Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state  

作　　者：Elena Ambrosini Angela Lanciotti Maria Stefania Brignone 

机构地区：[1]Department of Neuroscience,Istituto Superiore di Sanità,Rome,Italy

出　　处：《Neural Regeneration Research》2025年第7期2008-2010,共3页中国神经再生研究（英文版）

基　　金：supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL);5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL);the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。

摘　　要：Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关 键 词：alterations MODULATOR MAINTAIN 

分 类 号：R741[医药卫生—神经病学与精神病学]