OSTEOSARCOMA

作品数：365被引量：713H指数：12
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相关领域：医药卫生生物学更多>>
相关作者：李新志陈安民戴闽于小龙林波更多>>
相关机构：华中科技大学广州军区广州总医院上海交通大学附属第六人民医院中南大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma:A novel gene fusion model report and mechanism research
《Genes & Diseases》2025年第3期7-10,共4页Qing Pan Wenbo Yang Fuhua Huang Wei Wu Zengwu Shao Zhicai Zhang 
supported by the National Natural Science Foundation of China(No.82072979).
Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common ...
关键词：AUTOPHAGY mesenchymal malignant tumor fusion mode drug resistance ewsr psmc fusion gene gene alterationgene fusion OSTEOSARCOMA genetic changes 
Research progress on cancer-associated fibroblasts in osteosarcoma
《Oncology Research》2025年第5期1091-1103,共13页LIWEN FENG YUTING CHEN WENYI JIN 
supported by the National Natural Science Foundation of China(grant number 81773285);Beijing Chao-Yang Hospital Golden Seeds Foundation(grant number CYJZ202341).
Osteosarcoma(OS)is a prevalent primary bone malignancy with limited treatment options.Therefore,it is imperative to investigate and understand the mechanisms underlying OS pathogenesis.Cancer-associated fibroblasts(CA...
关键词：Osteosarcoma(OS) Cancer-associated fibroblasts(CAFs) Tumor microenvironment(TME) Bone tumor 
SIK2 promotes malignant features of human osteosarcoma via up-regulating MMP2 andβ-catenin expression
《Genes & Diseases》2025年第2期83-85,共3页Yutong Wang Yulan Yao Sen Kou Shanshan Wang Juntao Song Siqi Yang Hongwei Wang Yunliang Wang 
Osteosarcoma is a primary malignant bone tumor that commonly occurs in children and adolescents.It is highly malignant and prone to metastasis,with a very poor prognosis.There is currently no effective treatment for t...
关键词：MALIGNANT OSTEOSARCOMA METASTASIS 
TanshinoneⅡA Facilitates Chemosensitivity of Osteosarcoma Cells to Cisplatin via Activation of p38 MAPK Pathway
《Chinese Journal of Integrative Medicine》2025年第4期326-335,共10页XIE Da-ming LI Zhi-yun REN Bing-kai GONG Rui YANG Dong HUANG Sheng 
Supported by the Jiangxi Provincial Natural Science Foundation(No.20224ACB206009)。
Objective:To examine the mechanism of action of tanshinoneⅡA(TanⅡA)in promoting chemosensitization of osteosarcoma cells to cisplatin(DDP).Methods:The effects of different concentrations of TanⅡA(0–80μmol/L)and D...
关键词：OSTEOSARCOMA CISPLATIN tanshinone II A P38 MAPK Chinese medicine 
Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation
《National Science Review》2025年第3期363-378,共16页Shunyi Lu Yuqi Yang Zhuorun Song Jie Cao Zhihui Han Linfu Chen Yunfei He Jiayi Wang Yun Teng Zengli Zhang Jun Zou Jun Ge Huilin Yang Liang Cheng 
suppor ted by the National Key Re-search and Development Program of China(2022YFB3804600);the National Natural Science Foundation of China(52472288,82172506 and 82030068);the Collaborative Innovation Center of Suzhou Nano Science and Technology,the Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Science and Technology Development Fund,the Macao SAR(0118/2023/RIA2,0064/2024/AMJ and 0016/2024/RIA1);the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project);the Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,the Jiangsu Funding Program for Excellent Postdoctoral Talent(2024ZB491);the China Postdoctoral Science Foundation(2024M752333);the Natural Science Foundation BoXi Cultivation Program Project of the First Affiliated Hospital of Soochow University(BXQN2023013).
Osteosarcoma(OS),a highly aggressive bone tumor,presents significant challenges in terms of effective treatment.We identified that cellular autophagy was impaired within OS by comparing clinical OS samples through bio...
