TETRAHYDROCURCUMIN

作品数：8被引量：22H指数：2
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Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology
《World Journal of Gastrointestinal Oncology》2025年第3期221-236,共16页Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-Jun Dai Fu Ren Ning Li Shang-Yu Lv Yan Zhang 
The Central Government Guides Local Science and Technology Development Fund,No.2023JH6/100100021;Liaoning Province Education Department Foundation of China,No.JYTMS20231393 and No.LJ212410164032;Scientific Research Project of the Liaoning Province Education Department,No.SYYX2019015;Science and Technology Foundation of Shenyang Medical College,No.20171004;the Science and Technology Innovation Fund for Master Students of Shenyang Medical College,No.Y20220509.
BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality worldwide.This study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocur...
关键词：Hepatocellular carcinoma cells TETRAHYDROCURCUMIN TP53 Network pharmacology Molecular docking 
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway
《World Journal of Gastrointestinal Oncology》2025年第3期270-290,共21页Zhuo-Cong Bao Zhao-Dong Liu Ye Zhang Hui-Jun Dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang 
the Central Government Guidance Local Science and Technology Development Fund,No.2023JH6/100100021;Liaoning Province Education Department Foundation of China,No.JYTMS20231393;Scientific Research Project of Liaoning Province Education Department,No.SYYX2019015;Science and Technology Fund of Shenyang Medical College,No.20171004,Shenyang Medical College Master’s Science and Technology Innovation Fund,No.Y20220509;Liaoning Provincial Department of Education Scientific Research Project,No.LJ212410164032.
BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in China.Herein,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a f...
关键词：Hepatocellular carcinoma TETRAHYDROCURCUMIN Network pharmacology Molecular docking PI3K/AKT signaling pathway 
Progress of research on tetrahydrocurcumin against liver injury
《Gastroenterology & Hepatology Research》2023年第3期40-46,共7页Ke-Yu Chen Shuang Luo Yun-Teng Liu Xue Wang Jian-Bo Wang 
supported by Key Program of Natural Science Foundation of Sichuan Province of China(2023NSFSC0040).
Liver injury has become a serious liver disease worldwide,and its incidence is increasing year by year,bringing a serious health burden to people in all countries.Tetrahydrocurcumin is an active metabolite of curcumin...
关键词：TETRAHYDROCURCUMIN active structure pharmacological effects liver injury 
Tetrahydrocurcumin as a stable and highly active curcumin derivative:A review of synthesis,bioconversion,detection and application
《Food Bioscience》2023年第3期107-116,共10页Linjiang Zhu Yuting Xue Jiacheng Feng Yuxin Wang Yuele Lu Xiaolong Chen 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY19B060008);the Zhejiang Provincial Key Research Program of China(Grant 2019C02088).
Tetrahydrocurcumin(THCu)is one of the major reduction metabolites of curcumin(CUR),which is a well-known yellow food pigment from turmeric with strong antioxidant,anti-inflammatory,and antibacterial properties.THCu ex...
关键词：CURCUMIN TETRAHYDROCURCUMIN Bioconversion REDUCTASE Natural product 
Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities被引量：1
《Journal of Pharmaceutical Analysis》2020年第4期334-345,共12页Mahendra Kumar Trivedi Parthasarathi Panda Kalyan Kumar Sethi Mayank Gangwar Sambhu Charan Mondal Snehasis Jana 
Dabur Research Foundation,New Delhi,India
Tetrahydrocurcumin(THC)is one of the major metabolites of curcumin(CUR),an ancient bioactive natural polyphenolic compound.This research article describes both the solid and liquid state characterization of THC using ...
关键词：TETRAHYDROCURCUMIN Liquid chromatography-mass spectrometry Spectroscopic and thermal analysis Keto-enol tautomer ANTI-INFLAMMATORY Antioxidant 
Synthesis and Cytotoxic Activity of Novel Tetrahydrocurcumin Derivatives Bearing Pyrazole Moiety被引量：2
《Natural Products and Bioprospecting》2017年第6期461-469,共9页Ahmed Mahal Ping Wu Zi-Hua Jiang Xiaoyi Wei 
supported by National Natural Science Foundation of China(NSFC)(Grant No.81172942).
Tetrahydrocurcumin(THC)is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects.THC is a promising preventive and chemotherapeutic agent for cancer.A series of new pyrazole ...
关键词：CONDENSATION TETRAHYDROCURCUMIN PYRAZOLE Anticancer agents Drug discovery 
Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA被引量：2
《Acta Pharmacologica Sinica》2008年第7期853-860,共8页Supachai YODKEEREE Spiridione GARBISA Pornngarm LIMTRAKUL 
Aim： Tetrahydrocurcumin （THC） is an active metabolite of curcumin. It has been reported to have similar pharmacological activity to curcumin. The proteases that participate in extracellular matrix （ECM） degradati...
关键词：TETRAHYDROCURCUMIN invasion MATRIXMETALLOPROTEINASES urokinase plasminogenactivator 
Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice被引量：19
《World Journal of Gastroenterology》2008年第13期2003-2009,共7页Pornprom Yoysungnoen Ponthip Wirachwong Chatchawan Changtam Apichart Suksamrarn Suthiluk Patumraj 
The Thailand Research Fund, No. MRG4980032;partially supported by The National Center for Genetic Engineering and Biotechnology, Thailand
AIM: To determine the effect of tetrahydrocurcumin (THC) on tumor angiogenesis compared with curcumin (CUR) by using both in vitro and in vivo models of human hepatocellular carcinoma cell line (HepG2). METHODS: The 3...
关键词：Tumor angiogenesis HepG2 CURCUMIN TETRAHYDROCURCUMIN Intravital fluorescence videomicroscopy 
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