ICARIIN

作品数：90被引量：425H指数：14
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相关领域：医药卫生更多>>
相关作者：崔振伟杨述华王晶刘先哲叶树楠更多>>
相关机构：华中科技大学郑州大学天津中医药大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system:current status and future perspective
《Asian Journal of Andrology》2025年第1期20-29,共10页Song-Po Liu Yun-Fei Li Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan Ji Cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan Ji-Dong Zhang 
supported by the National Nature Science Foundation of China(NSFC,No.31960156,No.31660338,No.31760627,and No.32270848);Collaborative Innovation Center of Chinese Ministry of Education(2020-39),Science and Technology Support Program of Guizhou Province(QKH[2021]111,QKH[2020]4Y192,QKH[2018]5772-006,and QKH[2019]5406);Science and Technology Fund of Guizhou Provincial Health Commission(gzwkj2022-019).
Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research a...
关键词：EPIMEDIUM ICARIIN INFERTILITY male reproductive system TUMOR 
WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells
《World Journal of Stem Cells》2025年第2期68-83,共16页Yi Wang Feng-Qiu Zhang Zhi-Peng Fan Xin-Ling Zhu Wan-Hao Yan Xiu-Li Zhang 
Beijing Natural Science Foundation,No.7192076.
BACKGROUND Periodontitis is an inflammatory disease caused by the host’s immune response and various interactions between pathogens,which lead to the loss of connective tissue and bone.In recent years,mesenchymal ste...
关键词：Periodontal ligament stem cells Periodontal tissue regeneration ICARIIN WD repeat-containing protein 36 Osteogenic differentiation 
A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy
《Chinese Chemical Letters》2025年第1期267-271,共5页Chao Zhang Ai-Feng Liu Shihui Li Fang-Yuan Chen Jun-Tao Zhang Fang-Xing Zeng Hui-Chuan Feng Ping Wang Wen-Chao Geng Chuan-Rui Ma Dong-Sheng Guo 
supported by grants from the National Natural Science Foundation of China(Nos.82374489,U20A20259 and 22201299);the Scientific Research Program of the Tianjin Municipal Education Commission(No.2021ZD013)。
Osteoarthritis(OA)is the most prevalent joint disease and icariin is a promising drug for its treatment.However,the clinical use of icariin is hindered by poor water solubility,low bioavailability,and nonspecific rele...
关键词：Biomaterial Supramolecular chemistry CALIXARENE ICARIIN OSTEOARTHRITIS 
Modulation of synaptic damage by Bushen Tiansui Decoction via the PI3K signaling pathway in an Alzheimer’s disease model
《Digital Chinese Medicine》2024年第3期284-293,共10页HUI Shan ZHENG Qing LI Hongli ZHU Lemei WU Beibei LIANG Lihui YANG Jingjing 
Hunan Provincial Natural Science Foundation of China(2022JJ40220);Health Commission of Hunan Province(B202303106781);Hunan Administration of Traditional Chinese Medicine(2021192).
Objective To explore the therapeutic effect and mechanism of Bushen Tiansui Decoction(补肾填髓方,BSTSD)and its active component icariin on Alzheimer’s disease(AD).Methods(i)Animal experiments.This study conducted exp...
关键词：Alzheimer’s disease(AD) Synapses Bushen Tiansui Decoction(补肾填髓方 BSTSD) ICARIIN Phosphoinostitide 3-kinases(PI3K) 
Bibliometric analysis of 100 most-cited papers on Icariin
《Pharmacology Discovery》2024年第3期36-47,共12页Lin Mao Yi-Feng Shen Kun Zhu Jun-Long Zhu Xiao-Peng Huang De-Gui Chang Yao-Dong You Dong-Dong Yang 
supported by the Natural Science Foundation of Sichuan Province(2023NSFSC1799);the Science and Technology Development Fund of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(21ZS05,23YY07).
Icariin is the most prevalent component of the medicinal herb Herba Epimedii.Icariin exhibits many medicinal properties,including anti-cancer impact and osteoprotective and neuroprotective effects.The goal of this stu...
