CRYPTOTANSHINONE

作品数：22被引量：70H指数：5
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A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway
《Acta Pharmaceutica Sinica B》2025年第2期991-1006,共16页Ying Hou Bingling Zhong Lin Zhao Heng Wang Yanyan Zhu Xianzhe Wang Haoyi Zheng Jie Yu Guokai Liu Xin Wang Jose M.Martin-Garcia Xiuping Chen 
supported by the Science and Technology Development Fund,Macao S.A.R(FDCT)(0070/2022/A2,005/2023/SKL,China);the National Natural Science Foundation of China(82173848);the Research Fund of University of Macao(MYRG2020-00053-ICMS,MYRG-GRG2023-00072-ICMS-UMDF,China);the Ministry of Education Frontiers Science Centre for Precision Oncology,University of Macao(SP2023-00001-FSCPO,China).
Human NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavoenzyme expressed at high levels in multiple solid tumors,making it an attractive target for anticancer drugs.Bioactivatable drugs targeting NQO1,such asβ-lapacho...
关键词：NQO1 CRYPTOTANSHINONE Iron Ferroptosis NADþdepletion CALCIUM Targeted therapy Cancer 
Carrier-free cryptotanshinone-peptide conjugates self-assembled nanoparticles:An efficient and low-risk strategy for acne vulgaris
《Asian Journal of Pharmaceutical Sciences》2024年第4期85-102,共18页Quanfu Zeng Hongkai Chen Zhuxian Wang Yinglin Guo Yufan Wu Yi Hu Peiyi Liang Zeying Zheng Tao Liang Dan Zhai Yaling Guo Li Liu Chunyan Shen Cuiping Jiang Qun Shen Yankui Yi Qiang Liu 
Acne vulgaris ranks as the second most prevalent dermatological condition worldwide,and there are still insufficient safe and reliable drugs to treat it.Cryptotanshinone(CTS),a bioactive compound derived from traditio...
关键词：Carrier-free CRYPTOTANSHINONE Self-assembly ACNE 
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats
《Asian Pacific Journal of Tropical Biomedicine》2023年第7期296-305,共10页Khadga Raj Aran G.D.Gupta Shamsher Singh 
funded by the Indian Council of Medical Research with Grant Number 2020-8817,New Delhi,India。
Objective:To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats.Methods:Rats were administered with cladribine(1 mg/kg,p.o.)and cryptotanshinone(10 and 20 m...
关键词：Alzheimer's disease CLADRIBINE CRYPTOTANSHINONE NEUROTRANSMITTERS NEUROPROTECTIVE Proinflammatory cytokines Cognitive deficit 
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress被引量：2
《World Journal of Gastroenterology》2023年第17期2616-2627,共12页Xiao-Xue Hou Yu-Wen Li Jia-Li Song Wen Zhang Rui Liu Hui Yuan Tian-Tong Feng Zheng-Yi Jiang Wen-Ting Li Chuan-Long Zhu 
Science and Technology Plan of Hainan Province(Clinical Research Center),No.LCYX202103 and No.LCYX202204;Hainan Province Science and Technology Special Fund,No.ZDYF2022SHFZ067;Hainan Province Clinical Medical Center.
BACKGROUND Cryptotanshinone(CPT)has wide biological functions,including anti-oxidative,antifibrosis,and anti-inflammatory properties.However,the effect of CPT on hepatic fibrosis is unknown.AIM To investigate the effe...
关键词：Hepatic fibrosis Endoplasmic reticulum stress CRYPTOTANSHINONE Hepatic stellate cells APOPTOSIS 
Cryptotanshinone increases the sensitivity of liver cancer to sorafenib by inhibiting the STAT3/Snail/ epithelial mesenchymal transition pathway
《Frigid Zone Medicine》2022年第2期119-128,共10页Zhiyu Li Kegong Chen Chao Cui Yinghui Wang Dequan Wu 
Objective:Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer.The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver ...
