MITOPHAGY

作品数：219被引量：899H指数：14
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相关领域：医药卫生生物学更多>>
相关作者：陈良郑俊张英才杨扬更多>>
相关机构：哈尔滨医科大学附属第二医院哈尔滨医科大学中国医学科学院复旦大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials
《Neural Regeneration Research》2025年第9期2437-2453,共17页Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu 
supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC);the STI2030-Major Projects,No.2022ZD0211800(to YX);Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ...
关键词：autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control MITOPHAGY spinal cord injury subarachnoid hemorrhage traumatic brain injury 
Luteolin,a common flavone in vegetables,acts as a hormetin possessing neurotrophic function:signaling mediated by inducing mitochondrial stress
《Food Science and Human Wellness》2025年第2期569-580,共12页Alex Xiong Gao Tracy Chenxi Xia Maggie Suisui Guo Gary Kawing Yuen Kevin Qiyun Wu Tina Tingxia Dong Karl Wah-Keung Tsim 
supported by Hong Kong RGC-GFC 16100921;Hong Kong RGC Theme-based Research Scheme(T13-605/18-W);Hong Kong Innovation Technology Fund(PRP/076/20FXITCPD/17-9,MHP/004/21);PD18SC01 and HMRF18SC06;HMRF20SC07,AFD20SC01;Shenzhen Science and Technology Innovation Committee(ZDSYS201707281432317)。
This study aims to uncover the hormetic process of luteolin,a common dietary flavone,in neuronal cells through its role in inducing mitochondrial stress.In rat pheochromocytoma PC12 cells,luteolin at low concentration...
关键词：Flavonoids HORMESIS Mitochondrial membrane potential Autophagy MITOPHAGY 
TFE3-mediated neuroprotection:Clearance of aggregatedα-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease
《Genes & Diseases》2025年第2期368-382,共15页Xin He Mulan Chen Yepeng Fan Bin Wu Zhifang Dong 
supported by the National Natural Science Foundation of China (No.32371030,82071395);the CQMU Program for Youth Innovation in Future Medicine (Chongqing,China) (No.wo044);the Natural Science Foundation of Chongqing,China (No.CSTB2022NSCQBHX0022,CSTB2024NSCQ-LZX0008).
Parkinson's disease(PD)is a neurodegenerative disorder characterized by fibrillar neuronal inclusions containing aggregatedα-synuclein(α-Syn).While the pathology of PD is multi-faceted,the aggregation ofα-Syn and m...
关键词：Α-SYNUCLEIN Autophagy Mitochondrial biogenesis MITOPHAGY Parkinson's disease TFE3 
Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke
《Journal of Intensive Medicine》2025年第1期89-99,共11页Ran Meng Zhengzhong Sun Ruxue Chil Yan Gu Yuxiang Zhang Jiaxing Wang 
supported by the 2020 Special Tasks for Military Health and Epidemic Prevention and Protection(grant number Hou Wei Han[2021]No.208);Hospital Project(grant number 2016ZD-008).
Background:The roles of the Pink1/Parkin pathway and mitophagy in lung injury during heat stroke remain unclear.In this study,we investigated the role of Pink1/Parkin-mediated mitophagy in acute lung injury(ALI)in rat...
关键词：Exertional heat stroke Acutelung injury MITOPHAGY PINK1 PARKIN 
Resveratrol promotes mitophagy via the MALAT1/miR-143-3p/RRM2 axis and suppresses cancer progression in hepatocellular carcinoma
《Journal of Integrative Medicine》2025年第1期79-92,共14页Chun-yan Feng Cheng-song Cai Xiao-qian Shi Zhi-juan Zhang Dan Su Yun-qing Qiu 
supported by the Zhejiang Provincial Science and Technology Department Key Research and Development Plan(No.2020C03046).
Objective Resveratrol(Res)is a promising anticancer drug against hepatocellular carcinoma(HCC),but whether its anti-HCC effects implicate mitophagy remains unclear.Therefore,we aimed to explore the specific role of Re...
