Traditional Chinese Medicine Integrated Multifunctional Responsive Core-Shell Microneedles for Dermatosis Treatment  

作　　者：Xi Luan Xiaoxuan Zhang Qichen Luan Jingjing Gan Yu Wang Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Pharmacy,Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [3]Shenzhen Research Institute,Southeast University,Shenzhen 518071,China

出　　处：《Research》2025年第1期569-577,共9页研究(英文)

基　　金：supported by National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(T2225003);National Natural Science Foundation of China(52073060);National Natural Science Foundation of China(61927805);Nanjing Medical Science and Technique Development Foundation(ZKX21019);Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Natural Science Foundation of Jiangsu Province(BK20180408);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);Shenzhen Science and Technology Program(JCYJ20210324133214038).

摘　　要：Microneedles have demonstrated value in targeted treatment of dermatosis.Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects.Here,we present innovative shell-core microneedles with light-pH dual responsiveness for spatiotemporal sequential release of multiple Chinese herb drugs to treat scleroderma.By using a stepwise template-assisted method,we effectively prepare a hydrogel-based core layer containing polydopamine-MXene(P-MXene)loaded with triptolide(TP),and a shell layer composed of polyvinyl alcohol(PVA)encapsulating paeoniflorin(Pae).P-MXene can adsorb the sparingly soluble TP to ensure its encapsulation efficiency and contribute to the synergistic photothermal effect benefitting from its excellent photothermal conversion ability.Besides,PVA can rapidly dissolve upon microneedle piercing into the skin and quickly release the anti-inflammatory and detoxifying Pae,establishing a favorable low-acid subcutaneous environment.In response to pH changes and near-infrared effects,TP is sustainably released from P-MXene and delivered through the swollen pores of the hydrogel.On the basis of these characteristics,we demonstrate that these microneedles could effectively reduce profibrotic key cytokines interleukin-1βand transforming growth factor-β,thereby reducing collagen deposition and decreasing epidermal thickness,ameliorating skin fibrosis and capillary lesion in scleroderma mouse models.These findings highlight the important clinical potential of these microneedles in the treatment of skin diseases.

关 键 词：SCLERODERMA light ph dual responsiveness treat sclerodermaby chinese herb drugs spatiotemporal sequential release 

分 类 号：R285[医药卫生—中药学]