journal of Integrative Plant Biology》2024年第10期2102-2108,共7页Fei Liu Jin-Yu Lu Sha Li Yan Zhang 
supported by National Natural Science Foundation of China(32270805,31970332)。
Protein S-acylation or palmitoylation is a reversible post-translational modification that influences many proteins encoded in plant genomes.Exciting progress in the past 3 years demonstrates that S-acylation modulate...
关键词：biotic and abiotic stresses FEEDBACK KINASES protein turnover RECEPTOR subcellular localization 
Modulation of synaptic damage by Bushen Tiansui Decoction via the PI3K signaling pathway in an Alzheimer’s disease model
《Digital Chinese Medicine》2024年第3期284-293,共10页HUI Shan ZHENG Qing LI Hongli ZHU Lemei WU Beibei LIANG Lihui YANG Jingjing 
Hunan Provincial Natural Science Foundation of China(2022JJ40220);Health Commission of Hunan Province(B202303106781);Hunan Administration of Traditional Chinese Medicine(2021192).
Objective To explore the therapeutic effect and mechanism of Bushen Tiansui Decoction(补肾填髓方,BSTSD)and its active component icariin on Alzheimer’s disease(AD).Methods(i)Animal experiments.This study conducted exp...
关键词：Alzheimer’s disease(AD) Synapses Bushen Tiansui Decoction(补肾填髓方 BSTSD) ICARIIN Phosphoinostitide 3-kinases(PI3K) 
Ubiquitination-mediated regulation of receptor-like kinases in symbiosis and immunity
《Molecular Plant》2024年第9期1335-1337,共3页David Landry Benoit Lefebvre 
Receptor-like kinases(RLKs)are plasma membrane(PM)proteins that monitor the extracellular environment and regulate various processes such as biotic interactions.Lysin motif(LysM)RLKs are a specific class of RLKs invol...
关键词：EXTRACELLULAR IMMUNITY KINASES 
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