关键词：Hepatocellular carcinoma RESVERATROL MITOPHAGY MALAT1 miR-143-3p 
Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability
《Life Metabolism》2025年第1期17-34,共18页Yik-Lam Cho Hayden Weng Siong Tan Jicheng Yang Basil Zheng Mian Kuah Nicole Si Ying Lim Naiyang Fu Boon-Huat Bay Shuo-Chien Ling Han-Ming Shen 
supported by grants to S.C.L.from the Swee Liew-Wadsworth Endowment fund,National University of Singapore(NUS),Ministry of Education(MOE-T2EP30220-0014),Singapore;the National Research Foundation(NRF-ISF003-3221),Singapore;grants to H.M.S.from University of Macao(CPG2023-0032FHS and UM-MYRG2020-00022-FHS);Macao Science and Technology Development Fund(FDCT0078/2020/A2,FDCT0031/2021/A1,FDCT0081/2022/AMJ,and FDCT 0004/2021/AKP);supported by the NUS Graduate School Research Scholarships.
Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the pentose phosphate pathway(PPP)in glycolysis.Glucose metabolism is closely implicated in the regulation of mitophagy,a selective form of autopha...
关键词：G6PD MITOPHAGY PINK1 ROS NADPH PPP 
Mitochondrial dysfunction in the pathogenesis of acute pancreatitis被引量：1
《Hepatobiliary & Pancreatic Diseases International》2025年第1期76-83,共8页Xia Chen Rui Zhong Bing Hu 
supported by a grant from the Fund of Chengdu Medical College (CYZYB22-03)。
The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as...
关键词：Acute pancreatitis AUTOPHAGY Calcium Cell death Inflammation MITOCHONDRIA MITOPHAGY 
A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy
《Chinese Journal of Natural Medicines》2025年第2期214-224,共11页Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou 
supported by the National Natural ScienceFoundation of China (No.82174076);the Construction Project of Liaoning Provincial Key Laboratory,China (No.2022JH13/10200026);the Fundamental Research Funds for the Central Universities (No.N2220002);the 111 Project (No.B16009);the Research Project of Educational Commission of Liaoning Province (No.LJ212410164003)。
Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or mortality.Resveratrol,extracted from Polygonum cuspidatum Sieb.et Zucc.(commonly known as Japanese knotweed),has bee...
关键词：(E)-4-(3 5-dimethoxystyryl)quinoline RESVERATROL Ischemic stroke MITOPHAGY PARKIN 
Electroacupuncture enhances the mitophagy of granulosa cells in premature ovarian insufficiency model mice by inactivating the hippo-yes-associated protein/transcriptional co-activator with postsynaptic density protein,drosophila disc large tumor suppresso
《Journal of Traditional Chinese Medicine》2025年第1期13-21,共9页WU Jiaman TANG Meng LUO Yu ZHU Haimin ZHAO Tianqi MA Fei NING Yan 
Shenzhen Science and Innovation Commission:Investigating the Mechanism of Action of Acupuncture in Regulating the Gut Microbiome to Inhibit Apoptosis of Ovarian Granulosa Cells in Premature Ovarian Insufficiency Mice based on the Rictor/Torepamycin Target Protein c2 Pathway(No.JCYJ20210324130001004);Sanming Project of Medicine in Shenzhen:the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Luo Songping National Famous Chinese Medicine Practitioner Female Reproductive Disorders Prevention and Treatment Team(SZZYSM202311010)。
OBJECTIVE:To investigate the potential mechanism of electroacupuncture(EA)in alleviating premature ovarian insufficiency(POI)and to provide a theoretical basis for EA treatment of POI.METHODS:For this purpose,a POI mi...
关键词：primary ovarian insufficiency acupuncture point CV4(Guanyuan) MITOPHAGY hippo signaling pathway 
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy
《Chinese Journal of Integrative Medicine》2025年第1期19-27,共9页LIU Tian-yi HAO Yu MAO Qin ZHOU Na LIU Meng-hua WU Jun WANG Yi YANG Ming-rui 
Supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A00601 and CI2021B017-09)。
Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages inf...
关键词：Tanreqing Injection influenza virus ANTI-INFLAMMATION MITOPHAGY nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome Chinese medicine 
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