OSTEOIMMUNOLOGY

作品数：16被引量：54H指数：4
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Osteoimmunology in bone malignancies:a symphony with evil
《Journal of the National Cancer Center》2024年第4期354-368,共15页Churui Song Tie Tong Biqi Dai Yue Zhu Elina Chen Min Zhang Weijie Zhang 
supported by the Fundamental Research Funds for the Zhejiang Provin-cial Universities(grant number:2023QZJH60);the Science Fund Pro-gram for Distinguished Young Scholars from the National Natural Science Foundation of China(grant number:588020-X42306/041);the startup fund from the Life Sciences Institute of Zhejiang University to W.Z.
Bone marrow is pivotal for normal hematopoiesis and immune responses,yet it is often compromised by malig-nancies.The bone microenvironment(BME),composed of bone and immune cells,maintains skeletal integrity and blood...
关键词：Bone metastasis OSTEOSARCOMA OSTEOIMMUNOLOGY Bone microenvironment IMMUNOTHERAPIES 
Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1
《Regenerative Biomaterials》2024年第3期134-147,共14页Caiyao Hou Yujue Zhang Zhaoyong Lv Yurun Luan Jun Li Chunxiu Meng Kun Liu Xin Luo Liyu Chen Fengzhen Liu 
the Science Foundation of Shandong Province of China(Grant Nos ZR2021MH026,ZR2022MH075,ZR2020MH100);Shandong Province Medical and Health Science and Technology Development Plan(2018WS426);Liaocheng Key Research and Development Plan of Shandong Province of China(Grant Nos 2022YDSF16,2022YDSF21,2023YD28,2023YD34).
In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication network.Macrophages play a central role in mediating immune osteogenesis,exosomes derived from them have osteog...
关键词：MACROPHAGE EXOSOMES OSTEOGENESIS OSTEOIMMUNOLOGY 
The effects of matrix stiffness on immune cells in bone biology
《Mechanobiology in Medicine》2024年第2期48-54,共7页Ting Jiang Meng-Ting Zheng Ruo-Mei Li Ning-Juan Ouyang 
supported by the National Natural Science Foundation of China,China(82101047);the Fundamental Research Program funding of the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine,China(JYZZ138).
Bone and immune cells typically inhabit the same microenvironment and engage in mutual interactions to collectively execute the functions of the“osteoimmune system.”Establishing a harmonized and enduring osteoimmune...
关键词：Immune cells STIFFNESS Bone regeneration OSTEOIMMUNOLOGY 
Conformationally regulated“nanozyme-like”cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration被引量：2
《Bioactive Materials》2024年第4期64-79,共16页Shusen Bao Dongmei Yu Zhen Tang Hao Wu Hao Zhang Ning Wang Yichao Liu Hai Huang Chaozong Liu Xiaokang Li Zheng Guo 
supported by grants from the National Key Research and Development Program of China(grant number 2017YFC1104900);the National Natural Science Foundation of China(No.82372124,51871239,and 51771227);the support from the Incubation Program of China Army Medical Science and Technology Youth Training Program(No.17QNP021);the Everest Program of Air Force Military Medical University(No.2020ZFC002)。
Given post-operative aseptic loosening in orthopedic disease treatment,osteointegration occurs at the bone-implant interface as a holistic process,including immunoregulation(e.g.,macrophage polarization),angiogenesis ...
关键词：“Nanozyme-like”cerium oxide Durable redox activation Free radical scavenging Osteoimmunology modulation Vascularized osseointegration 
Osteoimmunology research in rheumatoid arthritis:From single-cell omics approach
《Chinese Medical Journal》2023年第14期1642-1652,共11页Nan Hu Jing Wang Bomiao Ju Yuanyuan Li Ping Fan Xinxin Jin Xiaomin Kang Shufang Wu 
Cellular immune responses as well as generalized and periarticular bone loss are the key pathogenic features of rheumatoid arthritis(RA).Under the pathological conditions of RA,dysregulated inflammation and immune pro...
关键词：Rheumatoid arthritis OSTEOIMMUNOLOGY Single-cell omics Single-cell RNA sequencing scATAC-seq 
Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis被引量：2
《Bioactive Materials》2023年第4期404-422,共19页Jia Li Congrui Zhao Yangbo Xu Lu Song Yanqi Chen Yuzi Xu Yang Ma Siyuan Wang Antian Xu Fuming He 
The study was supported by grants from the National Natural Science Foundation of China(No.82271026);the Key Research and Development Program of Science and Technology Department of Zhejiang Province(No.2019C03081).
