MITOPHAGY

作品数：226被引量：922H指数：14
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相关领域：医药卫生生物学更多>>
相关作者：陈良郑俊张英才杨扬更多>>
相关机构：哈尔滨医科大学附属第二医院哈尔滨医科大学中国医学科学院复旦大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Role of mitophagy in spinal cord ischemia-reperfusion injury
《Neural Regeneration Research》2026年第2期598-611,共14页Yanni Duan Fengguang Yang Yibao Zhang Mingtao Zhang Yujun Shi Yun Lang Hongli Sun Xin Wang Hongyun Jin Xuewen Kang 
supported by Cuiying Scientific and Technological Innovation Program of Second Hospital of Lanzhou University,Nos.CY2023-QN-B18(to YD),2020QN-16(to YZ);the Natural Science Foundation of Gansu Province,No.22JR11RA082(to YZ);Key R&D Plan of Gansu Provincial Department of Science and Technology-Social Development Projects,No.23YFFA0043(to XK).
Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic su...
关键词：BNIP3 BNIP3L/NIX FUNDC1 mechanism MITOCHONDRIA MITOPHAGY modulators PARKIN PINK1 spinal cord ischemia-reperfusion injury 
Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials
《Neural Regeneration Research》2025年第9期2437-2453,共17页Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu 
supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC);the STI2030-Major Projects,No.2022ZD0211800(to YX);Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ...
关键词：autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control MITOPHAGY spinal cord injury subarachnoid hemorrhage traumatic brain injury 
Luteolin,a common flavone in vegetables,acts as a hormetin possessing neurotrophic function:signaling mediated by inducing mitochondrial stress
《Food Science and Human Wellness》2025年第2期569-580,共12页Alex Xiong Gao Tracy Chenxi Xia Maggie Suisui Guo Gary Kawing Yuen Kevin Qiyun Wu Tina Tingxia Dong Karl Wah-Keung Tsim 
supported by Hong Kong RGC-GFC 16100921;Hong Kong RGC Theme-based Research Scheme(T13-605/18-W);Hong Kong Innovation Technology Fund(PRP/076/20FXITCPD/17-9,MHP/004/21);PD18SC01 and HMRF18SC06;HMRF20SC07,AFD20SC01;Shenzhen Science and Technology Innovation Committee(ZDSYS201707281432317)。
This study aims to uncover the hormetic process of luteolin,a common dietary flavone,in neuronal cells through its role in inducing mitochondrial stress.In rat pheochromocytoma PC12 cells,luteolin at low concentration...
关键词：Flavonoids HORMESIS Mitochondrial membrane potential Autophagy MITOPHAGY 
TFE3-mediated neuroprotection:Clearance of aggregatedα-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease
《Genes & Diseases》2025年第2期368-382,共15页Xin He Mulan Chen Yepeng Fan Bin Wu Zhifang Dong 
supported by the National Natural Science Foundation of China (No.32371030,82071395);the CQMU Program for Youth Innovation in Future Medicine (Chongqing,China) (No.wo044);the Natural Science Foundation of Chongqing,China (No.CSTB2022NSCQBHX0022,CSTB2024NSCQ-LZX0008).
Parkinson's disease(PD)is a neurodegenerative disorder characterized by fibrillar neuronal inclusions containing aggregatedα-synuclein(α-Syn).While the pathology of PD is multi-faceted,the aggregation ofα-Syn and m...
关键词：Α-SYNUCLEIN Autophagy Mitochondrial biogenesis MITOPHAGY Parkinson's disease TFE3 
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism
《Research》2025年第1期854-869,共16页Dehuan Wang Jingwei Jiang Mengyue Wang Ke Li Huan Liang Nian'ou Wang Weiwei Liu Miaomiao Wang Siyi Zhou Man Zhang Yang Xiao Xinyu Shen Zeming Li Wang Wu Xia Lin Xiao Xiang Qiaoli Xie Wanqian Liu Xun Zhou Qu Tang Wei Zhou Li Yang Cheng-Ming Chuong Mingxing Lei 
supported by the National Key Research and Development Program of China(2023YFC2508200);the National Natural Science Foundation of China(82373509,82003384,and 82203960);Fundamental Research Funds for the Central Universities(2022CDJYGRH-003 and 2023CDJKYJH066);the Natural Science Foundation of Chongqing(CSTB2023JXJL-YFX0028);Chongqing Talents:Exceptional Young Talents Project(cstc2021ycjh-bgzxm0197);Inheritance and Innovation Team of TCM Treatment of Immune Diseases,Scientific Research Foundation from Chongqing University(02210011044110);Research Horizontal Projects of Chongqing University(H20231432 and H20230936),China;C.-M.C.is supported by a research contract(GR1035751)between USC and CMU and US NIH grant R37 AR060306.
