The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation  

作　　者：Ziyang Zeng Yuhao Lei Chunyong Yang Xianfeng Wu Liang Zhang Zhiyong Yang Lin Chen Xiaobo Wang Karine Belguise Yujie Li Bin Yi 

机构地区：[1]Department of Anesthesiology,Southwest Hospital,Third Military Medical University,Chongqing,China [2]Department of Anesthesiology,Chongqing Traditional Chinese Medicine Hospital,Chongqing,China [3]MCD,Center de Biologie Intégrative,Universitéde Toulouse,CNRS,UPS,Toulouse,France

出　　处：《Journal of Clinical and Translational Hepatology》2024年第5期496-504,共9页临床与转化肝病杂志（英文版）

基　　金：supported by the National Science Foundation of China(No.82070630 to BY,No.82100658 to YL);Science Foundation of Chongqing(cstc2019jcyj-msxmX0667 to ZZ);National Key R&D Program of China(No.2018YFC0116702 to BY).

摘　　要：Background and Aims:Hepatopulmonary syndrome(HPS)is characterized by arterial oxygenation defects due to pulmonary vascular dilation in liver disease.To date,liver transplantation remains the only effective treatment for HPS.This study aimed to explore the preventative role of baicalein in HPS development.Methods:Sixty male rats were randomly assigned to three groups:sham,common bile duct ligation(CBDL),and baicalein,receiving intraperitoneal injections of baicalein(40 mg·kg^(-1)·d^(-1),diluted in saline)for 21 days.Survival rate,liver and kidney function,and bile acid metabolism levels were evaluated.Liver and lung angiogenesis and hepatic glycogen staining were assessed,and the expression of relevant proteins was evaluated by immunohistochemistry.Results:Baicalein improved survival rates and hypoxemia in rats post-CBDL,reducing angiogenic protein levels and enhancing glucose homeostasis.Compared to the untreated group,baicalein suppressed the expression of vascular endothelial growth factor,placental growth factors,matrix metalloprotease 9 and C-X-C motif chemokine 2,and it increased the expression of glycemic regulatory proteins,including dipeptidyl peptidase-4,sirtuin 1,peroxisome proliferatoractivated receptor gamma co-activator 1α,and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3.Conclusion:Baicalein significantly improves hepatic function and hypoxia in HPS rats by attenuating pathological angiogenesis in the liver and lungs,showing promise as a treatment for HPS.

关 键 词：BAICALEIN Hepatopulmonary syndrome Common bile duct ligation ANGIOGENESIS Glucose metabolism Liver fibrosis GLYCOLYSIS 

分 类 号：R575[医药卫生—消化系统]