Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases  

作　　者：Qingdong Bao Xiaoting Zhang Zhankun Hao Qinghua Li Fan Wu Kaiyuan Wang Yang Li Wenlong Li Hua Gao 

机构地区：[1]State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Eye Institute of Shandong First Medical University,Qingdao 266071,People’s Republic of China [2]State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,People’s Republic of China [3]Eye Hospital of Shandong First Medical University,Jinan 250021,People’s Republic of China [4]College of Ophthalmology,Shandong First Medical University,Jinan 250000,People’s Republic of China [5]Departments of Diagnostic Radiology,Surgery,Chemical and Biomolecular Engineering,and Biomedical Engineering,Yong Loo Lin School of Medicine and College of Design and Engineering,National University of Singapore,Singapore 119074,Singapore

出　　处：《Nano-Micro Letters》2024年第12期233-284,共52页纳微快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82371032,82070923);the Major Basic Research Project of the Natural Science Foundation of Shandong Province(ZR2023ZD60);the Taishan Scholar Program(20231255);the Academic Promotion Program of Shandong First Medical University(2019RC009).

摘　　要：The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance.Polysaccharidebased microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug delivery.However,a comprehensive review of PSMNs in ophthalmology has not been published to date.In this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery.We provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and compliance.We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios.Finally,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

关 键 词：Ocular delivery POLYSACCHARIDE MICRONEEDLES Drug administration 

分 类 号：R77[医药卫生—眼科]