Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials  

作　　者：Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu 

机构地区：[1]Department of Neurology,Nanjing Drum Tower Hospital,Clinical College of Jiangsu University,Nanjing,Jiangsu Province,China [2]Department of Neurology,Nanjing Drum Tower Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Nanjing,Jiangsu Province,China [3]Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China [4]State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing,Jiangsu Province,China [5]Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing,Jiangsu Province,China [6]Nanjing Neurology Medical Center,Nanjing,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2025年第9期2437-2453,共17页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC);the STI2030-Major Projects,No.2022ZD0211800(to YX);Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。

摘　　要：Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关 键 词：autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control MITOPHAGY spinal cord injury subarachnoid hemorrhage traumatic brain injury 

分 类 号：R741[医药卫生—神经病学与精神病学]