Osteoimmunology in bone malignancies:a symphony with evil  

作　　者：Churui Song Tie Tong Biqi Dai Yue Zhu Elina Chen Min Zhang Weijie Zhang 

机构地区：[1]Department of Breast Surgery and Oncology,Cancer Institute,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China [2]Life Sciences Institute,Zhejiang University,Hangzhou,China [3]College of Natural Sciences,University of Texas at Austin,110 Inner Campus Drive,Austin,USA [4]Zhejiang Provincial Key Laboratory of Pancreatic Disease,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China [5]Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology,Life Sciences Institute,and Department of Orthopaedic Surgery,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China

出　　处：《Journal of the National Cancer Center》2024年第4期354-368,共15页癌症科学进展（英文）

基　　金：supported by the Fundamental Research Funds for the Zhejiang Provin-cial Universities(grant number:2023QZJH60);the Science Fund Pro-gram for Distinguished Young Scholars from the National Natural Science Foundation of China(grant number:588020-X42306/041);the startup fund from the Life Sciences Institute of Zhejiang University to W.Z.

摘　　要：Bone marrow is pivotal for normal hematopoiesis and immune responses,yet it is often compromised by malig-nancies.The bone microenvironment(BME),composed of bone and immune cells,maintains skeletal integrity and blood production.The emergence of primary or metastatic tumors in the skeletal system results in severe complications and contributes significantly to cancer-related mortality.These tumors set offa series of interac-tions among cancer,bone,and immune cells,and disrupt the BME locally or distantly.However,the drivers,participants,and underlying molecules of these interactions are not fully understood.This review explores the crosstalk between bone metabolism and immune responses,synthesizing current knowledge on the intersection of cancer and osteoimmune biology.It outlines how bone marrow immune cells can either facilitate or hinder tumor progression by interacting with bone cells and pinpoints the molecules responsible for immunosuppression within bone tumors.Moreover,it discusses how primary tumors remotely alter the BME,leading to systemic immune suppression in cancer patients.This knowledge provides critical rationales for emerging immunotherapies in the treatment of bone-related tumors.Taken together,by summarizing the intricate relationship between tumor cells and the BME,this review aims to deepen the understanding of the diversity,complexity,and dynamics at play during bone tumor progression.Ultimately,it highlights the potential of targeting bone-tumor interactions to correct aberrant immune functions,thereby inhibiting tumor growth and metastasis.

关 键 词：Bone metastasis OSTEOSARCOMA OSTEOIMMUNOLOGY Bone microenvironment IMMUNOTHERAPIES 

分 类 号：R73[医药卫生—肿瘤]