MELANOMA

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Microneedle-Based Approaches for Skin Disease Treatment
《Nano-Micro Letters》2025年第6期143-180,共38页Yanhua Han Xiaoyu Qin Weisen Lin Chen Wang Xuanying Yin Jiaxin Wu Yang Chen Xiaojia Chen Tongkai Chen 
supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017);the National Natural Science Foundation of China(82104354);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154);the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...
关键词：MICRONEEDLES Androgenetic alopecia PSORIASIS Atopic dermatitis Hypertrophic scars MELANOMA 
Rare Differential Diagnosis of Hemorrhoidal Disease: Primary Anorectal Melanoma;a Case Report and Review of the Literature
《Case Reports in Clinical Medicine》2025年第2期58-63,共6页Willy Stéphane Kengne Joseph Idriss Djoko Gael Jacquemin Julie Vandepapeliere Lynn Gabrielle Alexis Silva De Vulder-Cotrina Adeline Donati Marie-Cécile Nollevaux Olivier Borgniet 
Anorectal melanoma is a rare tumor representing less than 1% of anorectal cancers and around 0.3% of malignant melanomas. Its prognosis is particularly poor due to the early occurrence of metastases. We report the cas...
关键词：Anorectal Melanoma Diagnosis Treatment PROGNOSIS Anatomopathology SURGERY 
The predictive value of NLR and SII in anti⁃MDA5 antibody⁃positive dermatomyositis with rapidly progressive interstitial lung disease
《南京医科大学学报(自然科学版)》2025年第2期196-207,共12页CAI Qingqing YOU Hanxiao WANG Lei LÜChengyin SHI Yumeng QIU Yulu WU Lingyun WANG Fang ZHANG Miaojia TAN Wenfeng 
国家自然科学基金(82171794,82071827,82271844);国家自然科学青年基金(82302041);国家重点研发计划课题(2021YFC2501305);江苏省科教能力提升项目(JSDW202203);宿迁市科技计划(KY202201,KY202302);江苏省医院临床能力提升项目(JSPH⁃MB⁃2023⁃13,JSPH⁃MA⁃2002⁃6)。
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(...
关键词：anti⁃melanoma differentiation⁃associated gene 5⁃positive dermatomyositis neutrophil⁃to⁃lymphocyte ratio rapidly pro⁃gressive interstitial lung disease systemic immune⁃inflammation index 
Immunomodulatory hydrogel neutralizes tumor acidity to augment immune responses for the prevention of post-surgical recurrence of melanoma
《Science China Materials》2025年第1期270-279,共10页Zhiyuan Quan Linghui Chen Beibei Chen Kangli Guo Pengfei Tian Haobo Pan Yang Li Nana Zhao Fu-Jian Xu 
National Key Research and Development Program of China (2021YFC2400500);National Natural Science Foundation of China (52173271, 52361165659, and 52221006);Beijing Outstanding Young Scientist Program(BJJWZYJH01201910010024)。
Post-resection recurrence remains a severe problem in melanoma treatment.New therapeutic strategies,such as chemodynamic therapy(CDT),exhibit high specificity and responsiveness,demonstrating potential to elicit antit...
关键词：borosilicate glasses tumor microenvironment chemodynamic therapy tumor acidity melanoma immunotherapy 
LPA suppresses HLA-DR expression in human melanoma cells:a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10
《Acta Pharmacologica Sinica》2025年第1期222-230,共9页Eniko Major Kuan-Hung Lin Sue Chin Lee Krisztina Kaldi Balazs Gyorffy Gabor J.Tigyi Zoltan Benyo 
This study was supported by NKFIH K-125174;K-132393;K-135683;K-139230;as well as by 2020-1.1.6-JOvO-2021-00010;TKP2021-EGA-25;EFOP-3.6.3-VEKOP-16-2017-00009 grants;by the Talentum Foundation by Gedeon Richter Plc,NCl grant CA092660;the Harriet Van Vleet Endowment;HUN-REN Hungarian Research Network;The authors thank Dr.Kyle Johnson-Moore from the UTHSC Office of Scientific Writing.Figure 6 and Supplementary Fig.S1 were created with BioRender.com;Open access funding provided by Semmelweis University.
