BAICALIN

作品数：119被引量：813H指数：16
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相关领域：医药卫生更多>>
相关作者：钟大放靳士晓陈笑艳袁海龙邢杰更多>>
相关机构：沈阳药科大学中国科学院解放军第302医院中山大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金湖北省自然科学基金更多>>
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Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages
《Acta Pharmacologica Sinica》2025年第2期430-447,共18页Yi-ping You Liang Yan Hua-yu Ke Ya-ping Li Zi-jian Shi Zhi-ya Zhou Hai-yan Yang Tao Yuan Ying-qing Gan Na Lu Li-hui Xu Bo Hu Dong-yun Ou-Yang Qing-bing Zha Xian-hui He 
supported by the grants from the National Natural Science Foundation of China(82274167,81773965,and 81873064);the Science and Technology Project of Heyuan,China(Social Development and Rural Science No.2023008);the Project of Guangdong Administration of Traditional Chinese Medicine(20232177).
PANoptosis is an emerging form of regulated cell death(RCD)characterized by simultaneous activation of pyroptotic,apoptotic,and necroptotic signaling that not only participates in pathologies of inflammatory diseases ...
关键词：MACROPHAGES PANoptosis BAICALIN mitochondrial Z-DNA ZBP1 hemophagocytic lymphohistiocytosis 
Inhibition of Cancer Cell Growth by Baicalein via ESR1 Based on Molecular Dynamics Simulations
《Proceedings of Anticancer Research》2024年第6期150-156,共7页Chao Kang Mengke Wang Yongsong Zhang 
This study investigates the mechanism by which baicalin inhibits cancer cell growth through estrogen receptor 1 (ESR1) using molecular dynamics simulations. The results show that baicalin primarily binds to the ligand...
关键词：BAICALIN ESR1 Molecular dynamics simulation Cancer cell growth Estrogen signaling pathway 
A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
《Journal of Integrative Medicine》2024年第6期621-636,共16页Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang Yong-sheng Jin 
supported by National Natural Science Foundation of China(No.81573585);the Innovative Practice of Undergraduate Project of Naval Medical University(No.FH2021104)。
Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and ...
关键词：BAICALIN BAICALEIN Antiviral effects Influenza virus FLAVIVIRUS Hepatitis B virus Mechanism 
Baicalin Prevents Colon Cancer by Suppressing CDKN2A Protein Expression
《Chinese Journal of Integrative Medicine》2024年第11期1007-1017,共11页LI Gang-gang CHU Xiu-feng XING Ya-min XUE Xia Ihtisham Bukhari LIANG Xin-feng XU Ji-xuan MI Yang ZHENG Peng-yuan 
Supported by Key Projects of Discipline Construction in Zhengzhou University(No.XKZDJC202001);Science and Technology Research and Development of Henan Province(No.242102311279)。
Objective:To observe the therapeutic effects and underlying mechanism of baicalin against colon cancer.Methods:The effects of baicalin on the proliferation and growth of colon cancer cells MC38 and CT26.WT were observ...
关键词：colon cancer BAICALIN CDKN2A network pharmacology cell cycle APOPTOSIS 
A multifunctional baicalin-coordinated borate ions/bacterial cellulose composite hydrogel for efficient treatment of chronic wounds
《Medicine in Novel Technology and Devices》2024年第3期70-80,共11页Wenxin Zhang Shubi Zhao Siwen Wu Tianran Song Qifeng Guan Junwei Xu Jingxi Wang Ping Li Yubo Fan 
supported by funds from National Natural Science Foundation of China(NSFC)Research Grants(52072015,62273019,U20A20390,11827803);the 111 Project(B13003).
Microbial infection,poor vascular regeneration and abnormal inflammation often impede the smooth repair of skin wounds,and these problems need to be effectively addressed.Baicalin is a natural flavonoid compound with ...
关键词：BAICALIN Borate ions Composite hydrogel Antibacterial activity ANTI-INFLAMMATORY Wound healing 
Populational change of CD4^(+)CD25^(+)Treg cells is responsible for the synergistic effect of the combination of RAMP2 with baicalin in treating recurrent spontaneous abortion mouse models
《Traditional Medicine Research》2024年第8期59-66,共8页Cong Chen Zhuo-Lan Li Jing-Tian Guo Wen-Yao Xue Wei Guo 
the National Natural Science Foundation of China(81973221);National Natural Science Foundation for Young Scientists of China(81603647);the Women and Children Health Talent Project of Jiangsu Province(FRC201785);the Chinese Clinical Medicine Innovation Center of Obstetrics,Gynecology,and Reproduction in Jiangsu Province(ZX202102);the Women and Children Health Science Foundation of Jiangsu Province(F202206).
