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作品数：739被引量：2941H指数：21
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相关领域：医药卫生生物学更多>>
相关作者：陈珈王学臣王勇博程涵马向东更多>>
相关机构：华中科技大学中国科学院中国医科大学吉林大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury
《Neural Regeneration Research》2025年第11期3233-3244,共12页Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang 
supported by the TARCC,Welch Foundation Award(I-1724);the Decherd Foundation;the Pape Adams Foundation,NIH grants NS092616,NS127375,NS117065,NS111776。
The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to b...
关键词：adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury 
Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第11期135-152,共18页Yi Wu Bin-Bin Xie Bing-Liang Zhang Qing-Xin Zhuang Shi-Wei Liu Hong-Ming Pan 
Supported by the National Natural Science Foundation of China,No.82100542 and No.81802842.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive malignancy in the Chinese population;the severe vascularization by the tumor makes it difficult to cure.The high incidence and poor survival rates ...
关键词：Apatinib Hepatocellular carcinoma Vascular endothelial cells GLYCOLYSIS Phosphatidylinositol 3-kinase Protein kinase B 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 
Lrrk2 promotes M1 macrophage polarization via regulating cytokine(IFN-g)and TLR4(LPS)-mediated responses
《hLife》2025年第2期98-111,I0001-I0005,共19页Yuchen Kang Ping Gao Xiaotong Chen Xiaoyu Zhai Xi Wang Xiaojuan Han Baoqian Jia Baidong Hou Xuyu Zhou Jian Song Fuping Zhang 
supported by a National Key Research and Development Project Grant(2021YFC2300502);the National Natural Science Foundation of China Grants(32370930 and 32360176).
Leucine-rich repeat kinase 2(Lrrk2)has received widespread attention as a risk gene associated with Parkinson’s disease.As the immune response attributes of Parkinson’s disease have been gradually revealed,the link ...
关键词：leucine-rich repeat kinase 2(Lrrk2) M1 macrophage signal transducer and activator of transcription 1(STAT1) 
Melanoma cell line-derived exosomal miR-424-5p:a key promoter of angiogenesis through LATS2 interaction
《Oncology Research》2025年第2期357-367,共11页JUNWEI DU QIANG ZHANG JING ZHANG MAIERDANJIANG MAIHEMUTI HAIYANG HE RENBING JIANG 
Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01C803).
Objectives:Melanoma is a highly aggressive and metastatic form of cancer,and the role of exosomal microRNAs(miRNAs)in its progression remains largely unexplored.This study aimed to investigate the effects of melanoma ...
关键词：Exosomal miR-424-5p Large tumor suppressor kinase 2(LATS2) Cell proliferation Cancer progression Therapeutic targets 
Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway
《World Journal of Diabetes》2025年第2期163-174,共12页Sheng-Xi Xiong Lin-Juan Huang Han-Shuang Liu Xiao-Xiao Zhang Min Li Yu-Bing Cui Chen Shao Xiao-Lei Hu 
Natural Science Foundation of Anhui Province,No.2208085MH216;Major Natural Science and Technology Project of Bengbu Medical College,No.2020byfy004;Scientific Research Program of Anhui Provincial Health Commission,No.AHWJ2023BAc10028.
BACKGROUND Macrophages are central to the orchestration of immune responses,inflammatory processes,and the pathogenesis of diabetic complications.The dynamic polarization of macrophages into M1 and M2 phenotypes criti...
关键词：DAPAGLIFLOZIN Macrophage polarization INFLAMMATION Macrophage apoptosis Phosphoinositide 3-kinase/protein kinase B signaling pathway 
Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells
《World Journal of Diabetes》2025年第2期175-182,共8页Hao-Yan Li Yi Wang Min Ran Fei Gao Bo-Yu Zhu Hai-Ying Xiao Chun Xu 
BACKGROUND Tacrolimus(FK506)is a key calcineurin inhibitor used to prevent organ transplant rejection and is effective in improving graft survival.However,it is linked to hyperglycemia and insulin resistance,contribut...
关键词：TACROLIMUS Insulin resistance DYSLIPIDEMIA Ribosomal protein S6 kinase beta-1 Glucose metabolism 
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
《Acta Pharmaceutica Sinica B》2025年第1期438-466,共29页Yang Li Yan Fang Xiaoyu Chen Linjiang Tong Fang Feng Qianqian Zhou Shulun Chen Jian Ding Hua Xie Ao Zhang 
support from the China National Innovation of Science and Technology-2030(Program of Brain Science and Brain-Inspired Intelligence Technology,2021ZD0204004);the National Natural Science Foundation of China(Grants Nos.82273767,82073073,82122045,and 82273948);the Major Projects for Shanghai Zhang jiang National Independent Innovation of China(ZJ2021-ZD-007);Innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20210802,China);the Project of Shanghai Institute of Materia Medica,CAS(SIMM0120231001,China);the High-level Innovative Research Institute,Department of Science and Technology of Guangdong Province(2021B0909050003,China).
The p21-activated kinase 4(PAK4),a key regulator of malignancy,is negatively correlated with immune infiltration and has become an emergent drug target of cancer therapy.Given the lack of high efficacy PAK4 inhibitors...
关键词：P21-activated kinase 4 Tetrahydrobenzofuro[2 3-clpyridine Structure-activity relationship Allosteric inhibitor Pharmacokinetics properties 
RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition
《World Journal of Gastroenterology》2025年第2期113-127,共15页Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng Zhu 
Supported by the Fundamental Research Program of Shanxi Province,No.202203021222418;Research Program of Shanxi Provincial Health Commission,No.2023061;Fundamental Research Cooperation Program of Beijing-Tianjin-Hebei Region of Natural Science Foundation of Tianjin,No.22JCZXJC00140;Tianjin Major Science and Technology Project,No.21ZXJBSY00110;Tianjin Health and Science and Technology Project,No.TJWJ2024ZK001.
BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G proteins.The speci-fic effect of RGS,particularly RGS4,on the progr...
关键词：Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition 
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
《World Journal of Stem Cells》2025年第1期22-39,共18页Jing Yang Jun Yuan Yan-Qing Wen Li Wu Jiu-Jiang Liao Hong-Bo Qi 
support from the“111 program”of Ministry of Education of China and State Administration of Foreign Experts Affairs of China.
BACKGROUND Uterine injury can cause uterine scarring,leading to a series of complications that threaten women’s health.Uterine healing is a complex process,and there are currently no effective treatments.Although our...
关键词：Uterine injury Bone marrow mesenchymal stem cells Uterine smooth muscle cells Phosphoinositide 3-kinase/protein kinase B pathway Cell-cell interactions Cell proliferation Immune regulation Wound regeneration 
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