MICRONEEDLES

作品数：81被引量：205H指数：9
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相关领域：医药卫生更多>>
相关机构：安徽医科大学更多>>
相关期刊：《BMEMat(BioMedical Engineering Materials)》《Frontiers of Materials Science》《Advances in Chemical Engineering and Science》《Microsystems & Nanoengineering》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划中国博士后科学基金泰国研究基金更多>>
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Microneedle-Based Approaches for Skin Disease Treatment
《Nano-Micro Letters》2025年第6期143-180,共38页Yanhua Han Xiaoyu Qin Weisen Lin Chen Wang Xuanying Yin Jiaxin Wu Yang Chen Xiaojia Chen Tongkai Chen 
supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017);the National Natural Science Foundation of China(82104354);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154);the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...
关键词：MICRONEEDLES Androgenetic alopecia PSORIASIS Atopic dermatitis Hypertrophic scars MELANOMA 
Microneedles for non-transdermal drug delivery:design strategies and current applications
《Bio-Design and Manufacturing》2025年第2期243-274,I0003,共33页Jinhong Xu Xiangyi Liao Danli Chen Xiuzhuo Jia Xufeng Niu 
financial support from the Beijing Natural Science Foundation(No.L234020);the National Natural Science Foundation of China(Nos.12472325 and 12272032);the 111 Project(No.B13003).
Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and biocompatibility.MNs wer...
关键词：Microneedles(MNs) Biocompatible materials Non-transdermal drug delivery Controlled release 
Traditional Chinese Medicine Integrated Multifunctional Responsive Core-Shell Microneedles for Dermatosis Treatment
《Research》2025年第1期569-577,共9页Xi Luan Xiaoxuan Zhang Qichen Luan Jingjing Gan Yu Wang Yuanjin Zhao 
supported by National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(T2225003);National Natural Science Foundation of China(52073060);National Natural Science Foundation of China(61927805);Nanjing Medical Science and Technique Development Foundation(ZKX21019);Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Natural Science Foundation of Jiangsu Province(BK20180408);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);Shenzhen Science and Technology Program(JCYJ20210324133214038).
Microneedles have demonstrated value in targeted treatment of dermatosis.Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects.Here,we present innovative sh...
关键词：SCLERODERMA light ph dual responsiveness treat sclerodermaby chinese herb drugs spatiotemporal sequential release 
Micro-vibration assisted dual-layer spiral microneedles to rapidly extract dermal interstitial fluid for minimally invasive detection of glucose
《Microsystems & Nanoengineering》2025年第1期155-172,共18页Khaled Mohammed Saifullah Asim Mushtaq Pouria Azarikhah Philip DPrewett Graham JDavies Zahra Faraji Rad 
Various hydrogels have been explored to create minimally invasive microneedles(MNs)to extract interstitial fluid(ISF).However,current methods are time-consuming and typically require 10–15 min to extract 3–5 mg of I...
关键词：gelatin methacryloyl gelma minimally invasive microneedles mns hyaluronic acid ha mn arrays micro vibration polyvinyl alcohol pva dual layer spiral microneedles extract interstitial fluid isf howevercurrent 
State-of-the-art Review of Metallic Microneedles:Structure,Fabrication,and Application
《Chinese Journal of Mechanical Engineering》2025年第1期84-105,共22页Zhishan Yuan Hongzhao Zhang Wentao Hu Xiao Yu Si Qin Chengyong Wang Fenglin Zhang 
Supported by Guangdong Provincial Key-Area Research and Development Program(Grant No.2023B0101200014);Guangdong Provincial Natural Science Foundation(Grant No.2024A1515010440).
Microneedle(MN)is a medical device containing an array of needles with a micrometer-scale.It can penetrate the human stratum corneum painlessly and efficiently for treatment and diagnosis purposes.Currently,the materi...