Background: The absence of a safe and effective therapy for recurrent spontaneous abortion due to a maternofetal failure in immunological tolerance remains an intractable clinical obstacle for surgeons. Recently, trad...
关键词：recurrent spontaneous abortion Atractylodes macrocephala Koidz. Scutellaria baicalensis Georgi CBA/J×DBA/2 regulatory T cells 
Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor
《Journal of Pharmaceutical Analysis》2024年第7期1047-1062,共16页Qi Jia Yinyin Zhou Li Song Ximeng Shi Xuan Jiang Ruizhi Tao Aiyun Wang Yuanyuan Wu Zhonghong Wei Yinan Zhang Xiaoman Li Yin Lu 
supported by the Matching Grant of National Natural Science Foundation of China from Nanjing University of Chinese Medicine(Grant Nos.:NZY81903857,and NZY81703765);the National Natural Science Foundation of China(Grant No.:21877062);the Opening Project of Chinese Materia Medica FirstClass Discipline of Nanjing University of Chinese Medicine(Grant No.:2020YLXK020);Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant Nos.:SJCX21_0707,KYCX21_1772,and KYCX22_2039).
Recent studies have shown that stress can substantially facilitate breast cancer metastasis,which can be reduced by nonselective β1/β2-adrenergic receptor(β1/β2-AR)blocker.However,several side effects were identif...
关键词：BAICALIN Chronic stress Breast cancer metastasis β2-adrenergic receptor Epithelial-mesenchymal transition 
Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第4期634-644,共11页Shuangxiu Wan Linzheng Wang Zhili Hao Lin Zhu Xiaoxia Mao Hongquan Li Panpan Sun Wei Yin Kuohai Fan Hailong Zhang Beibei Li Wansen Nie Zongjie Li Na Sun 
supported by the grants from the National Key Research and Development Program(No.2022YFD1801101);the special fund for Science and Technology Innovation Teams of Shanxi Province(No.202204051001021);Key Research and Development Plan of Shanxi Province(No.202102140601019);Basic Research Plan of Shanxi Province(No.20210302124408);Shanxi“1331 Project”(Nos.20211331-13 and 20211331-16);Heze University Doctor Foundation Grant(No.XY22BS36).
The deoxynivalenol(DON)-contaminated feeds can impair chicken gut barrier function,disturb the balance of the intestinal microbiota,decrease chicken growth performance and cause major economic loss.With the aim of inv...
关键词：BAICALIN BROILER immune homeostasis gut barrier gut microbiota 
Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens被引量：2
《Journal of Animal Science and Biotechnology》2024年第2期779-794,共16页Mingkun Gao Chaoyong Liao Jianyang Fu Zhonghua Ning Zengpeng Lv Yuming Guo 
funded by National Key R&D Program of China(2022YFD1300403,2021YFD1300404);China Agriculture Research System program(CARS-40,CARS-41-G11);Beijing Natural Science Foundation(6222036).
Background Baicalin and probiotic cocktails are promising feed additives with broad application prospects.While probiotic cocktails are known to enhance intestinal health,the potential synergistic impact of combining ...
关键词：BAICALIN Gut health Ileal microbiota Probiotic cocktails Synergistic effects 
Attenuation of the Activation of NLRP3 Inflammasome in Fibroblast Like Synoviocytes of Rheumatoid Arthritis by Baicalin through Regulating the Let-7i-3p/PI3K/Akt/NF-κB Signaling Axis
《Medicinal Plant》2024年第2期69-73,76,共6页Wei ZHANG Li WANG Yuxin YANG Rui MA Li WANG Ling HUANG Qiaofeng WAN 
Supported by the National Natural Science Foundation of China(82360802):the Natural Science Foundation of Ningxia Province,China(2022AAC 03152).
[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the...
关键词：BAICALIN Rheumatoid arthritis Human fibroblast like synoviocytes of rheumatoid arthritis NLRP3 inflammasome miRNA Dual-luciferase 
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