BAICALEIN

作品数：71被引量：386H指数：11
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相关领域：医药卫生更多>>
相关作者：张黎胡燕华王琼李惠勉杨琳更多>>
相关机构：中国药科大学华中科技大学郑州大学第二附属医院北京大学更多>>
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相关基金：国家自然科学基金河南省科技攻关计划国家杰出青年科学基金广东省自然科学基金更多>>
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Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade
《Acta Pharmacologica Sinica》2025年第2期366-379,共14页Li-xia Du Xin-yi Gao Xue-qi Ren Ya-yue Yang Yang-yang Ding Ao Xu Xiao-yu Wang Yu-xin Zhang Shi Shu Yu-fang Yang Wen-li Mi Zhi-fei Wang 
supported by the National Natural Science Foundation of China(82204830);the Shanghai Sailing Program(21YF1447500).
Chronic itch is a maladaptive and debilitating symptom in patients with allergic contact dermatitis(ACD),adversely affecting their quality of life.There is a lack of effective treatments for ACD-associated uncontrolla...
关键词：BAICALEIN chronic itch ASTROCYTES STAT3 LCN2 
A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
《Journal of Integrative Medicine》2024年第6期621-636,共16页Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang Yong-sheng Jin 
supported by National Natural Science Foundation of China(No.81573585);the Innovative Practice of Undergraduate Project of Naval Medical University(No.FH2021104)。
Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and ...
关键词：BAICALIN BAICALEIN Antiviral effects Influenza virus FLAVIVIRUS Hepatitis B virus Mechanism 
Inhibition of Cancer Cell Growth by Baicalein via ESR1 Based on Molecular Dynamics Simulations
《Proceedings of Anticancer Research》2024年第6期150-156,共7页Chao Kang Mengke Wang Yongsong Zhang 
This study investigates the mechanism by which baicalin inhibits cancer cell growth through estrogen receptor 1 (ESR1) using molecular dynamics simulations. The results show that baicalin primarily binds to the ligand...
关键词：BAICALIN ESR1 Molecular dynamics simulation Cancer cell growth Estrogen signaling pathway 
High sensitivity detection of baicalein by N,S co⁃doped carbon dots and their application in biofluids
《无机化学学报》2024年第10期2009-2020,共12页FAN Junmei LIU Wei ZHU Ruitao QIN Chenxi LEI Xiaoling WANG Haotian WANG Jiao HAN Hongfei 
国家自然科学基金(No.22302144);山西省基础研究计划青年项目(No.20210302124217,202103021223332);大学生创新创业训练项目(No.CXCY2435);蛋白质基功能材料实验室(No.2022P010)资助。
In this work,p⁃phenylenediamine and L⁃cysteine were used as raw materials,and water⁃soluble N,S co⁃doped carbon dots(N,S⁃CDs)with excellent performance were prepared through a one⁃step solvothermal method.The morpholo...
关键词：N S⁃carbon dots solvothermal method BAICALEIN fluorescent sensor 
Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A
《Virologica Sinica》2024年第4期685-693,共9页Yanyan Dong Enze Shao Siwei Li Ruiqi Wang Dan Wang Lixin Wang Hong Yang Yingxia He Tian Luan Yang Chen Yao Wang Lexun Lin Yan Wang Zhaohua Zhong Wenran Zhao 
supported by the National Natural Science Foundation of China(82172247 and 81971920 to WZ,82072278 to ZZ,and 82202493 to LL,82302502 to Yao Wang);Natural Science Foundation of Heilongjiang Province of China(YQ2023H003);China Postdoctoral Science Foundation(2021M693818);Heilongjiang Postdoctoral Fund,Heilongjiang Province of China(LBH-Z21023).
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy.Group B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which prim...
关键词：BAICALEIN Coxsackievirus B(CVB) MYOCARDITIS 2A protease CASPASE-1 
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis被引量：1
《Acta Pharmacologica Sinica》2024年第8期1715-1726,共12页Jian-qin Lai Le-le Zhao Chao Hong Qiu-ming Zou Jin-xuan Su Si-jia Li Xiao-feng Zhou Zi-sheng Li Bo Deng Jie Cao Qi Qi 
supported by National Natural Science Foundation of China(82173236,81973341);Guangdong Basic and Applied Basic Research Foundation(2024A1515013108);the program of Guangdong Provincial Clinical Research Center for Digestive Diseases(2020B1111170004);Medical Joint Fund of Jinan University(YXJC2022002);Guangzhou High-level Key Clinical Specialty Construction Project(No.9);the Project of Key Medical Discipline in Guangzhou(2021-2023);Guangzhou Science and Technology Planning Project(202206080008);2023 Guangzhou digestive disease high-quality integrated treatment system construction project.