关键词：METAL MICRONEEDLES STRUCTURE FABRICATION Application 
Transdermal delivery of natural products against atopic dermatitis被引量：1
《Chinese Journal of Natural Medicines》2024年第12期1076-1088,共13页LI Minghui XU Yihua YU Yanan LI Wanshu CHEN Lixia ZHAO Bo GAO Yuli GAO Jianqing LIN Hangjuan 
supported by the NINGBO Medical & Health Leading Academic Discipline Project (No. 2022-ZF02);Ningbo Major Research and Development Plan Project (No.2023Z207)。
Atopic dermatitis(AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their ...
关键词：Transdermal drug delivery system Natural products HYDROGELS MICRONEEDLES Atopic dermatitis Stratum corneum 
Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
《Nano-Micro Letters》2024年第12期233-284,共52页Qingdong Bao Xiaoting Zhang Zhankun Hao Qinghua Li Fan Wu Kaiyuan Wang Yang Li Wenlong Li Hua Gao 
supported by the National Natural Science Foundation of China(82371032,82070923);the Major Basic Research Project of the Natural Science Foundation of Shandong Province(ZR2023ZD60);the Taishan Scholar Program(20231255);the Academic Promotion Program of Shandong First Medical University(2019RC009).
The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional...
关键词：Ocular delivery POLYSACCHARIDE MICRONEEDLES Drug administration 
Microneedles as transdermal drug delivery system for enhancing skin disease treatment被引量：1
《Acta Pharmaceutica Sinica B》2024年第12期5161-5180,共20页Chaoxiong Wu Qingyu Yu Chenlu Huang Fangzhou Li Linhua Zhang Dunwan Zhu 
supported by the National Natural Science Foundation of China(82172090,82302390 and 82072059);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-058 and 2022-I2M-1-023);China Postdoctoral Science Foundation(2022M720502);Natural Science Foundation of Tianjin Municipality(22JCQNJC00070);CAMS Union Young Scholars Support Program(2022051);Fundamental Research Funds for the Central Universities(2019PT320028).
Microneedles(MNs)serve as a revolutionary paradigm in transdermal drug delivery,herald-ing a viable resolution to the formidable barriers presented by the cutaneous interface.This review examines MNs as an advanced ap...
关键词：MICRONEEDLES Skin diseases Superficial tumor PSORIASIS Atopic dermatitis Diabetic wound Infected wound Aesthetic skin issues 
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing
《Acta Pharmaceutica Sinica B》2024年第11期5037-5052,共16页Yongnian Zeng Chenyuan Wang Jiapeng Lei Xue Jiang Kai Lei Yinli Jin Tianshu Hao Wen Zhang Jianying Huang Wei Li 
National Natural Science Foundation of China(NSFC,Nos.82373798,52103182);the Special Project for Significant New Drug Research and Development in the Major National Science and Technology Projects of China(project No.2020ZX09201007);Innovation Transformation Research Project of Zhongnan Hospital of Wuhan University(project No.YXCXZH2024003,China).
High glucose level, bacterial infection, and persistent inflammation within the microenvironment are key factors contributing to the delay of diabetic ulcers healing, while traditional therapeutic methods generally fa...
关键词：MICRONEEDLE Wound healing DRUGDELIVERY Sustained release Nitric oxide Glucosedepletion Glucose oxidase Nanoparticles 
Construction and investigation of all-inone microneedles complexed with functionalized polydiacetylene liposomes for improved in situ detection sensitivity
《hLife》2024年第10期514-526,共13页Jiarui Wang Weimiao Li Yan Chen Meng Wu Yan Shi Jumin Lee Ming Kong 
funded by the Natural Science Foundation of Shandong Province(ZR2022MC033);the Qingdao Science&Technology Benefiting People Project(24-1-8-smjk-11-nsh).
Polydiacetylene(PDA)liposomes have been widely applied for detection due to their distinctive optical properties.How-ever,the liquid phase in which PDA liposomes are dispersed generates several drawbacks,for instance,...
关键词：polydiacetylene liposomes complexed swellable microneedles ALL-IN-ONE improved detection sensitivity 
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