supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL);5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL);the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...
supported by Guizhou Provincial Basic Research Program(Natural Science)(Qiankeheji-ZK[2021]General 497);Guizhou Health and Wellness Commission Science and Technology Fund Project(2024-247);Guizhou University of Traditional Chinese Medicine Academic Seedling Program(Guizhou Kehe Academic Seedling[2023]-35),The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Institutional Research Grants(GZEYK[2020-34]).
Background:Cadmium(Cd)exposure disrupts bone microstructure and elevates osteoporosis risk,warranting innovative functional food development to alleviate its toxic effects.This study evaluated the protective effects o...
supported by the Deutsche Forschungsgemeinschaft (ME1922/14-1) to AM。
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le...
Supported by Calygene Biotechnology Inc.,No.XT[2016]008@。
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi...
supported by the Natural Science Foundation in Xinjiang Uygur Autonomous Region(Urumqi,China,2023D01F38).
Objective:To observe the effect of Xipayimaizibizi oral liquid(XP)in an overactive bladder(OAB)experimental rat model and to explore its pharmacological mechanisms.Methods:Network pharmacology was used to explore the ...
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeost...
Introduction: During pregnancy, the increased demand for all the nutrients required for the development of the foetus means that the maternal stock of trace elements and minerals may become unbalanced if dietary intak...
supported by the Science and Technology Development Fund,Macao S.A.R(FDCT)(0070/2022/A2,005/2023/SKL,China);the National Natural Science Foundation of China(82173848);the Research Fund of University of Macao(MYRG2020-00053-ICMS,MYRG-GRG2023-00072-ICMS-UMDF,China);the Ministry of Education Frontiers Science Centre for Precision Oncology,University of Macao(SP2023-00001-FSCPO,China).
Human NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavoenzyme expressed at high levels in multiple solid tumors,making it an attractive target for anticancer drugs.Bioactivatable drugs targeting NQO1,such asβ-lapacho...
supported by grants from the Russian Science Foundation(23-44-00054);the National Natural Science Foundation of China(32261133525).
Stromal interaction molecules(STIM)s are Ca^(2+)sensors in internal Ca^(2+)stores of the endoplasmic reticulum.They activate the store-operated Ca^(2+)channels,which are the main source of Ca^(2+)entry in non-excitabl...
BACKGROUND The progression of diabetic kidney disease(DKD)affects the patient’s kidney glomeruli and tubules,whose normal functioning is essential for maintaining normal calcium(Ca)and phosphorus(P)metabolism in the ...