While immune checkpoint inhibitors(ICis)are promising in the treatment of metastatic melanoma,about half of patients do not respond well to them.Low levels of human leukocyte antigen-DR(HLA-DR)in tumors have been show...
关键词：lysophosphatidic acid(LPA) MELANOMA death receptor 6(DR6) IL-10 LPAR1 HLA-DR 
Targeting IL-17A to manage immunotherapy-induced toxicity in melanoma
《Cancer Communications》2025年第1期56-57,共2页Kai Huang 
National Natural Science Foundation of China,Grant/Award Number:82103209;Taishan Schorlar of Shandong Province,Grant/Award Number:tsqn202103174。
The landscape of cancer treatment has been dramatically transformed by the advent of immune checkpoint inhibitors(ICIs),particularly in the management of advanced melanoma.However,despite their revolutionary success,t...
关键词：MELANOMA IMMUNOTHERAPY IMMUNE 
Targeting TMEM16A/ANO1 inhibits the progression of BRAF mutant(V600E)melanoma through the MEK/ERK and AKT signaling pathways
《Genes & Diseases》2024年第6期5-7,共3页Meiyun Shi Jiahui Wang Xingyu Huang Linsu Liu Lutao Liu Na Zhou Xinqi Shan Huaqun Chen 
The BRAF(V600E)mutation is common in malignant melanoma patients and drives constitutive activation of the MEK/ERK signaling pathway and cancer progression.1 To date,precision therapies targeting the BRAF/MEK/ERK path...
关键词：MEK/ERK V600E BRAF 
An immunotherapeutic hydrogel booster inhibits tumor recurrence and promotes wound healing for postoperative management of melanoma
《Bioactive Materials》2024年第12期178-193,共16页Yuanyuan Yang Bo Zhang Yangtao Xu Wenxiang Zhu Zinian Zhu Xibo Zhang Wenze Wu Jierong Chen Zhiqiang Yu 
supported by the National Natural Science Foundation of China(82372115 and 52073139);the China Postdoctoral Science Foundation(2023M731571);Dongguan Science and Technology of Social Development Program(20231800900322 and 20231800900362);the Postdoctoral Research Project Start-Up Funding of Dongguan People’s Hospital(319341);the Guangdong Basic and Applied Basic Research Foundation(2023B1515120084 and 2023A1515110016);the Training Program of National Natural Science Foundation of Dongguan People’s Hospital(Z202402).
Low tumor immunogenicity,immunosuppressive tumor microenvironment,and bacterial infections have emerged as significant challenges in postsurgical immunotherapy and skin regeneration for preventing melanoma recurrence....
关键词：Glutamine metabolism IMMUNOTHERAPY HYDROGEL MELANOMA Wound healing 
A retrospective observational study of patients with melanoma prescribed combined BRAF and MEK inhibitors in a real-world treatment setting in Japan
《Malignancy Spectrum》2024年第4期312-322,共11页Kenjiro Namikawa Kok Yew Ngew Zuzanna Lukowicz Ryosuke Kano 
funded by Novartis Japan,which developed and marketed TKIs for the treatment of melanoma.
Objective:This study aimed to describe patients with melanoma initiating treatments with dabrafenib plus trametinib(Dab+Tram)or encorafenib plus binimetinib(Enco+Bini)in a real-world setting in Japan.Methods:Data were...
关键词：BRAF medication use MEK MELANOMA targeted kinase inhibitor 
Primary malignant melanoma of the breast:A case report without relapse
《Malignancy Spectrum》2024年第4期339-345,共7页Alejandro Caballero Mario Perez Issis Rodriguez 
Objective:This study aimed to report the treatment and outcomes of a patient with primary malignant melanoma of the breast parenchyma using mastectomy as the main treatment.Patient and methods:A 67-year-old female pre...
关键词：MELANOMA BREAST MALIGNANCY MASTECTOMY 
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