Mitophagy maintains tissue homeostasis by self-eliminating defective mitochondria through autophagy.How mitophagy regulates stem cell activity during hair regeneration remains unclear.Here,we found that mitophagy prom...
关键词：mitochondrial activity glutathione metabolism probetransmission electron microscopyand tissue homeostasis hair regeneration stem cell activity 
《Silver Bullet of Acidification》: Studying Anti-PD Neuroprotective Mechanisms of Transient pH-Decrease
《BIOCELL》2025年第3期451-464,共14页Kristina A.Kritskaya Evgeniya I.Fedotova Alexander D.Nadeev Alexey V.Berezhnov 
supported by the Ministry of Science and Higher Education of the Russian Federation in the Framework of State Assignment of PSCBR RAS 075-00609-24-01(No.1022080100047-5-1.6.4,Neuroprotective drugs of a new generation).
Objective:Activation of mitophagy is a promising option to overcome the mitochondrial malfunction that accompanies many diseases.Herein,we investigate the mechanisms underlying the ability of sodium lactate and pyruva...
关键词：Parkinson’s disease mitochondrial network MITOPHAGY FIBROBLASTS 
Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy
《Research》2025年第1期135-148,共14页Yu-Sheng Shi Tian-Ning Yang Yu-Xiang Wang Xiang-Yu Ma Shuo Liu Yi Zhao Jin-Long Li 
supported by the National Natural Science Foundation of China(no.32172932);Key Program of Natural Science Foundation of Heilongjiang Province of China(no.ZD2021C003);China Agriculture Research System of MOF and MARA(no.CARS-35);Distinguished Professor of Longjiang Scholars Support Project(no.T201908),Heilongjiang Touyan Innovation Team Program.
The accumulation of senescent cells in kidneys is considered to contribute to age-related diseases and organismal aging.Mitochondria are considered a regulator of cell senescence process.Atrazine as a triazine herbici...
关键词：mitochondrial homeostasis cell senescence processatrazine triazine herbicide parkin mediated mitophagy senescent cells ATRAZINE renal tubular epithelial cell senescence MELATONIN 
Zishen Huoxue decoction(ZSHX)alleviates ischemic myocardial injury(MI)via Sirt5-β-tubulin mediated synergistic mechanism of"mitophagy-unfolded protein response"and mitophagy
《Chinese Journal of Natural Medicines》2025年第3期311-321,共11页Xing Chang Siyuan Zhou Yu Huang Jinfeng Liu Yanli Wang Xuanke Guan Qiaomin Wu Zhiming Liu Ruxiu Liu 
supported by the National Natural Science Foundation of China(No.82305204),the Special Project on Academic Inheritance and Communication,China Academy of Chinese Medical Sciences(No.CI2022E012XB);Chinese Academy of Chinese Medical Sciences Doctoral Talents Training Fund(No.2021);the Special Program for Training Outstanding Young Talents of Chinese Academy of Traditional Chinese Medicine(No.ZZ16-YQ-021);the Innovative Cultivation Project of Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences(No.2022s481).
Zishen Huoxue decoction(ZSHX)enhances cardiomyocyte viability following hypoxic stress;however,its upstream therapeutic targets remain unclear.Network pharmacology and RNA sequencing analyses revealed that ZSHX target...
关键词：MITOPHAGY Mitochondrial unfolded protein response Zishen Huoxue decoction Sirtuin 5 Β-TUBULIN Mitochondrial oxidative stress 
Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke
《Journal of Intensive Medicine》2025年第1期89-99,共11页Ran Meng Zhengzhong Sun Ruxue Chil Yan Gu Yuxiang Zhang Jiaxing Wang 
supported by the 2020 Special Tasks for Military Health and Epidemic Prevention and Protection(grant number Hou Wei Han[2021]No.208);Hospital Project(grant number 2016ZD-008).
Background:The roles of the Pink1/Parkin pathway and mitophagy in lung injury during heat stroke remain unclear.In this study,we investigated the role of Pink1/Parkin-mediated mitophagy in acute lung injury(ALI)in rat...
关键词：Exertional heat stroke Acutelung injury MITOPHAGY PINK1 PARKIN 
Resveratrol promotes mitophagy via the MALAT1/miR-143-3p/RRM2 axis and suppresses cancer progression in hepatocellular carcinoma
《Journal of Integrative Medicine》2025年第1期79-92,共14页Chun-yan Feng Cheng-song Cai Xiao-qian Shi Zhi-juan Zhang Dan Su Yun-qing Qiu 
supported by the Zhejiang Provincial Science and Technology Department Key Research and Development Plan(No.2020C03046).
Objective Resveratrol(Res)is a promising anticancer drug against hepatocellular carcinoma(HCC),but whether its anti-HCC effects implicate mitophagy remains unclear.Therefore,we aimed to explore the specific role of Re...
关键词：Hepatocellular carcinoma RESVERATROL MITOPHAGY MALAT1 miR-143-3p 
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