关键词：CRYPTOTANSHINONE SORAFENIB sorafenib-resistance STAT3 signaling liver cancer 
Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions被引量：6
《World Journal of Gastrointestinal Oncology》2021年第7期693-705,共13页Zhang-Ming Chen Jie Hu Yuan-Min Xu Wei He Lei Meng Ting Huang Song-Cheng Ying Zhe Jiang A-Man Xu 
National Natural Science Foundation of China,No.81572350。
BACKGROUND Approximately 90%of new cases of noncardiac gastric cancer(GC)are related to Helicobacter pylori(H.pylori),and cytotoxin-associated gene A(CagA)is one of the main pathogenic factors.Recent studies have show...
关键词：Cytotoxin associated gene A SHP2 CRYPTOTANSHINONE Helicobacter pylori Chronic infection model 
Advance in Research on Anti-tumor Pharmacological Mechanism of Cryptotanshinone
《Medicinal Plant》2018年第6期11-14,共4页Jiaru WANG Lingqi MENG Yi ZHANG Hao WANG Wanting XU Yang LIU Yu ZHANG Tong ZHANG Shinong WANG Yuqing ZHAI Yinghua LUO Chenghao JIN 
Supported by Multigrain Production and Processing Characteristic Discipline Construction Project;Postdoctoral Scientific Research Foundation of Heilongjiang Province of China(LBH-Q13132)
Cryptotanshinone is a natural active ingredient extracted from traditional Chinese medicine Radix Salviae Miltiorrhizae.It has a variety of pharmacological effects,in addition to preventing and treating ischemic disea...
关键词：CRYPTOTANSHINONE ANTI-TUMOR CELL PROLIFERATION APOPTOSIS 
Apoptotic Effect of Cryptotanshinone on Human Melanoma A375 Cells
《Medicinal Plant》2018年第6期39-42,共4页Jinqian LI Jiaru WANG Lingqi MENG Yi ZHANG Hao WANG Wanting XU Yang LIU Yu ZHANG Shinong WANG Yuqing ZHAI Yinghua LUO Chenghao JIN 
Supported by Multigrain Production and Processing Characteristic Discipline Construction Project;Postdoctoral Scientific Research Foundation of Heilongjiang Province of China(LBH-Q13132)
[Objectives] The aim was to investigate the effect of cryptotanshinone on apoptosis of human melanoma A375 cells and its related mechanism of mitochondrial pathway.[Methods]The cytotoxic effect of cryptotanshinone on ...
关键词：CRYPTOTANSHINONE Human MELANOMA A375 cells CYTOTOXIC EFFECT Apoptosis AKT signaling pathway 
Cryptotanshinone suppresses key onco-proliferative and drugresistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation被引量：13
《Science China(Life Sciences)》2018年第9期999-1009,共11页Bowen Dong Zirui Liang Zhirong Chen Bin Li Lingling Zheng Jianhua Yang Hui Zhou Lianghu Qu 
supported by the National Natural Science Foundation of China (31471223, 31230042, 31771459, 31770879);the Project of Science and Technology of Guangzhou (201504010022);the National Key R&D Program of China (2017YFA0504400) from the Ministry of Science and Technology of China
C-Myc and signal transducer and activator of transcription(STAT) family proteins have been proposed to be important downstream genes of BCR-ABL, which characterizes most cases of chronic myeloid leukemia(CML). Here, w...
关键词：p-STAT3/5 microRNA CML MDR 
Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro
《Acta Pharmacologica Sinica》2018年第8期1393-1404,共12页Jin ZENG Yu-juan FAN Bo TAN Hui-zong SU Yue LI Lin-lin ZHANG Jian JIANG Fu-rong QIU 
This work was supported by the National Natural Science Foundation of China （No 81173118） and Shanghai Key Lab of Traditional Clinical Medicine （Grant C14dZ2273200）.
Cryptotanshinone （CT） is the main active component in the root of Salvia miltiorrhiza Bunge （SMB） that displays antibacterial, anti-inflammatory and anticancer activities. In this study, we characterized phase I a...
关键词：CRYPTOTANSHINONE P450 enzymes uridine diphosphate glucuronosyltransferases metabolic characteristics human liver microsomes 
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