C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice  

作　　者：Hritik Rathod Ritu M.Soni Jigna S.Shah 

机构地区：[1]Department of Pharmacology,Institute of Pharmacy Nirma University,Ahmedabad,Gujarat,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第7期279-287,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease.Methods:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 days.Behavioral studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral deficits.Glutathione and malondialdehyde were determined in both serum and striatal tissue.Molecular proteins(AKT,AMPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using ELISA.Histopathological analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the striatum.Results:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein levels.It also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone group.Additionally,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by C-phycocyanin.Conclusions:C-phycocyanin might have potential neuroprotective effects against Parkinson’s disease.Further studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关 键 词：Parkinson’s disease C-PHYCOCYANIN Alphasynuclein BDNF Oxidative stress ROTENONE 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R285[医药卫生—临床医学]