MITOCHONDRIA

作品数：984被引量：3942H指数：27
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Role of mitophagy in spinal cord ischemia-reperfusion injury
《Neural Regeneration Research》2026年第2期598-611,共14页Yanni Duan Fengguang Yang Yibao Zhang Mingtao Zhang Yujun Shi Yun Lang Hongli Sun Xin Wang Hongyun Jin Xuewen Kang 
supported by Cuiying Scientific and Technological Innovation Program of Second Hospital of Lanzhou University,Nos.CY2023-QN-B18(to YD),2020QN-16(to YZ);the Natural Science Foundation of Gansu Province,No.22JR11RA082(to YZ);Key R&D Plan of Gansu Provincial Department of Science and Technology-Social Development Projects,No.23YFFA0043(to XK).
Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic su...
关键词：BNIP3 BNIP3L/NIX FUNDC1 mechanism MITOCHONDRIA MITOPHAGY modulators PARKIN PINK1 spinal cord ischemia-reperfusion injury 
Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases
《Neural Regeneration Research》2025年第12期3349-3369,共21页Yichen Peng Li Zhou Yaju Jin Danli Wu Na Chen Chengcai Zhang Hongpeng Liu Chunlan Li Rong Ning Xichen Yang Qiuyue Mao Jiaxin Liu Pengyue Zhang 
supported by Yunnan Province Innovation Team of Prevention and Treatment for Brain Disease with Acupuncture and Tuina,No.202405AS350007;Youth Top Talent Project of 10-thousand Talent Plan in Yunnan Province,No.YNWR-QNBJ-2018-345;the National Natural Science Foundation of China,No.81960731;Joint Special Project of Traditional Chinese Medicine in Science and Technology Department of Yunnan Province,Nos.2019FF002[-008],202001AZ070001-002 and 202001AZ070001-030;Yunnan Province University Innovation Team Projects No.2019YGC04;Yunnan Province Project Education Fund,Nos.2024Y406,2024Y414(all to PZ)。
The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels.Mitochondria-associated endoplasmic reticulum membranes serve as ph...
关键词：Alzheimer’s disease amyotrophic lateral sclerosis Ca^(2+)signaling conduction Huntington’s disease ischemic stroke MAMMALS mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury 
Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome
《Neural Regeneration Research》2025年第9期2587-2588,共2页Laetitia Aubry Timothy Barrett Sovan Sarkar 
supported by LifeArc Philanthropic Fund(P2019-0004);LifeArc Pathfinder Award;along with Wellcome Trust Seed Award(109626/Z/15/Z);FA PESP-UoB Strategic Collaboration Fund;Birmingham Fellowship(to SS);grants from Laboratoire d'Excellence Revive(Investissement d'Avenir;ANR-10-LABX-73);the Region lle-de-France via doctoral school Innovation Therapeutique,du Fondamentalàl'Appliqué(ED569)from Universite Paris-Saclay(to LA);Medical Research Council(MRC)Developmental Pathway Funding Scheme(DPFS)grant(MR/P007732/1)(to TB);supported by the Association Fran?aise contre les Myopathies(AFM-Téléthon)。
Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are o...
关键词：OXIDATIVE CYCLE carboxylic 
Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery
《Neural Regeneration Research》2025年第8期2181-2198,共18页Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao 
supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW);the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...
关键词：delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects 
Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria
《Genes & Diseases》2025年第3期533-549,共17页Jingyi Su Yongdong Pan Fengbo Zhong Yi Zhong Jiaxin Huang Shengnan Liu Kaiyuan Wang Kai Lin Xiangchen Gu Dali Li Qihui Wu Hongquan Geng Yuting Guan Guofeng Xu 
supported by grants from the Science and Technology Commission of Shanghai Municipality of China(No.23Y21900102 to G.X.;23ZR1467900 to Q.W.);Shanghai Rising-Star Program(No.22QA1405900 to Y.G.);the National Key R&D Program of China(No.2022YFC2505400,2022YFC3400203 to Y.G.);the National Natural Science Foundation of China(No.82100773 to Y.G.;82101486,82371426 to Q.W.);the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX1621 to Y.G.);the Ningxia Hui Autonomous Region Key Research and Development Project(China)(No.2022BFH02012 to Q.W.).
Cystinuria is the most common inheritable cause of kidney stone disease,with males exhibiting a higher susceptibility than females.However,the cellular origin and underlying mechanisms of sex differences in cystinuria...
关键词：CYSTINURIA Kidney injury MITOCHONDRIA Sex bias Slc3a1 
NECAB family of neuronal calcium-binding proteins in health and disease
《Neural Regeneration Research》2025年第5期1236-1243,共8页Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner 
supported by the Deutsche Forschungsgemeinschaft (ME1922/14-1) to AM。
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le...
关键词：CALCIUM EF hand MITOCHONDRIA nervous system signal transduction 
Dibutyl phthalate disrupts[Ca^(2+)]_(i),reactive oxygen species,[pH]_(i),protein kinases and mitochondrial activity,impairing sperm function
《Journal of Environmental Sciences》2025年第5期68-78,共11页Seung Hyun Park Myung Chan Gye 
supported by the National Research Foundation of Republic of Korea(NRF)grant funded by the Republic of Korea government(MSIT)(No.2022R1A2C1007831).
To explore the mechanism of sperm dysfunction caused by dibutyl phthalate(DBP),the effects of DBP on intracellular[Ca^(2+)]and[pH],reactive oxygen species(ROS),lipid peroxidation(LPO),mitochondrial permeability transi...
关键词：Dibutyl phthalate Reactive oxygen species(ROS) [Ca^(2+)]_(i) [pH]_(i) MITOCHONDRIA Protein kinases SPERM 
Mechanistic insight on nanomaterial-induced reactive oxygen species formation
《Journal of Environmental Sciences》2025年第5期200-210,共11页Jianzhong Cao Qingchun Wu Xuting Liu Xiangyu Zhu Chunfeng Huang Xinyu Wang Yang Song 
supported by the National Natural Science Foundation of China(No.22176206).
Reactive oxygen species(ROS)are closely related to cell death,proliferation and inflammation.However,excessive ROS levels may exceed the cellular oxidative capacity and cause irreversible damage.Organisms are often in...
关键词：NANOMATERIALS Reactive oxygen species(ROS) TOXICITY MITOCHONDRIA Oxidative stress 
Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology
《Neural Regeneration Research》2025年第5期1407-1408,共2页Daniel Adam Felix Langerscheidt Hans Zempel 
TAU is a neuronal microtubule-associated protein preferentially located in axons.In a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosph...
关键词：ALZHEIMER TAU diseases 
Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells
《World Journal of Gastrointestinal Oncology》2025年第4期442-450,共9页Yan-Xu Hou Wei Ren Qing-Qiang He Li-Yan Huang Tian-Hua Gao Hua Li 
BACKGROUND Colon cancer is one of the most common malignancies worldwide,and chemo-therapy is a widely used strategy in colon cancer clinical therapy.Chemotherapy resistance is the main cause of recurrence and progres...
关键词：TETRAMETHYLPYRAZINE Colon cancer Reactive oxygen species APOPTOSIS Cell proliferation 
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