ROTENONE

作品数：79被引量：323H指数：10
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相关领域：医药卫生更多>>
相关作者：柯国秀杨亚萍陆杰孙圣刚张颖冬更多>>
相关机构：苏州大学南京医科大学南京师范大学苏州大学附属第二医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金湖北省自然科学基金更多>>
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C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice
《Asian Pacific Journal of Tropical Biomedicine》2024年第7期279-287,共9页Hritik Rathod Ritu M.Soni Jigna S.Shah 
Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease.Methods:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily...
关键词：Parkinson’s disease C-PHYCOCYANIN Alphasynuclein BDNF Oxidative stress ROTENONE 
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
《Acta Pharmacologica Sinica》2024年第3期480-489,共10页De-wen Kong Li-da Du Run-zhe Liu Tian-yi Yuan Shou-bao Wang Yue-hua Wang Yang Lu Lian-hua Fang Guan-hua Du 
supported by the Beijing Natural Science Foundation(7232258);the CAMS Innovation Fund for Medical Sciences(Nos.2021-/2M-1-005,2022-/2M-JB-010).
Dopaminergic neurons in the substantia nigra(SN)expressing SUR1/Kir6.2 type ATP-sensitive potassium channels(K-ATP)are more vulnerable to rotenone or metabolic stress,which may be an important reason for the selective...
关键词：Parkinson’s disease BAICALEIN SH-SY5Y cells K-ATP channels SUR1 subunit ROTENONE 
Spatiotemporal visualization of the synthesis and accumulation of rotenone in Derris elliptica roots using mass spectrometry imaging
《Advanced Agrochem》2023年第4期340-348,共9页Ping Li Yingying Chen Qingrong Xie Yizhu Xu Zhen Li Yuan Li Zhibin Yin Xinhai Zhu Hanhong Xu Xinzhou Wu 
the financial support from the Spring Sunshine Programme by the Ministry of Education of China(No.HZKY20220113);Natural Science Foundation of Guangdong Province(No.2023A1515030241);the Youth Talent Support Programme of Guangdong Provincial Association for Science and Technology(No.SKXRC202315);Young Talent Support Project of Guangzhou Association for Science and Technology(No.QT20220101031);supported by the Science and Technology Planning Project of Guangzhou(No.SL2022A04J00958).
The discovery of novel botanical pesticides as a preferred alternative to synthetic pesticides is regarded as an environmentally friendly strategy,yet it remains a great challenge due to limited insights into the synt...
关键词：ROTENONE Derris elliptica root Mass spectrometry imaging Spatial distribution Temporal accumulation 
The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?被引量：4
《Neural Regeneration Research》2023年第8期1652-1656,共5页Ana Flávia F.Ferreira Luiz Roberto G.Britto 
funded by Coordination for the Improvement of Higher Education Personnel (CAPES,Brazil-Finance Code 001,to LRB);the S?o Paulo Research Foundation(FAPESP,Brazil,project#2018/07366-4);The National Council for Scientific and Technological Development (CNPq,Brazil,project#303006/2018-8,to LRB);a PhD fellowship from FAPESP under Grant Agreement No 2020/02109-3。
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating m...
关键词：1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine(MPTP) 1-methyl-4-phenylpyridinium(MPP+) 6-HYDROXYDOPAMINE AG490 CLOTRIMAZOLE flufenamic acid N-(p-amylcinnamoyl)anthranilic acid Parkinson's disease poly-ADPR polymerase type 1(PARP1) ROTENONE PARAQUAT transient receptor potential melastatin 2(TRPM2) 
Protective effect of lycopene on Parkinson's disease cell model based on endoplasmic reticulum stress
《Journal of Hainan Medical University》2023年第14期15-21,共7页BAO Bo CHAI Xing-xing DENG Zi-liang LIU Lu-lu ZHU Shao-ping LI Li-li 
Science and Technology Program of Guangdong Province(No.2013B060300038);Scientific Research Foundation of Guangdong Medical University(No.GDMUM2019029)。
Objective:To evaluate the effect of lycopene on Parkinson's disease cell model and its possible mechanism.Methods:The SH-SY5Y cells were treated with 0.5μmol/L rotenone for 24 h to establish Parkinson's disease cell ...