关键词：OSTEOSARCOMA metal nanoplatform MnSx H2 S gas therapy AUTOPHAGY IMMUNOTHERAPY 
ZiyuglycosideⅡsuppressed the progression of osteosarcoma by coordinating estrogen-related receptor gamma and p53 signaling pathway
《Chinese Journal of Natural Medicines》2025年第3期354-367,共14页Hang Du Dongjin Wu Tianyu Zhang Ying Zhong Kaiyi Wu Xin Guo Lisong Sheng Nana Huang Chunzheng Gao Rong Sun 
supported by the National Key Research and Development Program of China(No.2022YFC3502100);the National Natural Science Foundation of China(No.82274197);the Cutting Edge Development Fund of Advanced Medical Research Institute Municipal Science and(No.GYY2023QY01);the Technology Project of Jinan City(No.202228099).
Osteosarcoma(OS)is the most prevalent primary malignant bone tumor affecting children and adolescents.Despite ongoing research efforts,the 5-year survival rate has remained stagnant for many years,highlighting the cri...
关键词：ZiyuglycosideⅡ OSTEOSARCOMA Cell cycle arrest P53 Estrogen-related receptor gamma 
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune
《Protein & Cell》2025年第2期121-135,共15页Mei-Mei Zhao Ting-Ting Ren Jing-Kang Wang Lu Yao Ting-Ting Liu Ji-Chao Zhang Yang Liu Lan Yuan Dan Liu Jiu-Hui Xu Peng-Fei Tu Xiao-Dong Tang Ke-Wu Zeng 
financially supported by National Natural Sciences Foundation of China(82325050);National Key R&D Program of China(2022YFC3501601);Beijing Municipal Natural Science Foundation(7232273);Jinan New 20 Policies for Higher Education Funding(202228048);Natural Science Foundation of Shandong Province(Joint Foundation for Innovation and Development)(ZR2022LZY021)。
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum(ER)dynamics.However,the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptos...
关键词：PYROPTOSIS ER membrane antitumor immune OSTEOSARCOMA chemical degrader reticulon-4(RTN4) 
Novel Feature Extractor Framework in Conjunction with Supervised Three Class-XGBoost Algorithm for Osteosarcoma Detection from Whole Slide Medical Histopathology Images
《Computers, Materials & Continua》2025年第2期3337-3353,共17页Tanzila Saba Muhammad Mujahid Shaha Al-Otaibi Noor Ayesha Amjad Rehman Khan 
funded by PrincessNourah bintAbdulrahmanUniversity Researchers Supporting Project number(PNURSP2024R136),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
Osteosarcomas are malignant neoplasms derived from undifferentiated osteogenic mesenchymal cells. It causes severe and permanent damage to human tissue and has a high mortality rate. The condition has the capacity to ...
关键词：Medical image processing deep learning healthcare image classification HISTOPATHOLOGY 
Transforming osteosarcoma care:from historical milestones to precision medicine advances
《Science Bulletin》2025年第3期290-294,共5页Jichuan Wang David S.Geller Luyang Sun Xiaodong Tang 
supported by the National Natural Science Foundation of China(82103223);Peking University People’s Hospital Scientific Research Development Funds(RDX2022-01);Peking University Clinical Scientist Training Program(BMU2024PYJH026);Clinical Medicine Plus X-Young Scholars Project,Peking University,the Fundamental Research Funds for the Central Universities(PKU2024LCXQ027);Beijing Physician Scientist Training Project(BJPSTP-2024-10);National Institutes of Health(R01CA255643).
Osteosarcoma(OS),one of the earliest recognized cancers in humans,is a rare yet significant malignant bone tumor,diagnosed in 2-6 cases per million annually[1].It predominantly affects adolescents and young adults,wit...
关键词：OSTEOSARCOMA diagnosis annually 
Osteoimmunology in bone malignancies:a symphony with evil
《Journal of the National Cancer Center》2024年第4期354-368,共15页Churui Song Tie Tong Biqi Dai Yue Zhu Elina Chen Min Zhang Weijie Zhang 
supported by the Fundamental Research Funds for the Zhejiang Provin-cial Universities(grant number:2023QZJH60);the Science Fund Pro-gram for Distinguished Young Scholars from the National Natural Science Foundation of China(grant number:588020-X42306/041);the startup fund from the Life Sciences Institute of Zhejiang University to W.Z.
Bone marrow is pivotal for normal hematopoiesis and immune responses,yet it is often compromised by malig-nancies.The bone microenvironment(BME),composed of bone and immune cells,maintains skeletal integrity and blood...
关键词：Bone metastasis OSTEOSARCOMA OSTEOIMMUNOLOGY Bone microenvironment IMMUNOTHERAPIES 
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