supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant[RGPIN 250139]to A.O.S.E.
Arsenic,a naturally occurring toxic element,manifests in various chemical forms and is widespread in the environment.Exposure to arsenic is a well-established risk factor for an elevated incidence of various cancers a...
financially supported by the Ministry of Science and Technology of the People’s Republic of China (2022YFE0110200);the National Natural Science Foundation of China (52025035, 52273157, and 52073279);the Department of Science and Technology of Jilin Province (20240305041YY and 20230508102RC);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2022224)。
β-Lapachone (β-Lap) is a promising orthonaphthoquinone drug for cancer treatment and has been inclinical trials. Its application is constrained by the low aqueoussolubility, and severe side effects. Even prodrug des...