关键词：ICARIIN Herba Epimedii VOSviewer BIBLIOMETRICS 
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening
《Current Medical Science》2024年第4期748-758,共11页Shan-shan HU Tong-yao WANG Lu NI Fan-xin HU Bo-wen YUE Ying ZHENG Tian-lun WANG Abhishek KUMAR Yan-yan WANG Jin-e WANG Zhi-yong ZHOU 
supported by the Natural Science Foundation of Yichang City of China(No.A23-1-075).
Objective Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging rats.Mitochondrial dysfunction is associated with brain aging-related neurodegenerative diseases.A...
关键词：ICARIIN neuronal injury mitochondrial dysfunction mitochondrial permeability transition pore AUTOPHAGY 
Abalone shell-derived Mg-doped mesoporous hydroxyapatite microsphere drug delivery system loaded with icariin for inducing apoptosis of osteosarcoma cells
《Biomaterials Translational》2024年第2期185-196,共12页Kaihua Liu Meiqi Cheng Hao Huang Hui Yu Shiyao Zhao Jinnuo Zhou Dan Tie Jianhua Wang Panpan Pan Jingdi Chen 
supported by Open Foundation of State Key Laboratory of Mineral Processing(No.BGRIMM-KJSKL-2023-23);Shandong Laboratory of Advanced Materials and Green Manufacturing(No.AMGM2021F02);Natural Science Foundation of Shandong Province(Nos.ZR2022QD057,ZR2023MC125);Open Project Fund for Hubei Key Laboratory of Oral and Maxillofacial Development and Regeneration(No.2021kqhm003);China Postdoctoral Science Foundation(Nos.2022M722434,2023T160492).
Hydroxyapatite(HAP)porous microspheres with very high specific surface area and drug loading capacity,as well as excellent biocompatibility,have been widely used in tumour therapy.Mg^(2+)is considered to be a key fact...
关键词：abalone shell drug delivery hydroxyapatite microspheres magnesium doping OSTEOSARCOMA 
Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats
《Chinese Journal of Natural Medicines》2024年第4期293-306,共14页YAO Wenhui TAO Rongpin WANG Kai DING Xuansheng 
supported by the National New Drug Innovation Program of China(No.2017ZX09301004);the National Natural Science Foundation of China(No.81873131)。
Icariin, a flavonoid glycoside, is extracted from Epimedium. This study aimed to investigate the vascular protective effects of icariin in type 1 diabetic rats by inhibiting high-mobility group box 1 (HMGB1)-related i...
关键词：ICARIIN Diabetes INFLAMMATION Vascular endothelial dysfunction GPER HMGB1 
Icariin accelerates bone regeneration by inducing osteogenesisangiogenesis coupling in rats with type 1 diabetes mellitus被引量：2
《World Journal of Diabetes》2024年第4期769-782,共14页Sheng Zheng Guan-Yu Hu Jun-Hua Li Jia Zheng Yi-Kai Li 
Supported by the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation,No.GZC20231088;President Foundation of The Third Affiliated Hospital of Southern Medical University,China,No.YP202210.
BACKGROUND Icariin(ICA),a natural flavonoid compound monomer,has multiple pharmacological activities.However,its effect on bone defect in the context of type 1 diabetes mellitus(T1DM)has not yet been examined.AIM To e...
关键词：ICARIIN Osteogenesis-angiogenesis coupling Type 1 diabetes mellitus Bone defect Bone regeneration 
Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis
《Asian Pacific Journal of Tropical Biomedicine》2024年第3期106-114,I0002-I0005,共13页Wei Luo Yi Lu Jun-Hua Deng Peng Liu Yan Huang Wan-Xi Liu Chun-Li Huang 
supported by Affiliated Hospital of Youjiang Medical University for Nationalities(No.Y20212615).
Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on ce...
关键词：Viral myocarditis CVB3 TLR4 Ferroptosis ICARIIN 
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