关键词：LYCOPENE ROTENONE Parkinson's disease Endoplasmic reticulum stress 
Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect被引量：4
《Neural Regeneration Research》2023年第6期1371-1377,共7页Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich 
supported by the Department of Anesthesiology and Critical Care,Medical Center-University of Freiburg,Germany;funded by the Baden-Wuerttemberg Ministry of Science,Research and Art and the University of Freiburg in the funding program Open Access Publishing
The noble gas argon has the potential to protect neuronal cells from cell death.So far,this effect has been studied in treatment after acute damage.Preconditioning using argon has not yet been investigated.In this stu...
关键词：apoptosis inflammation INTERLEUKIN-8 neuroprotection ROTENONE SH-SY5Y Toll-like receptor 2 Toll-like receptor 4 
Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model被引量：1
《Acta Pharmacologica Sinica》2023年第4期752-765,共14页Yeojin Bang Yoonjung Kwon Mihyang Kim Soung Hee Moon Kiwon Jung Hyun Jin Choi 
supported by the GRRC program of Gyeonggi Province,Korea(GRRCCHA2017-A01,Validity and Safety Evaluation of Regional Specialized Resources);the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science,ICT&Future Planning,Korea(NRF-2016R1C1B1015991,NRF-2019R1H1A1080255,and NRF2021R1A2C1013180).
Protein aggregation and the abnormal accumulation of aggregates are considered as common mechanisms of neurodegeneration such as Parkinson’s disease(PD).Ursolic acid(UA),a natural pentacyclic triterpenoid compound,ha...
关键词：AUTOPHAGY JNK Parkinson’s disease ROTENONE SH-SY5Y cells ursolic acid 
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease被引量：9
《Neural Regeneration Research》2023年第1期194-199,共6页Chun-Bo Hu Hui Jiang Yin Yang Guo-Hua Wang Qiu-Hong Ji Zhong-Zheng Jia Li-Hua Shen Qian-Qian Luo 
funded by the National Natural Science Foundation of China, No. 81873924 (to QQL), No. 82171190 (to GHW);Nantong Science and Technology Project of China, No. MS22021010 (to LHS);High-level Innovation and Entrepreneurship Talents Introduction Program of Jiangsu Province of China (to QQL)
DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke.NBP has sho...
关键词：cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron ROTENONE transferrin receptor 
Angiotensin-(1–7)reducesα-synuclein aggregation by enhancing autophagic activity in Parkinson's disease被引量：2
《Neural Regeneration Research》2022年第5期1138-1145,共8页Qing Gao Rui Chen Liang Wu Qing Huang Xi-Xi Wang You-Yong Tian Ying-Dong Zhang 
supported by the National Natural Science Foundation of China,No.81801263(to QG)。
Abnormal accumulation ofα-synuclein contributes to the formation of Lewy bodies in the substantia nigra,which is considered the typical pathological hallmark of Parkinson's disease.Recent research indicates that angi...
关键词：Α-SYNUCLEIN apoptosis AUTOPHAGY dopaminergic neuron Lewy bodies neurodegenerative diseases Parkinson's disease renin-angiotensin system ROTENONE substantia nigra 
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson’s disease models被引量：2
《Acta Pharmacologica Sinica》2021年第12期1991-2003,共13页Wen-li Dong Jia-hong Zhong Yun-qing Chen Jin-feng Xie Yun-yun Qin Jiang-ping Xu Ning-bo Cai Meng-fan Li Lu Liu Hai-tao Wang 
supported by Guangdong Basic and Applied Basic Research Foundation(2021A1515011133);Science and Technology Program of Guangzhou(No.202002030494);National Natural Science Foundation of China(Nos.81773698 and 81974501);Key-Area Research and Development Program of Guangdong Province(No.2018B030334001);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_16R37).
We have previously shown that roflupram(ROF)protects against MPP^(+)-induced neuronal damage in models of Parkinson’s disease(PD).Since impaired degradation of α-synuclein(α-syn)is one of the key factors that lead ...
关键词：Parkinson’s disease Α-SYNUCLEIN SIRT1 ROTENONE roflupram LYSOSOME Sirtuin 1 pepstatin A 
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