A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin  

作　　者：Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang Yong-sheng Jin 

机构地区：[1]School of Basic Medicine,Naval Medical University,Shanghai 200433,China [2]Faculty of Traditional Chinese Medicine,Naval Medical University,Shanghai 200433,China [3]School of Pharmacy,Naval Medical University,Shanghai 200433,China

出　　处：《Journal of Integrative Medicine》2024年第6期621-636,共16页结合医学学报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.81573585);the Innovative Practice of Undergraduate Project of Naval Medical University(No.FH2021104)。

摘　　要：Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and its glucuronide derivative baicalin are two main components extracted from Scutellaria baicalensis Georgi.They have proven to be effective against a broad range of viruses by directly killing virus particles,protecting infected cells,and targeting viral antigens on their surface,among other mechanisms.As natural products,they both possess the advantage of lower toxicity,enhanced therapeutic efficacy,and even antagonistic effects against drug-resistant viral strains.Baicalein and baicalin exhibit promising potential as potent pharmacophore scaffolds,demonstrating their antiviral properties.However,to date,no review on the antiviral effects of baicalein and baicalin has been published.This review summarizes the recent research progress on antiviral effects of baicalein and baicalin against various types of viruses both in vitro and in vivo with a focus on the dosages and underlying mechanisms.The aim is to provide a basis for the rational development and utilization of baicalein and baicalin,as well as to promote antiviral drug research.

关 键 词：BAICALIN BAICALEIN Antiviral effects Influenza virus FLAVIVIRUS Hepatitis B virus Mechanism 

分 类 号：R285[医药卫生—中药学]