ESTROGEN

作品数：430被引量：1137H指数：15
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相关领域：医药卫生更多>>
相关作者：潘俊丽曲婷岳利民喻琳麟张金虎更多>>
相关机构：首都医科大学第四军医大学西京医院陕西师范大学复旦大学更多>>
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High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期269-285,共17页Quanmin KANG Fang LE Xiayuan XU Lifang CHEN Shi ZHENG Lijun LOU Nan JIANG Ruimin ZHAO Yuanyuan ZHOU Juan SHEN Minhao HU Ning WANG Qiongxiao HUANG Fan JIN 
supported by the National Key Research and Development Program of China(No.2018YFC1004900);the National Natural Science Foundation of China(No.82101799);the Health Science and Technology Foundation of Zhejiang Province of China(No.2022KY186).
Given that ovarian stimulation is vital for assisted reproductive technology(ART)and results in elevated serum estrogen levels,exploring the impact of elevated estrogen exposure on oocytes and embryos is necessary.We ...
关键词：Ovarian stimulation Histone methylation Assisted reproductive technology(ART) 
4-Nitrophenol at environmentally relevant concentrations mediates reproductive toxicity in Caenorhabditis elegans via metabolic disorders-induced estrogen signaling pathway
《Journal of Environmental Sciences》2025年第1期244-258,共15页Jia Wang Jiechen Yin Danhong Peng Xiaoqian Zhang Zhouhong Shi Weixi Li Yingchi Shi Mingjun Sun Nan Jiang Beijing Cheng Xingchen Meng Ran Liu 
supported by the National Natural Science Foundation of China(Nos.82173479 and 81872579);Jiangsu Provincial Maternal and Child Health Scientific Research Project(No.F201907).
4-Nitrophenol(4-NP),as a toxic and refractory pollutant,has generated significant concern due to its adverse effects.However,the potential toxic effects andmechanism remained unclear.In this study,the reproduction,dev...
关键词：4-NITROPHENOL Caenorhabditis elegans Metabolomics Pathway analysis 
Development of NIR Responsive Upconversion Nanosensor for Turn-on Detection of 4-Nonylphenol
《发光学报》2025年第1期140-155,共16页HUANG Sili XU Kuncheng YE Yiwen WEN Hongli CHEN Rihui SONG Wei CHEN Wei ABDUR Raheem Aleem 
国家自然科学基金(22075052);广东省基础与应用基础研究基金(2023A1515012988);广东省省级科技计划项目(2022A0505020005);江苏省教育厅项目(EFP10120240023)。
4-Nonylphenol(NP)is a kind of estrogen belonging to the endocrine disrupter,widely used in various agricultural and industrial goods.However,extensive use of NP with direct release to environment poses high risks to b...
关键词：Er^(3+)/Yb^(3+)/Nd^(3+) upconversion nanoparticles Förster resonance energy transfer ESTROGEN DETECTION 
Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe
《Science China Chemistry》2025年第1期360-368,共9页Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng 
supported by the National Natural Science Foundation of China(22338005,22208045,2192580,U23A20489);the Liaoning Binhai Laboratory(LBLB-2023-03);the Fundamental Research Funds for the Central Universities(DUT22LAB60);the Zhejiang Provincial Natural Science Foundation(TGY24B060002);the Ningbo Natural Science Foundation(2022J012,2023S115)。
Endoplasmic reticulum(ER)viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF).Herein,we report the first ER-targeting viscosity-responsive near-infrared(NIR)fluorescent probe HBT-PP for investig...
关键词：NIR fluorescent probe ER viscosity hepatic fibrosis gender difference ESTROGEN 
Inhibition of Cancer Cell Growth by Baicalein via ESR1 Based on Molecular Dynamics Simulations
《Proceedings of Anticancer Research》2024年第6期150-156,共7页Chao Kang Mengke Wang Yongsong Zhang 
This study investigates the mechanism by which baicalin inhibits cancer cell growth through estrogen receptor 1 (ESR1) using molecular dynamics simulations. The results show that baicalin primarily binds to the ligand...
关键词：BAICALIN ESR1 Molecular dynamics simulation Cancer cell growth Estrogen signaling pathway 
DEC1 deficiency protects against bone loss induced by ovariectomy by inhibiting inflammation被引量：1
《Journal of Biomedical Research》2024年第6期613-627,共15页Lan Lin Zhiyi Qiang Kaiao Chen Ying Huo Wei Liu Jian Yang 
supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937 to J.Y.);the Special Foundation for Clinical Science and Technology of Jiangsu Province(Grant No.JX10114120).