Osseointegration seems to be a foreign body reaction equilibrium due to the complicated interactions between the immune and skeletal systems.The heterogeneity of the osteoimmune microenvironment in the osseointegratio...
关键词：OSTEOIMMUNOLOGY NEUTROPHIL Implant OSSEOINTEGRATION Single-cell transcriptomics 
The Role of T Lymphocytes in Bone Remodeling
《Open Journal of Orthopedics》2023年第4期131-146,共16页Jaymes L. Fuller Renee E. Samuel Jason J. Abraham Dina Gad Dana M. Padilla Jessica A. Cottrell 
Bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain bone function. Bone remodeling involves the synchronized differentiation and activity of bone-r...
关键词：OSTEOIMMUNOLOGY Bone Homeostasis Fracture T Cells B Cells OSTEOBLASTS OSTEOCLASTS CHONDROCYTES 
Degradation particles derived from high-purity magnesium inhibit osteogenic differentiation through regulation of macrophage polarization被引量：2
《Journal of Materials Science & Technology》2023年第8期113-119,共7页Yu Sun Han Yu Hongzhou Peng Xinbao Kang Zhaoxiang Peng Xieping Dong Wenhui Wang Yang Song Xiaonong Zhang 
This work was financially supported by the Natural Science Foundation of China(No.82160436);the Science and Technol-ogy Commission of Shanghai Municipality(No.19441905600);the“Science and Technology Innovation 2025Major Special Project of Ningbo(No.2019B10064);the Shanghai Jiao Tong Univer-sity Interdisciplinary(Biomedical Engineering)Research Fund(No.ZH2018ZDA09);China Postdoctoral Science Foundation(No.2021M702090).
Magnesium(Mg)and its alloys have great potential as orthopedic implant candidates,which could release various bioactive substances during degradation.Degradation particles(DPs)are one of the degradation products,but t...
关键词：MAGNESIUM Degradation particles Macrophage PHAGOCYTOSIS OSTEOIMMUNOLOGY 
Engineered extracellular vesicles:Regulating the crosstalk between the skeleton and immune system被引量：2
《Engineered Regeneration》2022年第3期270-282,共13页Wei-Wei Yu Qian-Qian Wan Yu Wei Yu-Tao Li Qi-Hong Li Tao Ye Ke-Hui Xu Jing-Han Song Chen Lei Mei-Chen Wan Kai Jiao Franklin R Tay Li-Na Niu 
supported by grant 2019KB01 from the State Key Laboratory of Military Stomatology,China,grant 81870805 from the National Nature Science Foundation of China,grant 2020TD-033 from the Shaanxi Key Scientific and Technological Innovation Team and by Innovative research team of high-level local universities in shanghai,Oral and maxillofacial regeneration and functional restoration.
Osteoimmunology has gained momentum in recent years,focusing on the crosstalk between the skeleton and the immune system.Extracellular vesicles(EVs)are nanoscale vesicles that are potential candidates for cell-free ti...
关键词：Bone defect CROSSTALK Engineered extracellular vesicles Immune regulation OSTEOIMMUNOLOGY 
Hydroxyapatite composited PEEK with 3D porous surface enhances osteoblast differentiation through mediating NO by macrophage被引量：4
《Regenerative Biomaterials》2022年第1期107-118,共12页Xingdan Liu Liping Ouyang Lan Chen Yuqin Qiao Xiaohan Ma Guohua Xu Xuanyong Liu 
support from the National Natural Science Foundation of China(U21A20100,81772363,32000938);Science and Technology Commission of Shanghai Municipality,China(20ZR1465000);High-end Entrepreneurial and Innovative Teams of Ningbo High-level Talents Project(2018A-09-C);Shenzhen Science and Technology Funding(JCYJ20210324120009026);S&T Innovation 2025 Major Special Program of Ningbo(2018B10040)are acknowledged.
The adverse immune response mediated by macrophages is one of the main factors that are prone to lead poor osseointegration of polyetheretherketone(PEEK)implants in clinic.Hence,endowing PEEK with immunomodulatory abi...
关键词：POLYETHERETHERKETONE three-dimensional porous HYDROXYAPATITE OSTEOIMMUNOLOGY nitric oxide 
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