OSTEOCLASTS

作品数：85被引量：354H指数：10
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相关作者：梁念慈刘晓青吴铁崔燎林路生更多>>
相关机构：广东医学院第二军医大学北京市耳鼻咽喉科研究所浙江大学医学院附属第二医院更多>>
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Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice
《Genes & Diseases》2025年第1期281-297,共17页Liying Shan Xiaoxia Liao Xiaoli Yang Endong Zhu Hairui Yuan Jie Zhou Xiaoxia Li Baoli Wang 
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
关键词：Mechanistictargetof rapamycincomplex1 Naked cuticle homolog 2 OSTEOBLAST OSTEOCLAST Receptoractivatorof nuclearfactorkB ligand WNT/Β-CATENIN 
DEC1 deficiency protects against bone loss induced by ovariectomy by inhibiting inflammation被引量：1
《Journal of Biomedical Research》2024年第6期613-627,共15页Lan Lin Zhiyi Qiang Kaiao Chen Ying Huo Wei Liu Jian Yang 
supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937 to J.Y.);the Special Foundation for Clinical Science and Technology of Jiangsu Province(Grant No.JX10114120).
Studies have shown that differentiated embryo-chondrocyte expressed gene 1(DEC1)promotes osteoblast osteogenesis.To investigate the role of DEC1 in postmenopausal osteoporosis,we used the two genotypes of mice(Dec1+/+...
关键词：DEC1 postmenopausal osteoporosis ESTROGEN OSTEOBLASTS OSTEOCLASTS 
Beyond resorption:osteoclasts as drivers of bone formation
《Cell Regeneration》2024年第1期125-149,共25页Qianfeng Xiang Lei Li Wei Ji Debby Gawlitta X Frank Walboomers Jeroen J.J.P.van den Beucken 
China Scholarship Council(File No.202206270002).
Emerging evidence illustrates that osteoclasts(OCs)play diverse roles beyond bone resorption,contributing signifi-cantly to bone formation and regeneration.Despite this,OCs remain mysterious cells,with aspects of thei...
关键词：OSTEOCLAST Osteoclatogenesis Osteoclast characterization Angiogenesis regulation Bone formation Bone regeneration 
Inflammation-Targeting Fullerene Nanoparticles Dually Inhibit Macrophage and Osteoclast Differentiation for Mitigating Rheumatoid Arthritis
《CCS Chemistry》2024年第9期2275-2288,共14页Lei Liu Xue Li Zhanfeng Wu Libin Yang Jiawei Huo Shaojian Tang Xinran Cao Yuan Xu Xiaodan Liao Hedong Qi Jie Li Jingchao Liu Jianxin Tian Rui Wen Chunru Wang Chunli Bai 
supported by the National Natural Science Foundation of China(grant no.52272048);the Beijing Natural Science Foundation(grant no.2222090);the Ministry of Science and Technology of China(grant no.2022YFA1205900),the Key Research Program of the Chinese Academy of Sciences(grant no.QYKJZD-SSW-SLH01);Natural Science Foundation of Shandong Province(grant no.ZR2020QB016).
In rheumatoid arthritis(RA),the presence of substantial inflammatory macrophages and osteoclasts in joints is known to contribute to the progression of articular inflammation and bone destruction.Herein,we develop a s...
关键词：fullerene targeting inflammation rheumatoid arthritis sialic acid MACROPHAGES OSTEOCLASTS 
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling被引量：1
《Bone Research》2024年第3期555-570,共16页Hanwen Li Yingchuang Tang Zixiang Liu Kangwu Chen Kai Zhang Sihan Hu Chun Pan Huilin Yang Bin Li Hao Chen 
supported by National Natural Science Foundation of China (82172468,82372436 and 32301416);Natural Science Foundation of Jiangsu Province (BK20211326);Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009)。
Degenerated endplate appears with cheese-like morphology and sensory innervation,contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However,the origin and...
关键词：DEGENERATION CARTILAGE INTERVERTEBRAL 
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
《Bone Research》2024年第3期571-581,共11页Hideyuki Kobayashi M.Alaa Terkawi Masahiro Ota Tomoka Hasegawa Tomomaya Yamamoto Tomohiro Shimizu Dai Sato Ryo Fujita Toshifumi Murakami Norio Amizuka Norimasa Iwasaki Masahiko Takahata 
supported by a Grant-in-Aid for Exploratory Research from the Ministry of Education,Culture,Sports,Science,and Technology of Japan 17H04309 (MT);the Mitsubishi foundation。
DNAX-associated protein 12 kD size(DAP12)is a dominant immunoreceptor tyrosine-based activation motif(ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis.Although several DAP1...
关键词：REMODELING OSTEOCLAST stimulating 
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
《Bone Research》2024年第3期720-733,共14页Daizhao Deng Xianming Liu Wenlan Huang Sirui Yuan Genming Liu Shanshan Ai Yijie Fu Haokun Xu Xinyi Zhang Shihai Li Song Xu Xiaochun Bai Yue Zhang 
supported by Grant Nos.31872799,82070906 and 31701033 from the National Natural Science Foundation of China;Grant Nos.2020A1515011189 from Guangdong Basic and Applied Basic Research Foundation of China。
Osteoclast is critical in skeletal development and fracture healing,yet the impact and underlying mechanisms of their metabolic state on these processes remain unclear.Here,by using osteoclast-specific small GTPase Rh...
关键词：HEALING SKELETAL CATHEPSIN 
A review:the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts
《Journal of Future Foods》2024年第3期183-192,共10页Mengjie Ren Adel F.Ahmed Meng Li Menghan Li Zhiruo Yan Jinmei Wang 
supported by the College students’innovation Project of Henan University(20221020006).
Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk,leading to the osteoporosis.More and more evidences proved that plant-derived polysaccharides could have a rema...
关键词：Osteoporosis Plant-derived polysaccharides Osteogenesis promotion Osteoclasts inhibition 
Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期513-528,共16页Miao CHU Guangdong CHEN Kai CHEN Pengfei ZHU Zhen WANG Zhonglai QIAN Huaqiang TAO Yaozeng XU Dechun GENG 
supported by the National Natural Science Foundation of China(Nos.82272157,82072425,and 82072498);the Natural Science Foundation of Jiangsu Province(No.BE2021650);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,the Program of Suzhou Health Commission(Nos.GSWS2022002 and GSWS2020121);the Jiangsu Medical Research Project(No.ZD2022014);the National and Local Engineering Laboratory of New Functional Polymer Materials(No.SDGC2205);the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(No.LCZX202003),China.
Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the elderly.Osteoclast activation plays a crucial role in the occurrence of subchondral bone loss in early OA.However,the specific mechanism of osteoclast...
关键词：OSTEOCLAST Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) CARNOSOL 
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
《Bone Research》2024年第2期407-420,共14页Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee 
supported by grants from the National Research Foundation of Korea(RS-2023-00217798 and 2021R1A2C3003675 to S.Y.L.);by the Korea Basic Science Institute National Research Facilities&Equipment Center grant(2019R1A6C1010020).M.K.was supported in part by scholarship from Ewha Womans University.
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border.However,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts...
关键词：OSTEOCLAST inhibited traffic 
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