Studies have shown that differentiated embryo-chondrocyte expressed gene 1(DEC1)promotes osteoblast osteogenesis.To investigate the role of DEC1 in postmenopausal osteoporosis,we used the two genotypes of mice(Dec1+/+...
关键词：DEC1 postmenopausal osteoporosis ESTROGEN OSTEOBLASTS OSTEOCLASTS 
Exogenous estrogen partially rescues progesterone deficiency and autophagosome enlargement in Mcoln1^(-/-)mouse model with lysosomal storage disorder
《Reproductive and Developmental Medicine》2024年第4期197-205,共9页Zidao Wang Yuehuan Li Christian L.Andersen Ahmed E.El Zowalaty Jonathan M.Hancock Taylor E.Martin Elizabeth W.Howerth Suvitha Viswanathan Haeyeun Byun Xiaoqin Ye 
the Offfce of the Vice President for Research,Interdisciplinary Toxicology Program,and Department of Physiology and Pharmacology at the University of Georgia,and the National Institutes of Health(grants NIH R01HD065939[co-funded by ORWH and NICHD],R03HD097384,and R03 HD100652 to X.Y.)for ffnancial support;Serum P4 and E2 levels were determined at The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core,which is supported by the Eunice Kennedy Shriver NICHD/NIH(NCTRI)Grant P50-HD28934.
Objective:FemaleMcoln1^(-/-)mice exhibit progressive progesterone(P4)deficiency,luteal cell degeneration,and premature embryo implantation failure at 5 months old.We attempted to rescue embryo implantation in non-virg...
关键词：TRPML1/Mcoln1 Corpus luteum PROGESTERONE ESTROGEN Heat shock protein 60 Collagen IV Transmission electron microscopy AUTOPHAGOSOME Lipid droplet 
Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
《Food Science and Human Wellness》2024年第6期3301-3310,共10页Qian Chen Haiqin Chen Jianxin Zhao Wei Chen Gang Wang 
funded by the National Natural Science Foundation of China(32021005);the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP51501);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province.
The decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women.Increasing estradiol levels is key to preventing disease in men...
关键词：ESTRADIOL AROMATASE Gut microbiota Amino acids 
Intricate roles of estrogen and estrogen receptors in digestive system cancers:a systematic review被引量：1
《Cancer Biology & Medicine》2024年第10期898-915,共18页Xiaoning Gan Guanqi Dai Yonghao Li Lin Xu Guolong Liu 
supported by grants from the Project of Scientific and Technologic Bureau of Guangzhou City(Grant No.202201010165);the Key Project of Scientific and Technologic Bureau of Guangzhou City(Grant No.202201020335).
Gender disparities are evident across different types of digestive system cancers,which are typically characterized by a lower incidence and mortality rate in females compared to males.This finding suggests a potentia...
关键词：ESTROGEN estrogen receptor CANCER digestive system cancers gender disparity 
Structural and functional evidence that GPR30 is not a direct estrogen receptor
《Cell Research》2024年第7期530-533,共4页Heng Liu Shimeng Guo Antao Dai Peiyu Xu Xin Li Sijie Huang Xinheng He Kai Wu Xinyue Zhang Dehua Yang Xin Xie H.Eric Xu 
the National Natural Science Foundation of China(82121005 to X.X.,H.E.X.and D.Y.,32130022 to H.E.X.,82330113 to X.X.,82273985 to D.Y.,82304579 to S.G.);CAS Strategic Priority Research Program(XDB37030103 to H.E.X.);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to H.E.X.);Shanghai Municipal Science and Technology Major Project(H.E.X.);the Lingang Laboratory(LG-GG-202204-01 to H.E.X.);the National Key R&D Program of China(2022YFC2703105 to H.E.X.);Shanghai Municipality Science and Technology Development Fund(21JC1401600 to D.Y.);Program of Shanghai Academic/Technology Research Leader(23XD1400900 to D.Y.).
ear Editor,Estrogen is a pivotal hormone in human physiology,orchestrating a wide range of biological processes ranging from reproductive functions to cardiovascular health and bone integrity.1 The orphan receptor GPR...
关键词：GPR30 ESTROGEN CARDIOVASCULAR 
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