Colorectal cancer(CRC)is a prevalent form of gastrointestinal malignancy with challenges in chemotherapy resistance and side effects.Effective and low toxic drugs for CRC treatment are urgently needed.Ferroptosis is a...
关键词：colorectal cancer BAICALEIN ferroptosis JAK2/STAT3 GPX4 liproxstatin-1 
Baicalein:A potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
《Journal of Pharmaceutical Analysis》2024年第8期1189-1204,共16页Na Liu Xin Cui Wenhui Yan Tingli Guo Zhuanzhuan Wang Xiaotong Wei Yuzhuo Sun Jieyun Liu Cheng Xian Weina Ma Lina Chen 
funded by the Fundamental Research Funds for the Central Universities(Grant No.:xzd012022099);Natural Science Basic Research Program of Shaanxi(Grant Nos.:2023-JC-ZD-47,and 2023-JC-QN-0921);Research Project of Shaanxi Administration of Traditional Chinese Medicine(Project No.:SZY-KJCYC-2023-008);Research Project of Guangxi Administration of Traditional Chinese Medicine(Project No.:GXZYJ20230711);Basic&Clinical Sciences Integration Innovation Project of Xi'an Jiaotong University(Project No.:YXJLRH2022018).
There is increasing evidence that the activation of glucagon-like peptide-1 receptor(GLP-1R)can be used as a therapeutic intervention for cognitive disorders.Here,we have screened GLP-1R targeted compounds from Scutel...
关键词：GLP-1R agonist DIABETES Cognitive disorder MITOPHAGY Cell membrane chromatography 
Pre‑hatch thermal manipulation of embryos and post‑hatch baicalein supplementation mitigated heat stress in broiler chickens被引量：1
《Journal of Animal Science and Biotechnology》2024年第3期1071-1085,共15页Sadid Al Amaz Ajay Chaudhary Prem Lal Mahato Rajesh Jha Birendra Mishra 
The research was funded by a USDA Multistate(2052R)grant from the CTAHR University of Hawaii at Manoa to B.M.
Background High environmental temperatures induce heat stress in broiler chickens,affecting their health and pro-duction performance.Several dietary,managerial,and genetics strategies have been tested with some succes...
关键词：BAICALEIN Growth performance Gut microbiota Heat stress Thermal manipulation 
The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation
《Journal of Clinical and Translational Hepatology》2024年第5期496-504,共9页Ziyang Zeng Yuhao Lei Chunyong Yang Xianfeng Wu Liang Zhang Zhiyong Yang Lin Chen Xiaobo Wang Karine Belguise Yujie Li Bin Yi 
supported by the National Science Foundation of China(No.82070630 to BY,No.82100658 to YL);Science Foundation of Chongqing(cstc2019jcyj-msxmX0667 to ZZ);National Key R&D Program of China(No.2018YFC0116702 to BY).
Background and Aims:Hepatopulmonary syndrome(HPS)is characterized by arterial oxygenation defects due to pulmonary vascular dilation in liver disease.To date,liver transplantation remains the only effective treatment ...
关键词：BAICALEIN Hepatopulmonary syndrome Common bile duct ligation ANGIOGENESIS Glucose metabolism Liver fibrosis GLYCOLYSIS 
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
《Acta Pharmacologica Sinica》2024年第3期480-489,共10页De-wen Kong Li-da Du Run-zhe Liu Tian-yi Yuan Shou-bao Wang Yue-hua Wang Yang Lu Lian-hua Fang Guan-hua Du 
supported by the Beijing Natural Science Foundation(7232258);the CAMS Innovation Fund for Medical Sciences(Nos.2021-/2M-1-005,2022-/2M-JB-010).
Dopaminergic neurons in the substantia nigra(SN)expressing SUR1/Kir6.2 type ATP-sensitive potassium channels(K-ATP)are more vulnerable to rotenone or metabolic stress,which may be an important reason for the selective...
关键词：Parkinson’s disease BAICALEIN SH-SY5Y cells K-ATP channels SUR1 subunit ROTENONE 
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